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US4930516A
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Method for detecting cancerous tissue using visible native luminescence
Assignee: Laser Diagnostic Instruments AS
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Filing: 1988-04-25
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Granted: 1990-06-05
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Expires: 2008-04-25
Abstract
Abstract A method and apparatus for detecting the presence of cancerous tissue using visible luminescence. The tissue to be examined is excited with a beam of monochromatic light that causes the tissue to fluoresce over a spectrum of wavelengths. The intensity at which the excited tissue fluoresces can be measured either over a spectrum or at a predetermined number of preselected wavelengths. By determining the wavelength(s) at which maximum intensity(ies) are attained for the tissue in question and by comparing these peak wavelengths, either visually or electronically, to the peak wavelength(s) derived from a known non-cancerous tissue, or by comparing the spectrum of the excited tissue with the spectrum of a known noncancerous tissue one can determine the carcinomatoid status of the tissue in question. The invention is based on the discovery that the visible luminescence spectra for cancerous and non-cancerous tissue are substantially different and that the differences are such that visible luminescence from tissue can be used to detect the presence of cancer.
Inventors
- 👤 Robert R. Alfano
- 👤 Michele A. Alfano
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:46
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/0059; Y; Y10; Y10S; Y10S607/00; Y10S607/901
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
44 words
A method for determining if tissue is cancerous comprising: a. exciting a tissue to be examined with a beam of light, and b. comparing the visible native luminescence emitted from the tissue with the visible native luminescence emitted from tissue whose condition is known.
Claim 2
Independent Claim
44 words
A method for determining if tissue is cancerous comprising: a. exciting a tissue to be examined with a beam of light, and b. comparing the visible native luminescence emitted from the tissue with the visible native luminescence emitted from tissue whose condition is known.
Claim 3
Independent Claim
48 words
A method for determining if tissue is cancerous comprising: a. exciting a tissue to be examined with a beam of light. b. observing the visible native luminescence emitted from the tissue at least two wavelengths, and c. determining if the tissue is cancerous in accordance with said measurements.
Claim 4
Independent Claim
48 words
A method for determining if tissue is cancerous comprising: a. exciting a tissue to be examined with a beam of light. b. observing the visible native luminescence emitted from the tissue at least two wavelengths, and c. determining if the tissue is cancerous in accordance with said measurements.
Claim 5
Independent Claim
43 words
A method for detecting cancerous tissue comprising: a. exciting a tissue to be examined with a beam of light that is substantially monochromatic, and then b. comparing the resulting native luminescence spectrum with the native luminescence spectra for native normal and cancerous tissue.
Claim 6
Independent Claim
43 words
A method for detecting cancerous tissue comprising: a. exciting a tissue to be examined with a beam of light that is substantially monochromatic, and then b. comparing the resulting native luminescence spectrum with the native luminescence spectra for native normal and cancerous tissue.
Claim 7
Independent Claim
55 words
A method for detecting cancerous tissue comprising: a. exciting a tissue to be examined with a beam of light that is at least substantially monochromatic. b. measuring the intensity of the visible native luminescence emitted from the tissue at least two wavelengths, and c. determining if the tissue is cancerous in accordance with said measurements.
Claim 8
Independent Claim
55 words
A method for detecting cancerous tissue comprising: a. exciting a tissue to be examined with a beam of light that is at least substantially monochromatic. b. measuring the intensity of the visible native luminescence emitted from the tissue at least two wavelengths, and c. determining if the tissue is cancerous in accordance with said measurements.
Claim 9
Dependent Claim
41 words
The method of claim 4 and wherein determining if cancerous tissue is present comprises determining the ratios in intensities at at least two wavelengths and then comparing the ratios with the ratios of intensities at the same wavelengths for normal tissue.
Claim 10
Dependent Claim
33 words
The method of claim 4 and wherein determining if cancerous tissue is present includes producing a signal corresponding to the ratio between the intensities at least two wavelengths and then displaying said signals.
Claim 11
Dependent Claim
29 words
The method of claim 4 and wherein determining if cancerous tissue is present comprises producing a signal corresponding to the difference in the intensity at at least two wavelengths.
Claim 12
Dependent Claim
24 words
The method of claim 4 and wherein determining if cancerous tissue is present comprises producing a signal corresponding to the difference in spectral profiles.
Claim 13
Independent Claim
47 words
A method for detecting cancerous tissue comprising: a. exciting a tissue to be examined with a beam of monochromatic light. b. generating a luminescence spectrum native of light emitted by the tissue, and c. comparing the luminescent spectrum with a luminescent spectrum for a known normal tissue.
Claim 14
Independent Claim
47 words
A method for detecting cancerous tissue comprising: a. exciting a tissue to be examined with a beam of monochromatic light. b. generating a luminescence spectrum native of light emitted by the tissue, and c. comparing the luminescent spectrum with a luminescent spectrum for a known normal tissue.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-04 | 1993-12-04 | 1994-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-04 | 1997-12-04 | 1998-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-04 | 2001-12-04 | 2002-06-05 | $7700.00 | Window Closed / Lapsed |