Patent US4793825A successfully refreshed from Google Patents.
US4793825A
Expired / Lapsed
US
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Active silicon implant devices
Assignee: UK Secretary of State for Defence
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Filing: 1985-09-11
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Granted: 1988-12-27
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Expires: 2005-09-11
Abstract
Abstract A medical implant for injecting into the vascular system of animals comprises a device less than 500 mu m in size carrying signal processing means for providing an output in response to an input signal. The input may be acoustic, electromagnetic, temperature, pH value, or chemical. The output may be acoustic, electromagnetic, or chemical. Large numbers, e.g., 108, of the implant devices may be mixed into a saline solution and injected into a blood vessel where they are carried around the vascular system, or the devices may be mixed with a gas and inhaled. The amount of circulation depends on the device size. For the larger device e.g., above 7 mu m to around 250 mu m, circulation will be short lived. Smaller sized e.g., <3 mu m devices will circulate for a considerable time. Anti-bodies may be coated onto the devices to cause them to adhere to target areas such as tumors. In one device a chemical is released when illuminated externally by an acoustic beam. In another device a chemical is released when the pH of surrounding blood changes to a given level. Power to operate the device may be by an integral battery.
Inventors
- 👤 John D. Benjamin
- 👤 Adrian L. Mears
- 👤 John C. White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:26
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/07; A61M; A61M37/00; H; H10; H10D; H10D99/00
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
79 words
An intravascular implant comprising a plurality of microelectronic devices each encapsulating a pharmaceutical compound or composition and each having a maximum dimension of less than 500 μm and adapted to pass through a body along blood vessels in large numbers, each device incorporating signal processing means for providing an output in response to an input signal, said output of said signal processing means causing rupture of said device and release of said pharmaceutical compound or composition into said body.
Claim 2
Dependent Claim
79 words
An intravascular implant comprising a plurality of microelectronic devices each encapsulating a pharmaceutical compound or composition and each having a maximum dimension of less than 500 μm and adapted to pass through a body along blood vessels in large numbers, each device incorporating signal processing means for providing an output in response to an input signal, said output of said signal processing means causing rupture of said device and release of said pharmaceutical compound or composition into said body.
Claim 3
Dependent Claim
16 words
The implant of claim 1 wherein said devices are less then 7 μm in maximum dimension.
Claim 4
Dependent Claim
26 words
The implant of claim 2 wherein each device includes piezo electric material and rectifying means cooperating with said piezo electric material for generating an electric signal.
Claim 5
Dependent Claim
16 words
The implant of claim 1 wherein said devices are less than 3 μm in maximum dimension.
Claim 6
Dependent Claim
11 words
The implant of claim 1 wherein said input signal is acoustic.
Claim 7
Dependent Claim
11 words
The implant of claim 1 wherein said input signal is electromagnetic.
Claim 8
Dependent Claim
13 words
The implant of claim 1 wherein said input signal is representative of temperature.
Claim 9
Dependent Claim
29 words
The implant of claim 7 wherein said signal processing means includes a diode having electrical characteristics which vary with temperature and thereby provide said input signal representative of temperature.
Claim 10
Dependent Claim
14 words
The implant of claim 1 wherein said input signal is representative of pH value.
Claim 11
Dependent Claim
30 words
The implant of claim 9 wherein said signal processing means includes a chemically sensitive field effect transistor for measuring pH values thereby providing said input signal representative of pH value.
Claim 12
Dependent Claim
11 words
The implant of claim 1 wherein the input signal is chemical.
Claim 13
Dependent Claim
10 words
The implant of claim 1 wherein the output is acoustic.
Claim 14
Dependent Claim
10 words
The implant of claim 1 wherein the output is electromagnetic.
Claim 15
Dependent Claim
10 words
The implant of claim 1 wherein the output is chemical.
Claim 16
Dependent Claim
11 words
The implant of claim 1 wherein each device includes a battery.
Claim 17
Dependent Claim
13 words
The implant of claim 1 wherein each device further comprises an antibody coating.
Claim 18
Dependent Claim
94 words
A pharmaceutical preparation comprising a plurality of semiconductor devices in a pharmaceutically acceptable carrier or diluent, each device having a maximum dimension less than 500 μm and encapsulating a pharmaceutical compound or composition and adapted to pass along blood vessels in large numbers, said devices each including signal processing means for providing an output in response to an input signal, each said device having a frangible part which is capable of rupturing to release said pharmaceutical compound or compositon from each said device on receipt of said output from each said signal processing means.
Claim 19
Dependent Claim
94 words
A pharmaceutical preparation comprising a plurality of semiconductor devices in a pharmaceutically acceptable carrier or diluent, each device having a maximum dimension less than 500 μm and encapsulating a pharmaceutical compound or composition and adapted to pass along blood vessels in large numbers, said devices each including signal processing means for providing an output in response to an input signal, each said device having a frangible part which is capable of rupturing to release said pharmaceutical compound or compositon from each said device on receipt of said output from each said signal processing means.
