Patent US4822335A successfully refreshed from Google Patents.
US4822335A
Expired / Lapsed
US
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Apparatus for treatment of cancer with photodiode
Assignee: Kureha Corp
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Filing: 1987-09-08
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Granted: 1989-04-18
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Expires: 2007-09-08
Abstract
Abstract Apparatus for the treatment of a cancerous lesion part by irradiating a light energy from a light source to the cancerous lesion part having absorbed and accumulated in advance therein a photosensitive substance with an affinity for tumors, in which said light source comprises a first photodiode adapted to excite the photosensitive substance from the ground state thereof to a singlet state of higher energy level and a second photodiode adapted to exite an energy level of the photosensitive substance which has transited from the singlet state to a triplet state to a still higher energy level.
Inventors
- 👤 Yoshio Kawai
- 👤 Kazue Endo
- 👤 Makoto Yoshimura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:37
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; A61N; A61N5/00; A61N5/06; A61N5/0613; A61N5/062; A61N5/067; A61B2018/208; A61N2005/0635; A61N2005/0643; A61N2005/0645; A61N2005/065; A61N2005/0651; A61N2005/0652; A61N5/0601
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
153 words
Apparatus for treatment of a cancerous lesion part with a light energy which is irradiated from a light source to said cancerous lesion part having absorbed and accumulated in advance therein a photosensitive substance with an affinity for tumors, wherein said light source comprises a first photodiode adapted to excite said photosensitive substance from the ground state thereof to a singlet state of a higher energy level and a second photodiode adapted to excite an energy level of said photosensitive substance which has transited from said singlet state to a triplet state to a still higher energy level, wherein a plurality of pairs of first and second photodiodes are disposed on a curved surface of a spherical-segment shaped support member along the bottom periphery of said support member and projected radially outwardly from said curved surface, any two randomly selected adjacent photodiodes constituting a pair of a first photodiode and a second photodiode.
Claim 2
Dependent Claim
153 words
Apparatus for treatment of a cancerous lesion part with a light energy which is irradiated from a light source to said cancerous lesion part having absorbed and accumulated in advance therein a photosensitive substance with an affinity for tumors, wherein said light source comprises a first photodiode adapted to excite said photosensitive substance from the ground state thereof to a singlet state of a higher energy level and a second photodiode adapted to excite an energy level of said photosensitive substance which has transited from said singlet state to a triplet state to a still higher energy level, wherein a plurality of pairs of first and second photodiodes are disposed on a curved surface of a spherical-segment shaped support member along the bottom periphery of said support member and projected radially outwardly from said curved surface, any two randomly selected adjacent photodiodes constituting a pair of a first photodiode and a second photodiode.
Claim 3
Dependent Claim
199 words
Apparatus for treatment of a cancerous lesion part with a light energy which is irradiated from a light source to said cancerous lesion part having absorbed and accumulated in advance therein a photosensitive substance with an affinity for tumors, wherein said light source comprises a first photodiode adapted to excite said photosensitive substance from the ground state thereof to a singlet state of a higher energy level and a second photodiode adapted to excite an energy level of said photosensitive substance which has transited from said signlet state to a triplet state to a still higher energy level, wherein a plurality of pairs of first and second photodiodes are disposed on a surface on the side of one end of a flexible support member, in a row of photodiodes in a longitudinal direction of the flexible support member and the row of photodiodes in the direction perpendicular to said longitudinal direction, first photodiodes and second photodiodes are invariable positioned adjacently, said first and second photodiodes are surrounded with a freely expansible and contractive balloon fastened at the opposite ends thereof to said support member, said balloon being provided with a flow path for introduction and discharge of a coolant.
Claim 4
Dependent Claim
199 words
Apparatus for treatment of a cancerous lesion part with a light energy which is irradiated from a light source to said cancerous lesion part having absorbed and accumulated in advance therein a photosensitive substance with an affinity for tumors, wherein said light source comprises a first photodiode adapted to excite said photosensitive substance from the ground state thereof to a singlet state of a higher energy level and a second photodiode adapted to excite an energy level of said photosensitive substance which has transited from said signlet state to a triplet state to a still higher energy level, wherein a plurality of pairs of first and second photodiodes are disposed on a surface on the side of one end of a flexible support member, in a row of photodiodes in a longitudinal direction of the flexible support member and the row of photodiodes in the direction perpendicular to said longitudinal direction, first photodiodes and second photodiodes are invariable positioned adjacently, said first and second photodiodes are surrounded with a freely expansible and contractive balloon fastened at the opposite ends thereof to said support member, said balloon being provided with a flow path for introduction and discharge of a coolant.
Claim 5
Dependent Claim
24 words
The apparatus according to claim 2, wherein said flow path for introduction and discharge of a coolant is disposed inside said flexible support member.
Claim 6
Independent Claim
22 words
The apparatus according to any one of claims 1, 2 or 3, wherein said first and second photodiodes are respectively laser diodes.
