Patent US4928603A successfully refreshed from Google Patents.
US4928603A
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Method of preparing a cryoprecipitated suspension and use thereof
Assignee: Columbia University
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Filing: 1988-06-06
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Granted: 1990-05-29
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Expires: 2008-06-06
Abstract
Abstract This invention concerns a method of preparing a cryoprecipitated suspension containing fibrinogen and Factor XIII useful as a precursor in the preparation of a fibrin glue which involves (a) freezing fresh frozen plasma from a single donor such as a human or other animal, e.g., a cow, sheep or pig, which has been screened for blood transmitted diseases, e.g., one or more of syphilis, hepatitis or acquired immune deficiency syndrome at about -80° C. for at least 6 hours, preferably for at least about 12 hours; (b) raising the temperature, so as to form a supernatant and a cryoprecipitated suspension containing fibrinogen and Factor XIII; and (c) recovering the cryopricipitated suspension.
Inventors
- 👤 Eric Rose
- 👤 Arthur Dresdale
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:24
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; A61L24/001; A61L24/0015; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/418
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
82 words
A method of preparing a cryoprecipitated suspension containing fibrinogen and Factor XIII useful as a precursor in the preparation of a fibrin glue which consists essentially of: (a) freezing fresh frozen plasma from a single donor which has been screened for blood transmitted diseases at about -80° C. for at least 6 hours, (b) raising the temperature of the frozen plasma so as to form a supernatant and a cryoprecipitated suspension containing fibrinogen and Factor XIII, and (c) recovering the cryoprecipitated suspension.
Claim 2
Independent Claim
82 words
A method of preparing a cryoprecipitated suspension containing fibrinogen and Factor XIII useful as a precursor in the preparation of a fibrin glue which consists essentially of: (a) freezing fresh frozen plasma from a single donor which has been screened for blood transmitted diseases at about -80° C. for at least 6 hours, (b) raising the temperature of the frozen plasma so as to form a supernatant and a cryoprecipitated suspension containing fibrinogen and Factor XIII, and (c) recovering the cryoprecipitated suspension.
Claim 3
Dependent Claim
14 words
A method of claim 1, wherein the donor is a human or other animal.
Claim 4
Dependent Claim
15 words
A method of claim 2, wherein the donor is a cow, sheep or a pig.
Claim 5
Dependent Claim
22 words
A method of claim 1, wherein the blood transmitted diseases comprise one or more of syphilis, hepatitis or acquired immune deficiency syndrome.
Claim 6
Dependent Claim
21 words
A method of claim 1, wherein the fresh frozen plasma is frozen in step (a) for at least about 12 hours.
Claim 7
Dependent Claim
26 words
A method of claim 1, wherein the temperature of the frozen plasma is raised in step (b) to between about 0° C. and about room temperature.
Claim 8
Dependent Claim
18 words
A method of claim 1, wherein recovering the cryoprecipitated suspension comprises decanting the supernatant from the cryoprecipitated suspension.
Claim 9
Dependent Claim
14 words
A method of claim 1 which further comprises concentrating the cryoprecipitated suspension by centrifugation.
References Cited (Backward Citations)
US2112496A
Cited
US4025618A
Cited
US4203891A
Cited
US4362567A
Cited
US4414976A
Cited
US4427650A
Cited
US4427651A
Cited
US4442655A
Cited
US4383989A
Cited
US4416812A
Cited
US4627879A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-28 | 1993-11-27 | 1994-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-28 | 1997-11-27 | 1998-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-28 | 2001-11-27 | 2002-05-29 | $7700.00 | Window Closed / Lapsed |