US4901725A — Minute volume rate-responsive pacemaker

Claim 1

Independent Claim 158 words

A rate-responsive pacemaker comprising means adapted to a patient'heart for pulsing at a controlled rate; a bipolar lead having tip and ring electrodes for coupling said pulsing means to the patient's heart, said pulsing means extending pacing current pulses to said tip electrode, said tip electrode being positionable on the heart wall and said ring electrode being positionable in a blood vessel in the vicinity of the patient's pleural cavity; means for periodically applying measuring current pulses between said ring electrode and a reference point in said pacemaker; means for measuring the blood impedance between said tip electrode and said reference point responsive to the application of a measuring current pulse between said ring electrode and said reference point, as the blood impedance varies as a function of the patient's pleural pressure; means responsive to said measuring means for determining the patient's minute volume; and means for changing said controlled rate in accordance with the patient's minute volume.

Claim 2

Dependent Claim 158 words

A rate-responsive pacemaker comprising means adapted to a patient'heart for pulsing at a controlled rate; a bipolar lead having tip and ring electrodes for coupling said pulsing means to the patient's heart, said pulsing means extending pacing current pulses to said tip electrode, said tip electrode being positionable on the heart wall and said ring electrode being positionable in a blood vessel in the vicinity of the patient's pleural cavity; means for periodically applying measuring current pulses between said ring electrode and a reference point in said pacemaker; means for measuring the blood impedance between said tip electrode and said reference point responsive to the application of a measuring current pulse between said ring electrode and said reference point, as the blood impedance varies as a function of the patient's pleural pressure; means responsive to said measuring means for determining the patient's minute volume; and means for changing said controlled rate in accordance with the patient's minute volume.

Claim 3

Dependent Claim 101 words

A rate-responsive pacemaker comprising means adapted to a patient's heart for pulsing at a controlled rate; a bipolar lead having tip and ring electrodes for coupling said pulsing means to the patient's heart; means for deriving a blood impedance signal by periodically introducing current pulses between said ring electrode and a reference point and measuring the voltage across said tip electrode and said reference point; said tip electrode being at a point in the patient's blood more distal from said reference point than said ring electrode; and means for adjusting said controlled rate as a function of said blood impedance signal.

Claim 4

Dependent Claim 101 words

A rate-responsive pacemaker comprising means adapted to a patient's heart for pulsing at a controlled rate; a bipolar lead having tip and ring electrodes for coupling said pulsing means to the patient's heart; means for deriving a blood impedance signal by periodically introducing current pulses between said ring electrode and a reference point and measuring the voltage across said tip electrode and said reference point; said tip electrode being at a point in the patient's blood more distal from said reference point than said ring electrode; and means for adjusting said controlled rate as a function of said blood impedance signal.

Claim 5

Dependent Claim 57 words

A rate-responsive pacemaker in accordance with claim 2 wherein said adjusting means includes means for deriving a short-term average and means for deriving a long-term average of said blood impedance signal, means for deriving a difference between said short-term average and said long-term average, and means for varying said controlled rate in accordance with the derived difference.

Claim 6

Dependent Claim 28 words

A rate-responsive pacemaker in accordance with claim 3 further including means for inhibiting the deriving of said long-term average responsive to said derived difference exceeding a threshold value.

Claim 7

Dependent Claim 59 words

A rate-responsive pacemaker in accordance with claim 3 wherein said means for deriving said averages includes means for generating samples representative of an average value of said impedance signal over a relatively short interval, means for detecting zero crossings in said impedance signal, and means for controlling average means to up-date an average when a zero crossing is detected.

Claim 8

Dependent Claim 42 words

A responsive pacemaker in accordance with claim 5, wherein a period over which values are averaged to generate said short-term average and a period over which values are averaged to generate said long-term average differ by at least an order of magnitude.

Claim 9

Dependent Claim 85 words

A rate-responsive pacemaker comprising pulse generating means for generating pulses at a rate; means for coupling said pulse generating means to a patient's heart; means for monitoring a rate control parameter ("RCP"); means for deriving short-term and long-term values of said RCP; means for deriving a difference between said short-term and long-term RCP values and for adjusting the rate of said pulse generating means in accordance therewith; and means responsive to said difference exceeding a threshold value for inhibiting changes in said long-term RCP value.

Claim 10

Dependent Claim 85 words

A rate-responsive pacemaker comprising pulse generating means for generating pulses at a rate; means for coupling said pulse generating means to a patient's heart; means for monitoring a rate control parameter ("RCP"); means for deriving short-term and long-term values of said RCP; means for deriving a difference between said short-term and long-term RCP values and for adjusting the rate of said pulse generating means in accordance therewith; and means responsive to said difference exceeding a threshold value for inhibiting changes in said long-term RCP value.

