Patent US4820261A successfully refreshed from Google Patents.
US4820261A
Expired / Lapsed
US
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Device for the removal of therapeutic substances locally applied for use against solid tumors
Assignee: Pharma Biotechnologie Hannover GmbH
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Filing: 1987-08-19
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Granted: 1989-04-11
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Expires: 2007-08-19
Abstract
Abstract A device for the removal of active substances locally applied against solid tumors consists of a catheter (1) to be positioned distally to the tumor for the collection of blood coming from the tumor, a pump (2) anda catheter (3) connected thereto and returning the blood into the body. The device is characterized in that between the two catheters (1, 3) there is present at least one container (4) capable of allowing blood to pass therethrough and containing immobilized antibodies against the applied active substance.
Inventors
- 👤 Hans-Joachim Schmoll
- 👤 Ekkehard Schmoll
- 👤 Edmund R. Lax
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:04
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/1011; A61M1/00; A61M1/36; A61M1/3615; A61M1/3679; A61M25/01; A61M25/0105; A61M25/0108
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
170 words
A device for removing a substance from the human circulatory system comprising (a) a first catheter having one end positionable in a blood vessel distally from a tumor for removing blood from the vessel, (b) a second catheter having one end positionable in the blood vessel for returning blood to the vessel and forming with the first catheter a double catheter along at least part of their length such that the one end of the first catheter is joined to the second catheter at a distance from the one end of the second catheter, (c) a pump connected to the first and second catheters, (d) at least one container holding immobilized antibodies to the substance and connected to the first and second catheters such that blood passes from the first catheter to the second catheter through the container, and (e) an inflatable balloon for blocking the blood vessel when inflated and located on the second catheter between the end of the first catheter and the end of the second catheter.
Claim 2
Independent Claim
170 words
A device for removing a substance from the human circulatory system comprising (a) a first catheter having one end positionable in a blood vessel distally from a tumor for removing blood from the vessel, (b) a second catheter having one end positionable in the blood vessel for returning blood to the vessel and forming with the first catheter a double catheter along at least part of their length such that the one end of the first catheter is joined to the second catheter at a distance from the one end of the second catheter, (c) a pump connected to the first and second catheters, (d) at least one container holding immobilized antibodies to the substance and connected to the first and second catheters such that blood passes from the first catheter to the second catheter through the container, and (e) an inflatable balloon for blocking the blood vessel when inflated and located on the second catheter between the end of the first catheter and the end of the second catheter.
Claim 3
Dependent Claim
21 words
A device according to claim 1 further comprising a second balloon located on the double catheter for blocking the blood vessel.
Claim 4
Dependent Claim
27 words
Device according to claim 1, characterized in that the immobilized antibody present in the container is directed against active substances of blood cells and/or blood cell precursors.
Claim 5
Dependent Claim
22 words
Device according to claim 1, characterized in that the immobilized antibody present in the container is active against lymphokines, monokines and/or cytokines.
Claim 6
Dependent Claim
31 words
Device according to claims 1, characterized in that the immobilized antibody present in the container is directed against interferons, interleukins, colony stimulating factors, tumour necrosis factor, lymphotoxin and/or transforming growth factors.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-10 | 1992-10-10 | 1993-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-10 | 1996-10-10 | 1997-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-10 | 2000-10-10 | 2001-04-11 | $7700.00 | Window Closed / Lapsed |