Patent US4863907A successfully refreshed from Google Patents.
US4863907A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Crosslinked glycosaminoglycans and their use
Assignee: Seikagaku Corp
•
Filing: 1985-06-25
•
Granted: 1989-09-05
•
Expires: 2005-06-25
Abstract
Abstract Crosslinked glycosaminoglycans or salts thereof prepared by crosslinking glycosaminoglycan or salts thereof with a polyfunctional epoxy compound wherein a crosslinking index is 0.005 or more per 1 mole of repeating disaccharides in glycosaminoglycan, and having various medical and cosmetic uses.
Inventors
- 👤 Katukiyo Sakurai
- 👤 Yoshio Ueno
- 👤 Takashi Okuyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:14
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/73; A61K8/735; A61K9/00; A61K9/70; A61L; A61L31/00; A61L31/04; A61L31/042; A61L31/043; A61L31/044; A61Q; A61Q19/00; C08B37/0072; C08L; C08L5/00; C08L5/08
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
67 words
A crosslinked glycosaminoglycan or a salt thereof obtainable by crosslinking a glycosaminoglycan (provided that hyaluronic acid is excluded) or a salt thereof with a polyfunctional epoxy compound wherein a crosslinking index is 0.005 or more per 1 mole of repeating disaccharides in said glycosaminoglucan and wherein said glycosaminoglycan is chondroitin sulfate, heparin, heparan sulfate, keratan sulfate or keratanpolysulfate and said polyfunctional epoxy compound is epichlorohydrin or epibromohydrin.
Claim 2
Dependent Claim
67 words
A crosslinked glycosaminoglycan or a salt thereof obtainable by crosslinking a glycosaminoglycan (provided that hyaluronic acid is excluded) or a salt thereof with a polyfunctional epoxy compound wherein a crosslinking index is 0.005 or more per 1 mole of repeating disaccharides in said glycosaminoglucan and wherein said glycosaminoglycan is chondroitin sulfate, heparin, heparan sulfate, keratan sulfate or keratanpolysulfate and said polyfunctional epoxy compound is epichlorohydrin or epibromohydrin.
Claim 3
Dependent Claim
34 words
The crosslinked glycosaminoglycan or a salt thereof as claimed in claim 1 wherein it has a crosslinking index of 0.165 or more per 1 mole of repeating disaccharides in said glycosaminoglycan and is water-insoluble.
Claim 4
Dependent Claim
57 words
A pharmaceutical composition for applying to vitreous body comprising an active ingredient in combination with an ophthamologically acceptable carrier or diluent, wherein said active ingredient is a crosslinked glycosaminoglycan or a salt thereof as claimed in claim 1 and is present in such an amount that the viscosity of the composition is not more than 50,000 cp.
Claim 5
Dependent Claim
13 words
The composition of claim 3 wherein the viscosity is at least 5,000 cp.
Claim 6
Dependent Claim
13 words
The composition of claim 3 wherein the viscosity is 5,000 to 30,000 cp.
Claim 7
Dependent Claim
31 words
A pharmaceutical composition for applying to a wound for healing, comprising a wound healing effective amount of the crosslinked glycosaminoglycan or salt thereof, of claim 1, in a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
22 words
The pharmaceutical composition of claim 6 comprising a 2% solution of the crosslinked glycosaminoglycan or salt thereof in a physiological saline solution.
References Cited (Backward Citations)
US3507851A
Cited
US3829412A
Cited
US4098859A
Cited
US4470975A
Cited
JPS57185208A
Cited
JPS6084225A
Cited
US4532267A
Cited
US4582865A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-04 | 1993-03-06 | 1993-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-04 | 1997-03-06 | 1997-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-04 | 2001-03-06 | 2001-09-05 | $7700.00 | Window Closed / Lapsed |