US4027038A
Expired / Lapsed
US
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Complement inhibitors
Assignee: Wyeth Holdings LLC
•
Filing: 1976-05-10
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Granted: 1977-05-31
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Expires: 1996-05-10
Abstract
Abstract Naphthalenedisulfonic acid ureides and their salts useful as complement inhibitors.
Inventors
- 👤 Seymour Bernstein
- 👤 Robert Herman Lenhard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:10
CPC Classifications
C; C07; C07C; C07C303/00; C07C303/32
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
73 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR4## wherein x is 1 or 2; y is zero or 1; and A is hydrogen, alkali metal or alkaline earth, with the proviso that A is identical in the same compound and x is only 2 when y is zero.
Claim 2
Independent Claim
73 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR4## wherein x is 1 or 2; y is zero or 1; and A is hydrogen, alkali metal or alkaline earth, with the proviso that A is identical in the same compound and x is only 2 when y is zero.
Claim 3
Independent Claim
57 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR5## wherein x is 1 or 2; and y is zero or 1, with the proviso that x is only 2 when y is zero.
Claim 4
Independent Claim
57 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR5## wherein x is 1 or 2; and y is zero or 1, with the proviso that x is only 2 when y is zero.
Claim 5
Dependent Claim
15 words
The method according to claim 2 wherein the compound is 2,2'-[ureylenebis(m-phenylenecarbonylimino)] di-1,5-naphthalenedisulfonic acid tetrasodium salt.
Claim 6
Dependent Claim
14 words
The method according to claim 2 wherein the compound is 4,4'-[ureylenebis(m-phenylenecarbonylimino)]di-2,7-naphthalenedisulfonic acid tetrasodium salt.
Claim 7
Dependent Claim
14 words
The method according to claim 2 wherein the compound is 4,4'-[ureylenebis(p-phenylenecarbonylimino)]di-1,5-naphthalenedisulfonic acid tetrasodium salt.
Claim 8
Dependent Claim
14 words
The method according to claim 2 wherein the compound is 4,4'-[ureylenebis(m-phenylenecarbonylimino)]di-1,5-naphthalenedisulfonic acid tetrasodium salt.
Claim 9
Dependent Claim
14 words
The method according to claim 2 wherein the compound is 6,6'-[ureylenebis(m-phenylenecarbonylimino)]di-1,3-naphthalenedisulfonic acid tetrasodium salt.
Claim 10
Dependent Claim
14 words
The method according to claim 2 wherein the compound is 7,7'-[ureylenebis(m-phenylenecarbonylimino)]di-1,3-naphthalenedisulfonic acid tetrasodium salt.
Claim 11
Dependent Claim
13 words
The method according to claim 2 wherein the body fluid is blood serum.
Claim 12
Independent Claim
70 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a compound to the formula: ##STR6## wherein x is 1 or 2; y is zero or 1; and A is hydrogen, alkali metal or alkaline earth, with the proviso that A is identical in the same compound and x is only 2 when y is zero.
Claim 13
Independent Claim
70 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a compound to the formula: ##STR6## wherein x is 1 or 2; y is zero or 1; and A is hydrogen, alkali metal or alkaline earth, with the proviso that A is identical in the same compound and x is only 2 when y is zero.
Claim 14
Independent Claim
54 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a compound of the formula: ##STR7## wherein x is 1 or 2; and y is zero or 1, with the proviso that x is only 2 when y is zero.
Claim 15
Independent Claim
54 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a compound of the formula: ##STR7## wherein x is 1 or 2; and y is zero or 1, with the proviso that x is only 2 when y is zero.
Claim 16
Dependent Claim
12 words
The method according to claim 11 wherein the compound is administered intra-articularly.
Claim 17
Dependent Claim
15 words
The method according to claim 11 wherein the compound is 2,2'-[ureylenebis(m-phenylenecarbonylimino)]di- 1,5-naphthalenedisulfonic acid tetrasodium salt.
Claim 18
Dependent Claim
14 words
The method according to claim 11 wherein the compound is 4,4'-[ureylenebis(m-phenylenecarbonylimino)]di-2,7-naphthalenedisulfonic acid tetrasodium salt.
Claim 19
Dependent Claim
14 words
The method according to claim 11 wherein the compound is 4,4'-[ureylenebis(p-phenylenecarbonylimino)]di-1,5-naphthalenedisulfonic acid tetrasodium salt.
Claim 20
Dependent Claim
14 words
The method according to claim 11 wherein the compound is 4,4'-[ureylenebis(m-phenylenecarbonylimino)]di-1,5-naphthalenedisulfonic acid tetrasodium salt.
Claim 21
Dependent Claim
14 words
The method according to claim 11 wherein the compound is 6,6'-[ureylenebis(m-phenylenecarbonylimino)]di-1,3-naphthalenedisulfonic acid tetrasodium salt.
Claim 22
Dependent Claim
14 words
The method according to claim 11 wherein the compound is 7,7'-[ureylenebis(m-phenylenecarbonylimino)]di-1,3-naphthalenedisulfonic acid tetrasodium salt.
References Cited (Backward Citations)
US3897434A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-30 | 1980-11-29 | 1981-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-30 | 1984-11-29 | 1985-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-30 | 1988-11-29 | 1989-05-31 | $7700.00 | Window Closed / Lapsed |