US4957481A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Photodynamic therapeutic technique
Assignee: MedImmune LLC
•
Filing: 1989-07-03
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Granted: 1990-09-18
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Expires: 2009-07-03
Abstract
Abstract The present invention is directed toward methods for the reduction of the severity of symptoms resulting from tumors, such as pain induced by the pressure exerted on a nerve by the tumor mass. Additionally, methods for the reduction of tumor size are also contemplated.
Inventors
- 👤 Robert A. Gatenby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:47
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/06; A61N5/0613; A61N5/062; A61N5/0601
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
106 words
A method of reducing the severity of symptoms resulting from the presence of a tumor in a subject comprising: (1) injection of an effective amount of a photosensitive compound directly into said tumor in at least one location in said tumor; (2) insertion of at least one sheathed light source, completely sheathed in a clear sheath catheter, into said tumor, said light source being capable of emitting light at a wavelength which is absorbed by said photosensitive compound; and (3) activation of said light source whereby said light is absorbed by said photosensitive compound, thereby disrupting the tumor cells and reducing the severity of tumor-induced symptoms.
Claim 2
Independent Claim
106 words
A method of reducing the severity of symptoms resulting from the presence of a tumor in a subject comprising: (1) injection of an effective amount of a photosensitive compound directly into said tumor in at least one location in said tumor; (2) insertion of at least one sheathed light source, completely sheathed in a clear sheath catheter, into said tumor, said light source being capable of emitting light at a wavelength which is absorbed by said photosensitive compound; and (3) activation of said light source whereby said light is absorbed by said photosensitive compound, thereby disrupting the tumor cells and reducing the severity of tumor-induced symptoms.
Claim 3
Dependent Claim
14 words
A method of claim 1, wherein said insertion includes inserting a fiberoptic light source.
Claim 4
Dependent Claim
12 words
A method of claim 2, wherein said insertion includes inserting a laser.
Claim 5
Dependent Claim
24 words
A method of claim 1, wherein said light source emits at a wavelength corresponding to a wavelength of peak absorption of said photosensitive compound.
Claim 6
Dependent Claim
24 words
A method of claim 1, wherein said photosensitive compound is administered in an amount between about 5 and about 200 micrograms/g of tumor tissue.
Claim 7
Dependent Claim
24 words
A method of claim 1, wherein said photosensitive compound is administered in an amount between about 80 and about 120 micrograms/g of tumor tissue.
Claim 8
Dependent Claim
14 words
A method of claim 1, wherein said catheter is made of a fluorinated polymer.
Claim 9
Dependent Claim
13 words
A method of claim 1, wherein said photosensitive compound is hematoporphyrin derivative HpD.
Claim 10
Dependent Claim
16 words
A method of claim 8, wherein said light source emits a wavelength of about 630 nm.
Claim 11
Dependent Claim
13 words
A method of claim 1, wherein said tumor is a large, deep tumor.
Claim 12
Dependent Claim
14 words
A method of claim 1, wherein said injection is accomplished under computed tomographic guidance.
Claim 13
Dependent Claim
14 words
A method of claim 1, wherein said insertion is accomplished under computed tomographic guidance.
Claim 14
Dependent Claim
14 words
A method of claim 1, wherein said activation is accomplished under computed tomographic guidance.
Claim 15
Independent Claim
90 words
A method of reducing the size of a tumor present in a subject comprising: (1) injection of an effective amount of a photosensitive compound directly into said tumor in at least one location in said tumor; (2) insertion of at least one sheathed light source into said tumor capable of emitting light at a wavelength which is absorbed by said photosensitive compound; and (3) activation of said light source whereby said light is absorbed by said photosensitive compound thereby disrupting the tumor cells and reducing the size of said tumor.
Claim 16
Independent Claim
90 words
A method of reducing the size of a tumor present in a subject comprising: (1) injection of an effective amount of a photosensitive compound directly into said tumor in at least one location in said tumor; (2) insertion of at least one sheathed light source into said tumor capable of emitting light at a wavelength which is absorbed by said photosensitive compound; and (3) activation of said light source whereby said light is absorbed by said photosensitive compound thereby disrupting the tumor cells and reducing the size of said tumor.
Claim 17
Dependent Claim
14 words
A method of claim 14, wherein said insertion includes inserting a fiberoptic light source.
Claim 18
Dependent Claim
12 words
A method of claim 15, wherein said insertion includes inserting a laser.
Claim 19
Dependent Claim
24 words
A method of claim 14, wherein said light source emits at a wavelength corresponding to a wavelength of peak absorption of said photosensitive compound.
Claim 20
Dependent Claim
24 words
A method of claim 14, wherein said photosensitive compound is administered in an amount between about 5 and about 200 micrograms/g of tumor tissue.
Claim 21
Dependent Claim
24 words
A method of claim 14, wherein said photosensitive compound is administered in an amount between about 80 and about 120 micrograms/g of tumor tissue.
Claim 22
Dependent Claim
19 words
A method of claim 14, wherein said insertion includes inserting a light source sheathed in a clear, sheath catheter.
Claim 23
Dependent Claim
14 words
A method of claim 20, wherein said catheter is made of a fluorinated polymer.
Claim 24
Dependent Claim
13 words
A method of claim 14, wherein said photosensitive compound is hematoporphyrin derivative HpD.
Claim 25
Dependent Claim
16 words
A method of claim 22, wherein said light source emits a wavelength of about 630 nm.
Claim 26
Dependent Claim
13 words
A method of claim 14, wherein said tumor is a large, deep tumor.
Claim 27
Dependent Claim
17 words
A method of claim 14, wherein said injection and said insertion is accomplished under computed tomographic guidance.
Claim 28
Dependent Claim
14 words
A method of claim 14, wherein said insertion is accomplished under computed tomographic guidance.
Claim 29
Dependent Claim
14 words
A method of claim 14, wherein said activation is accomplished under computed tomographic guidance.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-09-17 | 1994-03-19 | 1994-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-17 | 1998-03-19 | 1998-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-17 | 2002-03-19 | 2002-09-18 | $7700.00 | Window Closed / Lapsed |