Patent US4810378A successfully refreshed from Google Patents.
US4810378A
Expired / Lapsed
US
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Red blood cell filtering system
Assignee: Bayer Corp
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Filing: 1987-05-26
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Granted: 1989-03-07
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Expires: 2007-05-26
Abstract
Abstract Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.
Inventors
- 👤 Raleigh A. Carmen
- 👤 Chiyong Chong
- 👤 Barry S. Leng
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:56
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
105 words
In a closed multiple blood bag system comprising two flexible plastic bags in closed communication with each other via connecting plastic tubing, the improvement comprising a filter disposed between the two bags and continuous with the connecting tubing, the filter comprising a housing tapered in one direction and containing continuous filtering fiber having a denier of about 2.2, the filter adapted to permit substantial removal of white blood cells from a mixture of red and white blood blood cells with minimal red blood cell hemolysis when the mixture is passed from one bag to the other through the filter at a relatively high flow rate.
Claim 2
Dependent Claim
105 words
In a closed multiple blood bag system comprising two flexible plastic bags in closed communication with each other via connecting plastic tubing, the improvement comprising a filter disposed between the two bags and continuous with the connecting tubing, the filter comprising a housing tapered in one direction and containing continuous filtering fiber having a denier of about 2.2, the filter adapted to permit substantial removal of white blood cells from a mixture of red and white blood blood cells with minimal red blood cell hemolysis when the mixture is passed from one bag to the other through the filter at a relatively high flow rate.
Claim 3
Dependent Claim
28 words
The system of claim 1 wherein the continuous filtering fiber has a fiber length of greater than about 1000 meters, and an average fiber diameter of 20±5 μm.
Claim 4
Dependent Claim
20 words
The system of claim 1 wherein the filtering fiber has a density of about 0.4 to 0.7 grams per cc.
Claim 5
Dependent Claim
33 words
The system of claim 1 wherein the filter housing has a volume of less than about 50 cc and the filtering fiber has a generally Y-shaped cross sectional area and is cellulose acetate.
Claim 6
Dependent Claim
17 words
The system of claim 1 wherein the filter housing includes at least two filter fiber support screens.
Claim 7
Dependent Claim
27 words
The system of claim 5 wherein the screens are fused to form an integral unit adapted to restrain the filter fiber without substantial clogging of the filter.
Claim 8
Dependent Claim
18 words
The system of claim 1 wherein one of the plastic bags includes a red blood cell additive solution.
Claim 9
Dependent Claim
117 words
In a closed multiple blood bag system comprising two flexible plastic bags in closed communication with each other via connecting plastic tubing, the improvement comprising a filter disposed between the two bags and continuous with the connecting tubing, the filter comprising a housing having a volume of less than about 50 cc containing continuous cellulose acetate filtering fiber having a generally Y-shaped cross section and a denier of about 2.2, the filter adapted to permit substantial removal of white blood cells from a mixture of red and white blood blood cells with minimal red blood cell hemolysis when the mixture is passed from one bag to the other through the filter at a relative high flow rate.
Claim 10
Dependent Claim
117 words
In a closed multiple blood bag system comprising two flexible plastic bags in closed communication with each other via connecting plastic tubing, the improvement comprising a filter disposed between the two bags and continuous with the connecting tubing, the filter comprising a housing having a volume of less than about 50 cc containing continuous cellulose acetate filtering fiber having a generally Y-shaped cross section and a denier of about 2.2, the filter adapted to permit substantial removal of white blood cells from a mixture of red and white blood blood cells with minimal red blood cell hemolysis when the mixture is passed from one bag to the other through the filter at a relative high flow rate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-06 | 1992-09-05 | 1993-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-06 | 1996-09-05 | 1997-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-06 | 2000-09-05 | 2001-03-07 | $7700.00 | Window Closed / Lapsed |