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US4822777A
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Amphotericin B/cholesterol sulfate composition
Assignee: Intermune Inc
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Filing: 1987-02-27
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Granted: 1989-04-18
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Expires: 2007-02-27
Abstract
Abstract An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between about 100-400 nm. The composition formed at a molar ratio of about 1:1 amphotericin B:cholesterol sulfate ahs stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infection than prior amphotericin B formulations.
Inventors
- 👤 Robert Abra
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:23
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K47/00; A61K47/06; A61K47/28; A61K9/00; A61K9/0012; A61K9/0019; A61K9/48; A61K9/50; A61K9/51; A61K9/5107; A61K9/5123; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
28 words
An amphotericin B composition comprising particles of amphotericin B containing cholesterol sulfate in a mole ratio of amphotericin B to cholesterol sulfate of between about 1:1 to 1:4.
Claim 2
Dependent Claim
28 words
An amphotericin B composition comprising particles of amphotericin B containing cholesterol sulfate in a mole ratio of amphotericin B to cholesterol sulfate of between about 1:1 to 1:4.
Claim 3
Dependent Claim
23 words
The composition of claim 1, wherein the particles are suspended in an aqueous medium, and have particle sizes predominantly between about 100-400 nm.
Claim 4
Dependent Claim
18 words
The composition of claim 1, wherein the molar ratio of amphotericin B to cholesterol sulfate is about 1:1.
References Cited (Backward Citations)
US4002741A
Cited
US4468513A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-17 | 1992-10-17 | 1993-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-17 | 1996-10-17 | 1997-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-17 | 2000-10-17 | 2001-04-18 | $7700.00 | Window Closed / Lapsed |