Claim 20
Dependent Claim
24 words
The preparation of claim 17 wherein each device comprises a chemically sensitive field effect transistor for measuring pH values to provide said input signal.
Claim 21
Dependent Claim
21 words
The preparation of claim 17 wherein said signal processing means includes a diode for measuring temperature to provide said input signal.
Claim 22
Independent Claim
118 words
A method of treating the animal or human body comprising administering a pharmaceutical preparation into the vascular system in an amount effective to treat the body, said pharmaceutical preparation comprising a plurality of semiconductor devices in a pharmaceutically acceptable carrier or diluent, each device having a maximum diameter less than 500 μm and encapsulating a pharmaceutical compound or composition and adapted to pass along blood vessels in large numbers, each of said devices including signal processing means for providing an output in response to an input signal, each of said devices having a frangible part which is capable of rupturing to release said pharmaceutical compound or composition on receipt of said output from each said signal processing means.
Claim 23
Independent Claim
118 words
A method of treating the animal or human body comprising administering a pharmaceutical preparation into the vascular system in an amount effective to treat the body, said pharmaceutical preparation comprising a plurality of semiconductor devices in a pharmaceutically acceptable carrier or diluent, each device having a maximum diameter less than 500 μm and encapsulating a pharmaceutical compound or composition and adapted to pass along blood vessels in large numbers, each of said devices including signal processing means for providing an output in response to an input signal, each of said devices having a frangible part which is capable of rupturing to release said pharmaceutical compound or composition on receipt of said output from each said signal processing means.
Claim 24
Dependent Claim
45 words
The method of claim 20 wherein the body is selectively subject to electromagnetic, or ionizing radiation, or acoustic energy to provide said input signal to said signal processing means to obtain release of said pharmaceutical compound or composition in a selected part of said body.
Claim 25
Independent Claim
100 words
A method of detecting a body function in an animal or human body comprising the steps of: inserting or inhaling into a body part a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent containing a plurality of intravascular devices, each device having a maximum dimension less than 500 microns and adapted to pass along blood vessels, each device including signal processing means for providing an output in response to an input signal; providing an input signal to each said intravascular device; and obtaining an output response from at least a plural subset from among the plurality of intravascular devices.
Claim 26
Independent Claim
100 words
A method of detecting a body function in an animal or human body comprising the steps of: inserting or inhaling into a body part a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent containing a plurality of intravascular devices, each device having a maximum dimension less than 500 microns and adapted to pass along blood vessels, each device including signal processing means for providing an output in response to an input signal; providing an input signal to each said intravascular device; and obtaining an output response from at least a plural subset from among the plurality of intravascular devices.
Claim 27
Dependent Claim
25 words
The method of claim 22 wherein the body is selectively subjected to an electromagnetic or ionizing radiation, or acoustic energy to provide said input signal.
Claim 28
Dependent Claim
23 words
The method of claim 22 wherein said intravascular devices are subject to a temperature, pH or chemical range to provide said input signal.
Claim 29
Dependent Claim
13 words
The method of claim 22 wherein said output is acoustic, electromagnetic, or chemical.
Claim 30
Dependent Claim
29 words
The method of claim 22 wherein said pharmaceutically acceptable carrier is a volatile liquid wherein said step of inhaling includes the step of administering by inhalation as a gas.
Claim 31
Independent Claim
92 words
A method of delivering a drug substance to a predetermined body site of an animal or a human body comprising the steps of: administering to said animal or human a pharmaceutical composition of a pharmaceutical carrier or diluent containing an intravascular microdisc device having a maximum dimension less than 500 microns adapted to pass along blood vessels, said device including said drug substance, and signal processing means for releasing said drug substance in response to an input signal; and providing said input signal thereby releasing said drug substance for said intravascular device.
Claim 32
Independent Claim
92 words
A method of delivering a drug substance to a predetermined body site of an animal or a human body comprising the steps of: administering to said animal or human a pharmaceutical composition of a pharmaceutical carrier or diluent containing an intravascular microdisc device having a maximum dimension less than 500 microns adapted to pass along blood vessels, said device including said drug substance, and signal processing means for releasing said drug substance in response to an input signal; and providing said input signal thereby releasing said drug substance for said intravascular device.
Claim 33
Dependent Claim
18 words
The delivery method of claim 27 wherein said input signal is electromagnetic, or ionizing radiation, or acoustic energy.
References Cited (Backward Citations)
DE109081C
Cited
AU356821A
Cited
AU340038A
Cited
US3672352A
Cited
US3659615A
Cited
US4351337A
Cited
US3962412A
Cited
US4003379A
Cited
US4115536A
Cited
GB1545271A
Cited
GB1551792A
Cited
DE2548838A1
Cited
GB1528265A
Cited
EP0000667A1
Cited
DE2941363A1
Cited
US4310505A
Cited
EP0042249A2
Cited
US4507115A
Cited
WO1983001738A1
Cited
US4494950A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-27 | 1992-06-27 | 1992-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-27 | 1996-06-27 | 1996-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-27 | 2000-06-27 | 2000-12-27 | $7700.00 | Window Closed / Lapsed |