Claim 7
Independent Claim
22 words
The apparatus according to any one of claims 1, 2 or 3, wherein said first and second photodiodes are respectively light-emitting diodes.
Claim 8
Dependent Claim
21 words
The apparatus according to claim 5, wherein said first photodiodes are light-emitting diodes of GaAsP having a wavelength of 630 nm.
Claim 9
Dependent Claim
21 words
The apparatus according to claim 5, wherein said second photodiodes are light-emitting diodes of GaP having a wavelength of 690 nm.
Claim 10
Dependent Claim
30 words
The apparatus according to claim 1, wherein said light source is connected to a power source through a circuit part adapted to control an overcurrent flowing to said light source.
Claim 11
Dependent Claim
14 words
The apparatus according to claim 8, wherein said circuit part comprises a protective resistance.
Claim 12
Dependent Claim
24 words
The apparatus according to claim 1, wherein said light source comprises a plurality of first and second photodiodes, which are alternately connected in series.
Claim 13
Dependent Claim
22 words
The apparatus according to claim 1, which is provided with cooling means adapted to remove a heat generated in said light source.
Claim 14
Dependent Claim
150 words
Apparatus for treatment of a cancerous lesion part with a light energy which is irradiated from a light source to said cancerous lesion part having absorbed and accumulated in advance in said lesion part a photosensitive substance with an affinity to tumors, wherein said light source comprises a first photodiode for emitting a first light which excites said photosensitive substance from the ground state of said photosensitive substance to a singlet state of a higher energy level than said ground state, and a second photodiode for emitting a second light simultaneously with said first light source, which excites an energy level of said photosensitive substance, which has transited from said singlet state to a triplet state, to a higher energy level than said triplet state, said light source being so adapted as to irradiate to said lesion part both first and second lights for the treatment of said lesion part.
Claim 15
Dependent Claim
150 words
Apparatus for treatment of a cancerous lesion part with a light energy which is irradiated from a light source to said cancerous lesion part having absorbed and accumulated in advance in said lesion part a photosensitive substance with an affinity to tumors, wherein said light source comprises a first photodiode for emitting a first light which excites said photosensitive substance from the ground state of said photosensitive substance to a singlet state of a higher energy level than said ground state, and a second photodiode for emitting a second light simultaneously with said first light source, which excites an energy level of said photosensitive substance, which has transited from said singlet state to a triplet state, to a higher energy level than said triplet state, said light source being so adapted as to irradiate to said lesion part both first and second lights for the treatment of said lesion part.
Claim 16
Dependent Claim
61 words
The apparatus according to claim 12, wherein a plurality of pairs of first and second photodiodes are disposed on a curved surface of a spherical-segment shaped support member along the bottom periphery of said support member and projected radially outwardly from said curved surface, any two randomly selected adjacent photodiodes constituting a pair of a first photodiode and a second photodiode.
Claim 17
Dependent Claim
106 words
The apparatus according to claim 12, wherein a plurality of pairs of first and second photodiodes are disposed on a surface on the side of one end of a flexible support member, in a row of photodiodes in a longitudinal direction of the flexible support member and a row of photodiodes in the direction perpendicular to said longitudinal direction, first photodiodes and second photodiodes are invariably positioned adjacently, said first and second photodiodes are surrounded with a freely expansible and contractive balloon fastened at the opposite ends thereof to said support members, said balloon being provided with flow path for introduction and discharge of a coolant.
Claim 18
Dependent Claim
24 words
The apparatus according to claim 14, wherein said flow path for introduction and discharge of a coolant is disposed inside said flexible support member.
Claim 19
Independent Claim
21 words
The apparatus according to any one of claims 12 to 16, wherein said first and second photodiodes are respectively laser diodes.
Claim 20
Independent Claim
21 words
The apparatus according to any one of claims 12 to 15, wherein said first and second photodiodes are respectively light-emitting diodes.
Claim 21
Dependent Claim
21 words
The apparatus according to claim 17, wherein said first photodiodes are light-emitting diodes of GaAsP having a wave-length of 630 nm.
Claim 22
Dependent Claim
21 words
The apparatus according to claim 17, wherein said second photodiodes are light-emitting diodes of GaP having a wavelength of 690 nm.
Claim 23
Dependent Claim
30 words
The apparatus according to claim 12, wherein said light source is connected to a power source through a circuit part adapted to control an overcurrent flowing to said light source.
Claim 24
Dependent Claim
14 words
The apparatus according to claim 20, wherein said circuit part comprises a protective resistance.
Claim 25
Dependent Claim
24 words
The apparatus according to claim 12, wherein said light source comprises a plurality of first and second photodiodes, which are alternately connected in series.
Claim 26
Dependent Claim
22 words
The apparatus according to claim 12, which is provided with cooling means adapted to remove a heat generated in said light source.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-17 | 1992-10-17 | 1993-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-17 | 1996-10-17 | 1997-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-17 | 2000-10-17 | 2001-04-18 | $7700.00 | Window Closed / Lapsed |