Patent US4804381A successfully refreshed from Google Patents.
US4804381A
Expired / Lapsed
US
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Artificial vessel
Assignee: Sulzer AG
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Filing: 1987-05-19
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Granted: 1989-02-14
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Expires: 2007-05-19
Abstract
Abstract The arterial vessel is made of a microporous membrane having pores which are filled with a permeable gel or which are closed over by a thin porous layer. A monolayer of endothelial cells is provided on the internal surface for exposure to the blood flow and smooth muscle cells are layered on the outer surface for increasing the viability of the live cells on the membrane and to impart elasticity. A support structure formed of a braided construction of monofilaments of inert material can be provided to limit dilation of the vessel.
Inventors
- 👤 Marko Turina
- 👤 Peter Bittmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:53
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/062; A61L; A61L27/00; A61L27/50; A61L27/507
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
36 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores; a permeable aqueous gel filling said micropores; and a closed monolayer of endothelial cells on an internal surface of said membrane.
Claim 2
Dependent Claim
36 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores; a permeable aqueous gel filling said micropores; and a closed monolayer of endothelial cells on an internal surface of said membrane.
Claim 3
Dependent Claim
24 words
An artificial vessel as set forth in claim 1 wherein at least some of said micropores have a diameter between 10 and 50 μm.
Claim 4
Dependent Claim
27 words
An artificial vessel as set forth in claim 1 which further comprises a layer of smooth elastic fiber-producing muscle cells on an external surface of said membrane.
Claim 5
Dependent Claim
30 words
An artificial vessel as set forth in claim 3 wherein said membrane is tubular and which further comprises a support structure about said membrane for limiting dilation of said membrane.
Claim 6
Dependent Claim
59 words
An artificial vessel comprising a porous tubular membrane of bio-inert synthetic material having completely open micropores; a porous layer on an internal surface of said membrane and having a plurality of pores therein; and a closed monolayer of endothelial cells on said layer, said pores of said layer having a size approximately equal to one of said endothelial cells.
Claim 7
Dependent Claim
59 words
An artificial vessel comprising a porous tubular membrane of bio-inert synthetic material having completely open micropores; a porous layer on an internal surface of said membrane and having a plurality of pores therein; and a closed monolayer of endothelial cells on said layer, said pores of said layer having a size approximately equal to one of said endothelial cells.
Claim 8
Dependent Claim
24 words
An artificial vessel as set forth in claim 5 wherein at least some of said micropores have a diameter between 10 and 50 μm.
Claim 9
Dependent Claim
27 words
An artificial vessel as set forth in claim 5 which further comprises a layer of smooth elastic fiber-producing muscle cells on an external surface of said membrane.
Claim 10
Dependent Claim
24 words
An artificial vessel as set forth in claim 7 which further comprises a support structure about said membrane for limiting dilation of said membrane.
Claim 11
Dependent Claim
63 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores; means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; a closed monolayer of endothelial cells on said internal surface of said membrane; and a layer of smooth elastic fiber-producing muscle cells on an external surface of said membrane.
Claim 12
Dependent Claim
63 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores; means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; a closed monolayer of endothelial cells on said internal surface of said membrane; and a layer of smooth elastic fiber-producing muscle cells on an external surface of said membrane.
Claim 13
Dependent Claim
61 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material made of polyurethane of a thickness of from 0.1 to 1 millimeters and having completely open micropores; means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and a closed monolayer of endothelial cells on said internal surface of said membrane.
Claim 14
Dependent Claim
61 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material made of polyurethane of a thickness of from 0.1 to 1 millimeters and having completely open micropores; means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and a closed monolayer of endothelial cells on said internal surface of said membrane.
Claim 15
Dependent Claim
66 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores; an aqueous gel filling said micropores and being permeable to molecules of a molecular weight up to 100,000 Dalton to smooth an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and a closed monolayer of endothelial cells on said internal surface of said membrane.
Claim 16
Dependent Claim
66 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores; an aqueous gel filling said micropores and being permeable to molecules of a molecular weight up to 100,000 Dalton to smooth an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and a closed monolayer of endothelial cells on said internal surface of said membrane.
Claim 17
Dependent Claim
64 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores; a porous layer for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and a closed monolayer of endothelial cells on said porous layer with said porous layer having pores of a diameter equal to the dimensions of an endothelial cell.
Claim 18
Dependent Claim
64 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores; a porous layer for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and a closed monolayer of endothelial cells on said porous layer with said porous layer having pores of a diameter equal to the dimensions of an endothelial cell.
Claim 19
Dependent Claim
62 words
An artificial vessel comprising a porous tubular membrane of bio-inert synthetic material having completely open micropores; means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; a closed monolayer of endothelial cells on said internal surface of said membrane, and a braided support structure about said membrane for limiting dilation of said membrane.
Claim 20
Dependent Claim
62 words
An artificial vessel comprising a porous tubular membrane of bio-inert synthetic material having completely open micropores; means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; a closed monolayer of endothelial cells on said internal surface of said membrane, and a braided support structure about said membrane for limiting dilation of said membrane.
Claim 21
Dependent Claim
62 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores, at least some of said micorpores having a diameter between 10 and 50 μm; means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and a closed monolayer of endothelial cells on said internal surface of said membrane.
Claim 22
Dependent Claim
62 words
An artificial vessel comprising a porous membrane of bio-inert synthetic material having completely open micropores, at least some of said micorpores having a diameter between 10 and 50 μm; means for smoothing an internal surface of said membrane while at least partially maintaining the permeability of said membrane; and a closed monolayer of endothelial cells on said internal surface of said membrane.
Claim 23
Dependent Claim
18 words
An artificial vessel as set forth in claim 14 wherein said micropores have a diameter of 30 μm.
Claim 24
Dependent Claim
28 words
An artificial vessel as set forth in claim 13 wherein said support structure consists of a knitted textile having a stitch width of from 0.2 to 2 millimeters.
Claim 25
Dependent Claim
36 words
An artificial vessel as set forth in claim 16 wherein said membrane has a linear elasticity of from 0.03 to 0.1% per mm Hg pressure increase at an internal pressure of 80 to 150 mm Hg.
Claim 26
Dependent Claim
32 words
An artificial vessel as set forth in claim 16 wherein said braided support structure consists of a braiding of individual spirally arranged filaments of polyester threads of 10 to 40 μm diameter.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-02-14 | 1992-08-15 | 1993-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-02-14 | 1996-08-15 | 1997-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-02-14 | 2000-08-15 | 2001-02-14 | $7700.00 | Window Closed / Lapsed |