Controlled release device for an active substance

Claim 3

A device of claim 1 wherein the truncated cone has a convex base.

Claim 4

A device of claim 1 wherein the ratio of the diameters of the top to the base of the truncated cone is in the range of 1:2 to 1:4, and the ratio of the height to the diameter of the base is in the range of 1:1 to 1:4.

Claim 5

A device of claim 3 wherein the truncated cone has a convex base.

Claim 6

A device of claim 2 wherein the truncated cone has a concave side.

Claim 7

A device of claim 4 wherein the truncated cone has a concave side.

Claim 8

A device of claim 1 wherein the substance is biologically active.

Claim 9

A device of claim 7 wherein the activity is to prevent or reduce odors in or emanating from the fluid medium.

Claim 10

A device of claim 7 wherein the substance has germicidal activity.

Claim 11

A device of claim 7 wherein the substance has pharmaceutical activity.

Claim 12

A bolus for oral administration into the reticulum or rumen of a ruminant mammal, said bolus being retained in said rumen or reticulum and releasing one or more active agents into the environment of said rumen or reticulum at a substantially constant rate over a prolonged period of time, which comprises said active agent or agents homogeneously disposed in a matrix and contained substantially in the shape of one or a plurality of truncated cones by means of an impermeable wall on the base and side of said truncated cone or cones.

Claim 13

A bolus for oral administration into the reticulum or rumen of a ruminant mammal, said bolus being retained in said rumen or reticulum and releasing one or more active agents into the environment of said rumen or reticulum at a substantially constant rate over a prolonged period of time, which comprises said active agent or agents homogeneously disposed in a matrix and contained substantially in the shape of one or a plurality of truncated cones by means of an impermeable wall on the base and side of said truncated cone or cones.

Claim 14

A bolus of claim 11 having said active agent contained in a plurality of truncated cone shaped cavities in a plurality of flat cylinders or discs mounted in a carrier of elongated cylindrical shape and spaced to permit of access of the top of said truncated cones to said environment of the rumen or reticulum, said carrier having an attached flexible and resilient flap capable of constrainment in rolled configuration around said elongated cylinder by a constraining means which releases said flap once in the environment of the reticulum or rumen.

Claim 15

A bolus of claim 12 wherein the active agent is morantel or a pharmaceutically acceptable salt thereof in a polymer matrix.

Claim 16

A tablet for oral administration to a mammal which releases a pharmaceutically active substance into the fluid of the gastrointestinal tract if said mammal at a substantially constant rate over an appreciable time interval which comprises said substance homogeneously disposed, with or without one or more pharmaceutically-acceptable diluents, and contained, substantially in the shape of a truncated cone, by means of an impermeable coating or wall on the base and side of said truncated cone.

Claim 17

A tablet for oral administration to a mammal which releases a pharmaceutically active substance into the fluid of the gastrointestinal tract if said mammal at a substantially constant rate over an appreciable time interval which comprises said substance homogeneously disposed, with or without one or more pharmaceutically-acceptable diluents, and contained, substantially in the shape of a truncated cone, by means of an impermeable coating or wall on the base and side of said truncated cone.

Claim 18

A tablet of claim 14 wherein the truncated cone has a convex base.

Claim 19

A tablet of claim 14 wherein the ratio of the diameters of top to the bottom of the truncated cone is in the range of 1:2 to 1:4, and the ratio of the height to the diameter of the base is in the range of 1:1 to 1:4.

Claim 20

A tablet claim 16 wherein the truncated cone has a convex base.

Claim 21

A tablet of claim 15 wherein the truncated cone has a concave side.

Claim 22

A tablet of claim 17 wherein the truncated cone has a concave side.

Claim 23

A tablet of claim 14 contained by means of coating.

Claim 24

A tablet of claim 17 contained by means of coating.

Claim 25

A tablet of claim 21 wherein the substance is an antihypertensive.

Claim 26

A tablet of claim 22 wherein the substance is prazosin.

Claim 27

A tablet of claim 22 wherein the substance is trimazosin.

Claim 28

A tablet of claim 22 wherein the substance is doxazosin.

Claim 29

A tablet of claim 21 wherein the substance is an antianxiety agent.

Claim 30

A tablet of claim 26 wherein the substance is hydroxyzine.

Claim 31

A tablet of claim 26 wherein the substance is sertraline.

Claim 32

A tablet of claim 21 wherein the substance is a bronchodilator.

Claim 33

A tablet of claim 29 wherein the substance is pirbuterol.

Claim 34

A tablet of claim 21 wherein the substance is a blood-glucose lowering agent.

Claim 35

A tablet of claim 31 wherein the substance is glipizide.

Claim 36

A single-station or multistation tablet press for use in the manufacture of tablets substantially in the shape of a truncated cone which, at each station, comprises (a) a conventional, substantially round and flat or convex lower punch; (b) a conventional, substantially round die; and (c) a corresponding upper punch having a cavity which is substantially in the shape of a truncated cone.

Claim 37

A single-station or multistation tablet press for use in the manufacture of tablets substantially in the shape of a truncated cone which, at each station, comprises (a) a conventional, substantially round and flat or convex lower punch; (b) a conventional, substantially round die; and (c) a corresponding upper punch having a cavity which is substantially in the shape of a truncated cone.

Claim 38

A tablet press of claim 33 wherein the lower punch is convex.

Claim 39

A tablet press of claim 34 wherein the side of the cone shaped cavity is concave in shape.

Claim 40

A tablet press of claim 34 wherein the ratio of the diameters of the top and the base of said truncated cone is in the range of 1:2 to 1:4 and the ratio of the height to the diameter of the base is in the range of 1:1 to 1:4.

Claim 43

A process for the preparation of a tablet of claim 20 which comprises the steps of: (a) forming uncoated tablets substantially in the shape of a truncated cone in a single-station or multistation tablet press comprising a conventional, substantially round and flat or convex lower punch; a conventional, corresponding substantially round central die; and a corresponding upper punch having a cavity which is substantially in the shape of a truncated cone; (b) fully coating said uncoated tablets with an impermeable coating by conventional means; (c) removing the coating from the smaller diameter end of the fully coated tablets by means of apparatus comprising a moving horizontal plate having perforations of a shape and size to seat said tablets with the smaller end below the plane of the plate; a means for seating said fully coated tablets in said perforations; a stationary support means above said moving plate to hold said tablets in place; a stationary grinding means below the plane of said plate spaced so as to remove the coating from the smaller diameter end of the fully coated tablets; and a means for ejecting the finished tablets.

Claim 44

A process of claim 38 wherein in step (a) the lower punch is convex.