Patent US4946435A successfully refreshed from Google Patents.
US4946435A
Expired / Lapsed
US
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Flexible sealed radioactive film for radiotherapy, and method of making same
Assignee: Cordis Corp
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Filing: 1988-10-24
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Granted: 1990-08-07
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Expires: 2008-10-24
Abstract
Abstract A flexible sealed radioactive film for medical treatments comprising a radioactive material on or in a flexible substantially two-dimensional film and sealed in a substantially two-dimensional envelope. A number of flexible sealed radioactive film units can be provided in the form of a perforated strip wherein any number of flexible sealed film units can be easily removed from the perforated strip and applied to the site of treatment. The flexible sealed radioactive film can be easily applied to irregular contours to provide radiation treatment for diseased tissue and the like. Methods of making the flexible sealed radioactive film are also disclosed.
Inventors
- 👤 Krishnan Suthanthiran
- 👤 Raj Lakshman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:38
CPC Classifications
G; G03; G03C; G03C3/00; G03C3/003; A; A61; A61K; A61K51/00; A61K51/12; A61K51/1279; A61K9/00; A61K9/70; A61K2121/00
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
44 words
A flexible sealed radioactive film for medical treatments including implantation within a living body, comprising: a substantially flat, flexible carrier film; a radioactive material in or on said flexible carrier film; and a substantially flat, flexible envelope having the flexible carrier film sealed therein.
Claim 2
Dependent Claim
44 words
A flexible sealed radioactive film for medical treatments including implantation within a living body, comprising: a substantially flat, flexible carrier film; a radioactive material in or on said flexible carrier film; and a substantially flat, flexible envelope having the flexible carrier film sealed therein.
Claim 3
Dependent Claim
28 words
The flexible sealed radioactive film of claim 1, wherein, said carrier film comprises a material selected from the group consisting of polyvinyl chloride, polytetrafluoroethylene, cellulose esters and polysulfones.
Claim 4
Dependent Claim
16 words
The flexible sealed radioactive film of claim 1, wherein said carrier film is a membrane filter.
Claim 5
Dependent Claim
24 words
The flexible sealed radioactive film of claim 3, wherein said membrane- filter has a pore size sufficiently small to trap said radioactive material thereon.
Claim 6
Dependent Claim
21 words
The flexible sealed radioactive film of claim 4, wherein said pore size ranges from about 0.1 microns to about 1.0 microns.
Claim 7
Dependent Claim
16 words
The flexible sealed radioactive film of claim 5, wherein said pore size is about 0.45 microns.
Claim 8
Dependent Claim
21 words
The flexible sealed radioactive film of claim 1, wherein said carrier film is from about 20 to about 1000 microns thick.
Claim 9
Dependent Claim
17 words
The flexible sealed radioactive film of claim 7, wherein said carrier film is about 125 microns thick.
Claim 10
Dependent Claim
25 words
The flexible sealed radioactive film of claim 1, wherein said carrier film has dimensions ranging from about 2 mm×2 mm to about 100 mm×100 mm.
Claim 11
Dependent Claim
17 words
The flexible sealed radioactive film of claim 1, wherein said carrier film contains a radioactive absorbing material.
Claim 12
Dependent Claim
58 words
The flexible sealed radioactive film of claim 10, wherein said radioactive absorbing material is selected from the group consisting of activated carbon, charcoal, sulfonated polystyrene resins, methylene-sulfonic phenolic resins, phosphoric polystyrene resins, polystyrene resins containing quaternary ammonium groups, pyridinium polystyrene resins, epoxy-polyamine resins containing tertiary and quaternary ammonium groups, iminodiacetic polystyrene resins, and polystyrene resins containing polyamine groups.
Claim 13
Dependent Claim
17 words
The flexible sealed radioactive film of claim 1, wherein said radioactive material is a radio-labeled polyamino acid.
Claim 14
Dependent Claim
17 words
The flexible sealed radioactive film of claim 12, wherein said radio-labeled polyamino acid is radio-labeled polytyrosine .
Claim 15
Dependent Claim
20 words
The flexible sealed radioactive film of claim 12, wherein said polyamino acid is labeled with 125 I or 14 C.
