US4577636A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for diagnosis of atherosclerosis
Assignee: Beth Israel Deaconess Medical Center
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Filing: 1984-01-27
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Granted: 1986-03-25
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Expires: 2004-01-27
Abstract
Abstract Method for diagnosis of the presence of atherosclerosis plaques. The method comprises injection of a hematoporphyrin which is selectively absorbed by atheromotous plaques. The hematoporphyrin is then subjected to light causing it to fluorese and the fluorescence is used to diagnose the presence of the plaques.
Inventors
- 👤 J. Richard Spears
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:32
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61B; A61B17/00; A61B17/22; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; A61B18/245; A61M; A61M29/00; A61M29/02; A61B2017/00681; A61B2017/00694; A61B2017/22038; A61B2017/22051; A61B2017/22057; A61B2017/22059; A61B2017/22082; A61B2017/22085; A61B2017/22087; A61B2018/2255; A61B2018/2261; A61B90/00; A61B90/30; A61B2090/306
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
53 words
A method for diagnosing atherosclerosis, said method comprising: injecting a porphyrin solution into the blood vessels to be examined; detecting the quantity of porphyrins absorbed by tissues in the blood vessels; and contrasting the quantity of porphyrins in different areas of the blood vessels to determine location, size, and quantity of athermatous plaques.
Claim 2
Independent Claim
53 words
A method for diagnosing atherosclerosis, said method comprising: injecting a porphyrin solution into the blood vessels to be examined; detecting the quantity of porphyrins absorbed by tissues in the blood vessels; and contrasting the quantity of porphyrins in different areas of the blood vessels to determine location, size, and quantity of athermatous plaques.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein the porphyrins are radiolabeled.
Claim 4
Dependent Claim
14 words
The method of claim 1 wherein a radio-opaque material is bound to the porphyrins.
Claim 5
Dependent Claim
13 words
The method of claim 1 wherein a metal is bound to the porphyrin.
Claim 6
Dependent Claim
27 words
The method of claim 1 wherein the preferential absorbtion of porphyrins by atheromatous plaques is detected by illuminating the plaques with ultraviolet light and detecting the fluorescence.
Claim 7
Dependent Claim
21 words
The method of claim 4 wherein the preferential absorbtion of porphyrins by atheromatous plaques is detected by nuclear magnetic resonance spectroscopy.
Claim 8
Dependent Claim
20 words
The method of claim 2 wherein the preferential absorbtion of porphyrins by atheromatous plaques is detected by radionuclide scintillation techniques.
Claim 9
Dependent Claim
15 words
The method of claim 3 wherein the preferential absorbtion of X-rays by porphyrins is detected.
Claim 10
Dependent Claim
17 words
The method of claim 2 wherein the preferential absorbtion of porphyrins is detected by Positron Emission Tomography.
Claim 11
Dependent Claim
21 words
The method of claim 1 wherein an antibody specific for a component of the atheromatous plaques is bound to the porphyrins.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-24 | 1989-09-23 | 1990-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-24 | 1993-09-23 | 1994-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-24 | 1997-09-23 | 1998-03-25 | $7700.00 | Window Closed / Lapsed |