Patent US4850998A successfully refreshed from Google Patents.
US4850998A
Expired / Lapsed
US
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Method for wetting a plasmapheresis filter with anticoagulant
Assignee: Baxter International Inc
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Filing: 1987-10-07
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Granted: 1989-07-25
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Expires: 2007-10-07
Abstract
Abstract A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle, a plasma separation device connected in series by a fluid conduit, including operating the system such that an initial limited volume charge of anticoagulant is introduced into the conduit (for wetting the filter of the separation device) in advance of whole blood flowing from the donor towards to the separation device (and pushing the anticoagulant charge ahead of the whole blood into the separation device).
Inventors
- 👤 Donald W. Schoendorfer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:50
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3672
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
124 words
A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle and a plasma separation device including a plasmapheresis filter, the needle and separation device being connected by a fluid conduit, comprising the steps of: providing said conduit with a predetermined amount of anticoagulant of insufficient quantity in said conduit to reach the separation device; performing the venepuncture to provide the conduit with whole blood from a donor; and pumping the whole blood in said conduit to advance the predetermined amount of anticoagulant along said conduit such that the predetermined amount of anticoagulant is provided said separation device first and in advance of the whole blood to wet the plasmapheresis filter before the whole blood contacts the filter.
Claim 2
Independent Claim
124 words
A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle and a plasma separation device including a plasmapheresis filter, the needle and separation device being connected by a fluid conduit, comprising the steps of: providing said conduit with a predetermined amount of anticoagulant of insufficient quantity in said conduit to reach the separation device; performing the venepuncture to provide the conduit with whole blood from a donor; and pumping the whole blood in said conduit to advance the predetermined amount of anticoagulant along said conduit such that the predetermined amount of anticoagulant is provided said separation device first and in advance of the whole blood to wet the plasmapheresis filter before the whole blood contacts the filter.
Claim 3
Dependent Claim
41 words
A method according to claim 1 wherein the system includes a blood pump between the venepuncture needle and the separation device, and including the further step of providing the anticoagulant at a location between the venepuncture needle and the blood pump.
Claim 4
Dependent Claim
53 words
A method according to claim 1 including pumping a predetermined amount of anticoagulant into said conduit, detecting the presence of said predetermined amount of anticoagulant in said conduit, providing a signal in response to said detection and discontinuing the pumping of anticoagulant in response to said signal and prior to performing the venepuncture.
Claim 5
Dependent Claim
24 words
A method according to claim 3 wherein the last four steps of pumping, detecting, providing and discontinuing pumping are performed prior to performing venepuncture.
Claim 6
Dependent Claim
35 words
A method according to claim 3 wherein the system includes a reservoir for collecting and reinfusing cell concentrate and including the further step of providing anticoagulated whole blood to the reservoir to prime the latter.
Claim 7
Dependent Claim
32 words
A method according to claim 1 including flowing a portion of the predetermined amount of anticoagulant into the reservoir from the separation device, said anticoagulant portion being less than about 5 ml.
Claim 8
Dependent Claim
13 words
A method according to claim 1 wherein said predetermined amount comprises solely anticoagulant.
Claim 9
Independent Claim
128 words
A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle and a plasma separation device including a plasmapheresis filter, the needle and separation device lying in communication with one another, comprising the steps of: providing the system between the needle and the separation device with an initial charge of anticoagulant of insufficient quantity for flow to the separation device; performing the venepuncture to provide the system with whole blood from the donor for flow to the separation device; and operating the system such that the initial charge of anticoagulant flows immediately ahead of the flow of whole blood so that the anticoagulant wets the filter of the separation device before the whole blood from the donor flows to the separation device.
Claim 10
Independent Claim
128 words
A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle and a plasma separation device including a plasmapheresis filter, the needle and separation device lying in communication with one another, comprising the steps of: providing the system between the needle and the separation device with an initial charge of anticoagulant of insufficient quantity for flow to the separation device; performing the venepuncture to provide the system with whole blood from the donor for flow to the separation device; and operating the system such that the initial charge of anticoagulant flows immediately ahead of the flow of whole blood so that the anticoagulant wets the filter of the separation device before the whole blood from the donor flows to the separation device.
Claim 11
Dependent Claim
23 words
A method according to claim 8 wherein the step of performing venepuncture is accomplished before the system is operated to wet the filter.
Claim 12
Dependent Claim
53 words
A method according to claim 8 including pumping a predetermined amount of anticoagulant into said system, detecting the presence of said predetermined amount of anticoagulant in said system, providing a signal in response to said detection and discontinuing the pumping of anticoagulant in response to said signal and prior to performing the venepuncture.
Claim 13
Dependent Claim
24 words
A method according to claim 10 wherein the last four steps of pumping, detecting, providing and discontinuing pumping are performed prior to performing venepuncture.
