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US4806595A
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Method of preparing antithrombogenic medical materials
Assignee: Koken Co Ltd
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Filing: 1986-08-01
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Granted: 1989-02-21
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Expires: 2006-08-01
Abstract
Abstract In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the protamine.
Inventors
- 👤 Yasuharu Noishiki
- 👤 Kazuhiko Kodaira
- 👤 Masayasu Furuse
- 👤 Teruo Miyata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:22
CPC Classifications
C; C08; C08L; C08L5/00; C08L5/10; A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
41 words
A method of preparing an antithrombogenic medical material comprising a heparinized collagen as an antithrombogenic component, which comprises the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing said collagen by fixing heparin to said protamine.
Claim 2
Independent Claim
41 words
A method of preparing an antithrombogenic medical material comprising a heparinized collagen as an antithrombogenic component, which comprises the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing said collagen by fixing heparin to said protamine.
Claim 3
Dependent Claim
25 words
A method according to claim 1, wherein the protamine is at least one member selected from the group consisting of protamine sulfate and protamine hydrochloride.
Claim 4
Dependent Claim
35 words
A method according to claim 1, wherein the polyepoxy compound is at least one member selected from the group consisting of a glycol diglycidyl ether, a polyol polyglycidyl ether, and a dicarboxylic acid diglycidyl ester.
Claim 5
Dependent Claim
15 words
A method according to claim 3, wherein the polyepoxy compound is polyethylene glycol diglycidyl ether.
Claim 6
Dependent Claim
22 words
A method according to claim 1, wherein the antithrombogenic medical material is a composite of a heparinized collagen and a synthetic polymer.
Claim 7
Dependent Claim
40 words
A method according to claim 5, wherein the synthetic polymer material is one member selected from the group consisting of a product prepared by weaving or knitting polyester fibers in the form of a tube, and a plastic molded article.
Claim 8
Dependent Claim
49 words
A method according to claim 1, wherein a substrate is subjected to a coating or impregnating treatment with a solution which contains a collagen and a protamine, and said substrate is subsequently immersed in an aqueous solution of a polyepoxy compound, and then immersed in an aqueous heparin solution.
Claim 9
Dependent Claim
40 words
A method according to claim 1, wherein a substrate is subjected to a coating or impregnating treatment with a solution containing a collagen, a protamine and a polyepoxy compound, and said substrate is further immersed in an aqueous heparin solution.
Claim 10
Dependent Claim
41 words
A method according to claim 1, wherein a substrate is subjected to a coating or impregnating treatment with a solution containing a collagen, a protamine and heparin, and said substrate is further immersed in an aqueous solution of a polyepoxy compound.
Claim 11
Dependent Claim
58 words
A method according to claim 1, wherein a substrate is subjected to a coating or impregnating treatment with a solution containing a collagen, a protamine, a polyepoxy compound and heparin, and said substrate is allowed to stand until the fixation of said protamine to said collagen through said polyepoxy compound is completed, and said substrate is subsequently dried.
Claim 12
Dependent Claim
36 words
A method according to claim 7, wherein at least one mucopolysaccharide selected from the group consisting of hyaluronic acid, chondroitin sulfate and dermatan sulfate is added to said solution which contains a collagen and a protamine.
Claim 13
Dependent Claim
39 words
A method according to claim 8, wherein at least one mucopolysaccharide selected from the group consisting of hyaluronic acid, chondroitin sulfate and dermatan sulfate is added to said solution which contains a collagen, a protamine and a polyepoxy compound.
Claim 14
Dependent Claim
37 words
A method according to claim 9, wherein at least one mucopolysaccharide selected from the group consisting of hyaluronic acid, chondroitin sulfate and ermatan sulfate is added to said solution which contains a collagen, a protamine and heparin.
Claim 15
Dependent Claim
36 words
A method according to claim 7 or 9, wherein at least one mucopolysaccharide selected from the group consisting of hyaluronic acid, chondroitin sulfate and dermatan sulfate is added to said solution which contains a polyepoxy compound.
Claim 16
Dependent Claim
34 words
A method according to claim 7 or 8, wherein at least one mucopolysaccharide selected from the group consisting of hyaluronic acid, chondroitin sulfate and dermatan sulfate is added to said solution which contains heparin.
Claim 17
Dependent Claim
40 words
A method according to claim 10, wherein at least one mucopolysaccharide selected from the group consisting of hyaluronic acid, chondroitin sulfate and dermatan sulfate is added to said solution which contains a collagen, a protamine, a polyepoxy compound and heparin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-02-21 | 1992-08-22 | 1993-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-02-21 | 1996-08-22 | 1997-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-02-21 | 2000-08-22 | 2001-02-21 | $7700.00 | Window Closed / Lapsed |