Patent US4781889A successfully refreshed from Google Patents.
US4781889A
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Hollow fiber membrane type artificial lung
Assignee: Terumo Corp
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Filing: 1987-08-03
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Granted: 1988-11-01
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Expires: 2007-08-03
Abstract
Abstract A hollow fiber membrane type artificial lung and a method for the manufacture thereof. The artificial lung comprises a housing, a hollow fiber bundle positioned in the housing and formed of a multiplicity of gas-exchange hollow fiber membranes, a first fluid chamber defined by the external surfaces of the hollow fiber membranes and the internal surface of the housing, a first fluid inlet and a first fluid outlet both communicating with the first fluid chamber, partitions supporting in place the opposite ends of the hollow fibers and provided at the inner face of the housing, and a second fluid inlet and a second fluid outlet allowed to communicate with the empty spaces inside the hollow fiber membranes, which artificial lung is characterized by the fact that the hollow fiber membranes are produced by causing porous hollow fiber substrates which have through micropores distributed in the walls thereof to be treated with silicone oil so that the silicone oil will block up said micropores without forming a silicone oil layer on the internal surfaces of the walls of the porous hollow fiber substrates.
Inventors
- 👤 Hiromichi Fukasawa
- 👤 Yoshiro Katsura
- 👤 Kazuhiko Hagiwara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:48
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; B01D61/00; B01D61/38; B01D63/00; B01D63/02; B01D63/021; B01D63/0232; B01D2323/00; B01D2323/28; B01D2323/283; Y; Y10; Y10S; Y10S128/00; Y10S128/03; Y10S261/00; Y10S261/28
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
232 words
A hollow fiber membrane type artificial lung comprising: a housing; a hollow fiber bundle positioned in said housing and comprising a multiplicity of gas-exchange hollow fiber membranes; a first fluid chamber defined by the external surfaces of said hollow fiber membranes and the internal surface of said housing; a first fluid inlet and a first fluid outlet both communicating with said first fluid chamber; partitions supporting in place opposite ends of said hollow fiber membranes and provided at an inner face of said housing; and a second fluid inlet and a second fluid outlet communicating with empty spaces inside said hollow fiber membranes; said hollow fiber membranes comprising porous hollow fiber substrates which have been impregnated with silicone oil and have through micropores distributed in the walls thereof; said porous hollow fiber substrates being hollow fiber membranes having an inside diameter in the range of 100 to 1000 μm, a wall thickness in the range of 5 to 100 μm, a porosity in the range of 40 to 80% and containing in the walls thereof said micropores of a diameter in the range of 100 Å to 5 μm; and said silicone oil having a viscosity in the range of 50 to 3000 mPa.s, said silicone oil blocking said micropores and said hollow fiber substrates being free of a silicone oil layer on the internal and external surfaces of the walls thereof.
Claim 2
Dependent Claim
232 words
A hollow fiber membrane type artificial lung comprising: a housing; a hollow fiber bundle positioned in said housing and comprising a multiplicity of gas-exchange hollow fiber membranes; a first fluid chamber defined by the external surfaces of said hollow fiber membranes and the internal surface of said housing; a first fluid inlet and a first fluid outlet both communicating with said first fluid chamber; partitions supporting in place opposite ends of said hollow fiber membranes and provided at an inner face of said housing; and a second fluid inlet and a second fluid outlet communicating with empty spaces inside said hollow fiber membranes; said hollow fiber membranes comprising porous hollow fiber substrates which have been impregnated with silicone oil and have through micropores distributed in the walls thereof; said porous hollow fiber substrates being hollow fiber membranes having an inside diameter in the range of 100 to 1000 μm, a wall thickness in the range of 5 to 100 μm, a porosity in the range of 40 to 80% and containing in the walls thereof said micropores of a diameter in the range of 100 Å to 5 μm; and said silicone oil having a viscosity in the range of 50 to 3000 mPa.s, said silicone oil blocking said micropores and said hollow fiber substrates being free of a silicone oil layer on the internal and external surfaces of the walls thereof.
Claim 3
Dependent Claim
131 words
The hollow fiber membrane type artificial lung according to claim 1, wherein said first fluid inlet is coupled to a source of oxygen gas, said second fluid inlet is coupled to a source of blood, said hollow fiber bundle being adapted to pass blood therethrough with a flow volume of blood of 1 l/min. per 1 m 2 of the hollow fiber membrane area and a flow volume of carbon dioxide of at least 40 ml/min. per 1 m 2 of the hollow fiber membrane area when the flow amount of oxygen gas is 3 l/min. per 1 m 2 of the hollow fiber membrane, whereby there is no leakage of blood plasma when the blood is cycled in the hollow fiber membrane for a period of up to 12 hours.