Claim 16
Dependent Claim
14 words
The flexible sealed radioactive film of claim 13, wherein said radio-labeled polytyrosine is poly-D-tyrosine.
Claim 17
Dependent Claim
16 words
The flexible sealed radioactive film of claim 1, wherein said radioactive material is a radio-labeled polynucleotide.
Claim 18
Dependent Claim
16 words
The flexible sealed radioactive film of claim 16, wherein said polynucleotide is labeled with 32 P.
Claim 19
Dependent Claim
33 words
The flexible sealed radioactive film of claim 1, wherein said radioactive material is a molecule having a molecular weight greater than 10,000 and having a varying number of binding sites for radioactive substituents.
Claim 20
Dependent Claim
67 words
The flexible sealed radioactive film of claim 1, wherein said radioactive material is selected from the group consisting of 125 I, 103 Pd, 131 Cs, 134 Cs, 137 Cs, 111 Ag, 235 U, 198 Au, 32 P and 14 C, and isotopes of rubidium, calcium, barium, scandium, titanium, chromium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, indium, cadmium, the rare earths, mercury, lead, americium and neptunium.
Claim 21
Dependent Claim
15 words
The flexible sealed radioactive film of claim 1, wherein said radioactive material is 125 I.
Claim 22
Dependent Claim
15 words
The flexible sealed radioactive film of claim 1, wherein said radioactive material is 32 P.
Claim 23
Dependent Claim
28 words
The flexible sealed radioactive film of claim 1, wherein said envelope is made of a material selected from the group consisting of polytetrafluoroethylene, polyethylene, cellulose esters and polysulfones.
Claim 24
Dependent Claim
26 words
The flexible sealed radioactive film of claim 1 wherein said envelope has a wall thickness in the range of about 50 microns to about 1000 microns.
Claim 25
Dependent Claim
20 words
The flexible sealed radioactive film of claim 1, further comprising a sealed edge around the outer periphery of said envelope.
Claim 26
Dependent Claim
14 words
The flexible sealed radioactive film of claim 24, wherein said edge includes suture holes.
Claim 27
Dependent Claim
22 words
The flexible sealed radioactive film of claim 1, wherein an adhesive layer is provided on at least one side of said envelope.
Claim 28
Dependent Claim
18 words
The flexible sealed radioactive film of claim 26, further comprising a protective, peelable covering for said adhesive layer.
Claim 29
Dependent Claim
25 words
The flexible sealed radioactive film of claim 1, wherein two or more sealed films are integrally held together at edges thereof to form a strip.
Claim 30
Dependent Claim
18 words
The flexible sealed radioactive film of claim 28, wherein said strip includes perforations between each corresponding sealed film.
Claim 31
Dependent Claim
21 words
The flexible sealed radioactive film of claim 1, wherein one side of said envelope is provided with a radiation shielding material.
Claim 32
Dependent Claim
33 words
The flexible sealed radioactive film of claim 30, wherein said radiation shielding material is selected from the group consisting of tin, silver, lead, gold, tungsten, platinum, stainless steel, brass, copper and alloys thereof.
Claim 33
Dependent Claim
15 words
The flexible sealed radioactive film of claim 30, wherein said shielding material is tin foil.
Claim 34
Dependent Claim
23 words
The flexible sealed radioactive film of claim 1, wherein said flexible carrier film is coated with a sealing material to form said envelope.
Claim 35
Dependent Claim
14 words
The flexible sealed radioactive film of claim 33, wherein said sealing material is cyanoacrylate.
Claim 36
Dependent Claim
24 words
The flexible sealed radioactive film of claim 1, further comprising a second substantial two-dimensional flexible envelope having the flexible sealed radioactive film sealed therein.
Claim 37
Dependent Claim
13 words
The flexible sealed radioactive film of claim 1, wherein said envelope comprises tape.
Claim 38
Dependent Claim
15 words
The flexible sealed radioactive film of claim 1, further comprising marking indicia on said envelope.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-06 | 1994-02-05 | 1994-08-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-06 | 1998-02-05 | 1998-08-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-06 | 2002-02-05 | 2002-08-07 | $7700.00 | Window Closed / Lapsed |