Claim 14
Dependent Claim
35 words
A method according to claim 10 wherein the system includes a reservoir for collecting and reinfusing cell concentrate and including the further step of providing anticoagulated whole blood to the reservoir to prime the latter.
Claim 15
Dependent Claim
50 words
A method according to claim 8 wherein the system includes a reservoir for containing cell concentrate separated by the separation device, including the further step of flowing at least a portion of the initial charge of anticoagulant into said reservoir from (the separation device) after the filter is wetted thereby.
Claim 16
Dependent Claim
28 words
A method according to claim 13 including operating the system to flow the cell concentrate and the initial charge of anticoagulant in the reservoir to the blood donor.
Claim 17
Dependent Claim
13 words
A method according to claim 8 wherein said initial charge comprises solely anticoagulant.
Claim 18
Independent Claim
203 words
A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle and a plasma separation device connected by a fluid conduit, comprising the steps of: pumping a predetermined amount of anticoagulant into said conduit, detecting the presence of said predetermined amount of anticoagulant in said conduit, providing a signal in response to said detection and discontinuing the pumping of anticoagulant in response to said signal and prior to performing venepuncture; performing the venepuncture to provide the conduit with whole blood from a donor; pumping the whole blood in said conduit such that the predetermined amount of anticoagulant in said conduit is provided said separation device first and in advance of the whole blood to wet the plasmapheresis filter before the whole blood contacts the filter; and the steps of pumping, detecting and discontinuing pumping being performed prior to performing venepuncture and, subsequent to venepuncture, the further steps of detecting the presence of a predetermined amount of anticoagulant and whole blood in said conduit sufficient such that the predetermined amount of anticoagulant has reached the filter and providing a signal in response thereto, and diverting whole blood to a cell concentrate and reinfusing reservoir to prime the latter.
Claim 19
Independent Claim
203 words
A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle and a plasma separation device connected by a fluid conduit, comprising the steps of: pumping a predetermined amount of anticoagulant into said conduit, detecting the presence of said predetermined amount of anticoagulant in said conduit, providing a signal in response to said detection and discontinuing the pumping of anticoagulant in response to said signal and prior to performing venepuncture; performing the venepuncture to provide the conduit with whole blood from a donor; pumping the whole blood in said conduit such that the predetermined amount of anticoagulant in said conduit is provided said separation device first and in advance of the whole blood to wet the plasmapheresis filter before the whole blood contacts the filter; and the steps of pumping, detecting and discontinuing pumping being performed prior to performing venepuncture and, subsequent to venepuncture, the further steps of detecting the presence of a predetermined amount of anticoagulant and whole blood in said conduit sufficient such that the predetermined amount of anticoagulant has reached the filter and providing a signal in response thereto, and diverting whole blood to a cell concentrate and reinfusing reservoir to prime the latter.
Claim 20
Independent Claim
191 words
A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle and a plasma separation device, comprising the steps of: pumping a predetermined amount of anticoagulant into said system, detecting the presence of said predetermined amount of anticoagulant in said system, providing a signal in response to said detection and discontinuing the pumping of anticoagulant in response to said signal and prior to performing venepuncture; performing the venepuncture to provide the system with whole blood from the donor for flow to the separation device; and operating the system such that the initial charge of anticoagulant wets the filter of the separation device before the whole blood from the donor flows to the separation device; the steps of pumping, detecting and discontinuing pumping being performed prior to performing venepuncture and, subsequent to venepuncture, the further steps of detecting the presence of a predetermined amount of anticoagulant and whole blood in said system sufficient such that the predetermined amount of anticoagulant has reached the filter and providing a signal in response thereto, and diverting whole blood to a cell concentrate and reinfusing reservoir to prime the latter.
Claim 21
Independent Claim
191 words
A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle and a plasma separation device, comprising the steps of: pumping a predetermined amount of anticoagulant into said system, detecting the presence of said predetermined amount of anticoagulant in said system, providing a signal in response to said detection and discontinuing the pumping of anticoagulant in response to said signal and prior to performing venepuncture; performing the venepuncture to provide the system with whole blood from the donor for flow to the separation device; and operating the system such that the initial charge of anticoagulant wets the filter of the separation device before the whole blood from the donor flows to the separation device; the steps of pumping, detecting and discontinuing pumping being performed prior to performing venepuncture and, subsequent to venepuncture, the further steps of detecting the presence of a predetermined amount of anticoagulant and whole blood in said system sufficient such that the predetermined amount of anticoagulant has reached the filter and providing a signal in response thereto, and diverting whole blood to a cell concentrate and reinfusing reservoir to prime the latter.
References Cited (Backward Citations)
US4191182A
Cited
WO1981002979A1
Cited
US4605503A
Cited
US4648866A
Cited
US4657529A
Cited
US4578056A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-24 | 1993-01-23 | 1993-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-24 | 1997-01-23 | 1997-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-24 | 2001-01-23 | 2001-07-25 | $7700.00 | Window Closed / Lapsed |