Patent US4866096A successfully refreshed from Google Patents.
US4866096A
Expired / Lapsed
US
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Stable fluorochemical aqueous emulsions
Assignee: Versum Materials US LLC
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Filing: 1987-03-20
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Granted: 1989-09-12
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Expires: 2007-03-20
Abstract
Abstract A stable aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood.
Inventors
- 👤 Frank K. Schweighardt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:57
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/0012; A61K9/0019; A61K9/0026; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/125; A61P; A61P7/00; A61P7/08
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
48 words
A stable aqueous emulsion of a perfluorochemical comprising approximately 10-50 weight/volume % perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids as an emulsifier adjuvant, and the remainder of an aqueous medium.
Claim 2
Dependent Claim
48 words
A stable aqueous emulsion of a perfluorochemical comprising approximately 10-50 weight/volume % perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids as an emulsifier adjuvant, and the remainder of an aqueous medium.
Claim 3
Dependent Claim
29 words
The emulsion of claim 1 wherein the perfluorochemical is selected from the group consisting of perfluoroalkylcyclohexane having 3 to 5 carbon atoms in the alkyl radical, perfluorodecalin or perfluoromethyldecalin.
Claim 4
Dependent Claim
10 words
The emulsion of claim 1 wherein the perfluorochemical is perfluorodecalin.
Claim 5
Dependent Claim
19 words
The emulsion of claim 1 wherein the perfluorochemical is present in the range of 20 to 40 weight/volume %.
Claim 6
Dependent Claim
12 words
The emulsion of claim 1 wherein the phospholipid is an egg phosphatide.
Claim 7
Dependent Claim
17 words
The emulsion of claim 1 wherein the phospholipid is present in a range of 1-2 weight percent.
Claim 8
Dependent Claim
28 words
The emulsion of claim 1 wherein the triglyceride emulsifier adjuvant of of fatty acids is selected from the group consisting of safflower oil, soybean oil or mixtures thereof.
Claim 9
Dependent Claim
25 words
The emulsion of claim 1 wherein the triglyceride emulsifier adjuvant of of fatty acids is present in the range of 10 to 20 weight %.
Claim 10
Dependent Claim
9 words
The emulsion of claim 1 including an albumin component.
Claim 11
Dependent Claim
107 words
A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferable saturated perfluorodecalin having essentially no detectable hydrogen or olefinic character and a mean particle size of about 0.15 microns which comprises said perfluorodecalin in a concentration of 10 to 50 weight/volume %, a phospholipid as an emulsifier in a concentration of approximately 1.2 weight %, at least one triglyceride of fatty acids as an emulsifier adjuvant in a concentration of 10 to 20 weight % wherein the fatty acids have 16 to 18 carbon atoms, and glycerin in an amount of approximately 2.5 weight %, said emulsion being suitable for use as a blood substitute.
Claim 12
Dependent Claim
107 words
A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferable saturated perfluorodecalin having essentially no detectable hydrogen or olefinic character and a mean particle size of about 0.15 microns which comprises said perfluorodecalin in a concentration of 10 to 50 weight/volume %, a phospholipid as an emulsifier in a concentration of approximately 1.2 weight %, at least one triglyceride of fatty acids as an emulsifier adjuvant in a concentration of 10 to 20 weight % wherein the fatty acids have 16 to 18 carbon atoms, and glycerin in an amount of approximately 2.5 weight %, said emulsion being suitable for use as a blood substitute.
Claim 13
Independent Claim
105 words
A method of enhancing the transport of oxygen through the vascular system and into the tissue of mammals which comprises administering a volumetric amount of a perfluorochemical emulsion to said mammal sufficient to maintain the total vascular volume of said mammal and subjecting the respiratory function of the mammal to elevated concentrations of oxygen above atmospheric concentrations wherein said emulsion comprises approximately 10 to 50 weight/volume % of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids as an emulsifier adjuvant, and the remainder of an aqueous medium.
Claim 14
Independent Claim
105 words
A method of enhancing the transport of oxygen through the vascular system and into the tissue of mammals which comprises administering a volumetric amount of a perfluorochemical emulsion to said mammal sufficient to maintain the total vascular volume of said mammal and subjecting the respiratory function of the mammal to elevated concentrations of oxygen above atmospheric concentrations wherein said emulsion comprises approximately 10 to 50 weight/volume % of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids as an emulsifier adjuvant, and the remainder of an aqueous medium.
Claim 15
Independent Claim
64 words
A method of preserving internal organs outside the body which comprises perfusing the same with a preoxygenated perfluorochemical emulsion comprising approximately 10 to 50 weight/volume % of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids as an emulsifier adjuvant, and the remainder of an aqueous medium.
Claim 16
Independent Claim
64 words
A method of preserving internal organs outside the body which comprises perfusing the same with a preoxygenated perfluorochemical emulsion comprising approximately 10 to 50 weight/volume % of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids as an emulsifier adjuvant, and the remainder of an aqueous medium.
Claim 17
Dependent Claim
85 words
In a method for preparing a stable aqueous emulsion of a perfluorochemical in a perfluorochemical concentration range of approximately 10-50 wt/vol% wherein an aqueous emulsifier is mixed with a perfluorochemical to result in a final aqueous perfluorochemical emulsion having a perfluorochemical concentration in the range of 10 to 50 wt/vol% the improvement comprising using a perfluorochemical that is prepared by an initial fluorination of a chemical in the presence of cobalt trifluoride and subsequent complete fluorination of said chemical in the presence of elemental fluorine.
Claim 18
Dependent Claim
85 words
In a method for preparing a stable aqueous emulsion of a perfluorochemical in a perfluorochemical concentration range of approximately 10-50 wt/vol% wherein an aqueous emulsifier is mixed with a perfluorochemical to result in a final aqueous perfluorochemical emulsion having a perfluorochemical concentration in the range of 10 to 50 wt/vol% the improvement comprising using a perfluorochemical that is prepared by an initial fluorination of a chemical in the presence of cobalt trifluoride and subsequent complete fluorination of said chemical in the presence of elemental fluorine.
Claim 19
Dependent Claim
82 words
A stable aqueous emulsion of a perfluorochemical comprising approximately 10-50 weight/volume % perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids as an emulsifying adjuvant comprising an approximately 50/50 mixture of safflower oil and soybean oil having a fatty acid composition of approximately 65.8% linoleic acid, 17.7% oleic acid, 8.8% palmitic acid, 3.4% stearic acid and 4.2% linolenic acid, and the remainder of an aqueous medium.
Claim 20
Dependent Claim
82 words
A stable aqueous emulsion of a perfluorochemical comprising approximately 10-50 weight/volume % perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids as an emulsifying adjuvant comprising an approximately 50/50 mixture of safflower oil and soybean oil having a fatty acid composition of approximately 65.8% linoleic acid, 17.7% oleic acid, 8.8% palmitic acid, 3.4% stearic acid and 4.2% linolenic acid, and the remainder of an aqueous medium.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-11 | 1993-03-13 | 1993-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-11 | 1997-03-13 | 1997-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-11 | 2001-03-13 | 2001-09-12 | $7700.00 | Window Closed / Lapsed |