Claim 11

Dependent Claim 16 words

A rate-responsive pacemaker in accordance with claim 7 wherein said threshold value is a programmable parameter.

Claim 12

Dependent Claim 32 words

A rate-responsive pacemaker in accordance with claim 7 wherein said coupling means is a bipolar lead, and said monitoring means monitors said RCP by performing an electrical measurement using said bipolar lead.

Claim 13

Independent Claim 71 words

A method for determining a patient's minute volume from successive samples of a respiratory impedance signal comprising the steps of determining a zero crossing in the signal by comparing signs of successive samples, averaging the absolute magnitudes of each of successive samples to produce an absolute magnitude average, and averaging selected values of the absolute magnitude average with each selected value being the absolute magnitude average when a zero crossing occurs.

Claim 14

Independent Claim 71 words

A method for determining a patient's minute volume from successive samples of a respiratory impedance signal comprising the steps of determining a zero crossing in the signal by comparing signs of successive samples, averaging the absolute magnitudes of each of successive samples to produce an absolute magnitude average, and averaging selected values of the absolute magnitude average with each selected value being the absolute magnitude average when a zero crossing occurs.

Claim 15

Dependent Claim 44 words

A method in accordance with claim 10 wherein the step of determining a zero crossing comprises ascertaining when at least 60 % of the most recent samples in the last 0.4-1.0 second have a sign opposite that of the signal after last zero crossing.

Claim 16

Dependent Claim 35 words

A method in accordance with claim 11 wherein said samples of said respiratory impedance signal are derived by sampling an electrical blood characteristic which is a function of pleural pressure over a bipolar pacemaker lead.

Claim 17

Independent Claim 62 words

A method for determining a patient's minute volume from successive samples of a respiratory impedance signal comprising the steps of determining a zero crossing in the signal from the signs of successive samples, averaging the absolute magnitudes of successive samples, and averaging samples of said absolute magnitude average that the resulting average is proportional to the rate at which zero crossings occur.

Claim 18

Independent Claim 62 words

A method for determining a patient's minute volume from successive samples of a respiratory impedance signal comprising the steps of determining a zero crossing in the signal from the signs of successive samples, averaging the absolute magnitudes of successive samples, and averaging samples of said absolute magnitude average that the resulting average is proportional to the rate at which zero crossings occur.

Claim 19

Dependent Claim 44 words

A method in accordance with claim 13 wherein the step of determining a zero crossing comprises ascertaining when at least 60% of the most recent samples in the last 0.4-1.0 second have a sign opposite that of the signal after a last zero crossing.

Claim 20

Dependent Claim 35 words

A method in accordance with claim 13 wherein said samples of said respiratory impedance signal are derived by sampling an electrical blood characteristic which is a function of pleural pressure over a bipolar pacemaker lead.

Claim 21

Independent Claim 111 words

A method for setting up a rate-responsive pacemaker having programmable parameters and which is equipped for two-way telemetry, the rate of the pacemaker being determined by a rate-control signal, comprising the steps of placing the patient at rest for an extended interval so that the patient adapts to a non-exercise state, suddenly causing the patient to exercise at a peak level so that the rate-control signal becomes a maximum and telemetering the value thereof to an external programmer, and programming parameter values by telemetering them from the programmer to the pacemaker, the parameter values being calculated as functions of both said maximum rate-control signal and rate values selected by a physician.

Claim 22

Independent Claim 111 words

A method for setting up a rate-responsive pacemaker having programmable parameters and which is equipped for two-way telemetry, the rate of the pacemaker being determined by a rate-control signal, comprising the steps of placing the patient at rest for an extended interval so that the patient adapts to a non-exercise state, suddenly causing the patient to exercise at a peak level so that the rate-control signal becomes a maximum and telemetering the value thereof to an external programmer, and programming parameter values by telemetering them from the programmer to the pacemaker, the parameter values being calculated as functions of both said maximum rate-control signal and rate values selected by a physician.

Claim 23

Dependent Claim 21 words

A method in accordance with claim 16 wherein said rate values selected by a physician are maximum rate and minimum rate.

Claim 24

Dependent Claim 23 words

A method in accordance with claim 16 where said rate-control signal is different for different patients even for the same pacemaker programmed parameters.

Claim 25

Dependent Claim 17 words

The rate responsive pacemaker of claim 2 wherein said reference point is the case of the pacemaker.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1993-02-19	1993-08-21	1994-02-20	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1997-02-19	1997-08-21	1998-02-20	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2001-02-19	2001-08-21	2002-02-20	$7700.00	Window Closed / Lapsed

Minute volume rate-responsive pacemaker

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