Claim 4
Dependent Claim
40 words
The hollow fiber membrane type artificial lung according to claim 1, wherein said silicone oil is selected from the group consisting of dimethyl silicone oil, methylphenyl silicone oil, methylchlorophenyl silicone oil, branched dimethyl silicone oil and methyl hydrogen silicone oil.
Claim 5
Dependent Claim
22 words
The hollow fiber membrane type artificial lung according to claim 1, wherein said porous hollow fiber substrates are made of a polyolefin.
Claim 6
Dependent Claim
16 words
The hollow fiber membrane type artificial lung according to claim 4, wherein said polyolefin is polypropylene.
Claim 7
Dependent Claim
60 words
The hollow fiber membrane type artificial lung according to claim 1, wherein said hollow fiber membranes have an inside diameter in the range of 100 to 300 μm and a wall thickness in the range of 5 Å to 80 μm and containing in the walls thereof micropores having a diameter in the range of 100 Å to 1 μm.
Claim 8
Dependent Claim
23 words
The hollow fiber membrane type artificial lung according to claim 6, wherein said silicone oil is dimethyl silicone oil or methylphenyl silicone oil.
Claim 9
Dependent Claim
22 words
The hollow fiber membrane type artificial lung according to claim 6, wherein said porous hollow fiber substrates are made of a polyolefin.
Claim 10
Dependent Claim
16 words
The hollow fiber membrane type artificial lung according to claim 8 wherein said polyolefin is polypropylene.
Claim 11
Dependent Claim
19 words
The hollow fiber membrane type artificial lung according to claim 9, wherein said silicone oil is dimethyl silicone oil.
Claim 12
Dependent Claim
252 words
A hollow fiber membrane type artificial lung comprising: a housing; a hollow fiber bundle positioned in said housing and comprising a multiplicity of gas-exchange hollow fiber membranes; a first fluid chamber defined by the external surfaces of said hollow fiber membranes and the internal surface of said housing; a first fluid inlet and a first fluid outlet both communicating with said first fluid chamber; partitions supporting in place opposite ends of said hollow fiber membranes and provided at an inner face of said housing; and a second fluid inlet and a second fluid outlet communicating with empty spaces inside said hollow fiber membranes; said hollow fiber membranes being porous hollow fiber substrates which have through micropores distributed in the walls thereof, said micropores being closed with a silicone oil impregnated into said hollow fiber substrates to fill the micropores thereof, and being substantially removed from internal surfaces of said walls of said porous hollow fibers by flowing a mixture of a solvent for said silicone oil and a non-solvent for said silicone oil into said hollow fiber substrates whereby said internal and external wall surfaces are substantially free of silicone oil; and said porous hollow fiber substrates being hollow fiber membranes having an inside diameter in the range of 100 to 1000 μm, a wall thickness in the range of 5 to 80 μm, porosity in the range of 40 to 80% and containing in the walls thereof said micropores of a diameter in the range of 100 Å to 5 μm.
Claim 13
Dependent Claim
252 words
A hollow fiber membrane type artificial lung comprising: a housing; a hollow fiber bundle positioned in said housing and comprising a multiplicity of gas-exchange hollow fiber membranes; a first fluid chamber defined by the external surfaces of said hollow fiber membranes and the internal surface of said housing; a first fluid inlet and a first fluid outlet both communicating with said first fluid chamber; partitions supporting in place opposite ends of said hollow fiber membranes and provided at an inner face of said housing; and a second fluid inlet and a second fluid outlet communicating with empty spaces inside said hollow fiber membranes; said hollow fiber membranes being porous hollow fiber substrates which have through micropores distributed in the walls thereof, said micropores being closed with a silicone oil impregnated into said hollow fiber substrates to fill the micropores thereof, and being substantially removed from internal surfaces of said walls of said porous hollow fibers by flowing a mixture of a solvent for said silicone oil and a non-solvent for said silicone oil into said hollow fiber substrates whereby said internal and external wall surfaces are substantially free of silicone oil; and said porous hollow fiber substrates being hollow fiber membranes having an inside diameter in the range of 100 to 1000 μm, a wall thickness in the range of 5 to 80 μm, porosity in the range of 40 to 80% and containing in the walls thereof said micropores of a diameter in the range of 100 Å to 5 μm.
Claim 14
Dependent Claim
40 words
The hollow fiber membrane type artificial lung according to claim 11, wherein said silicone oil is selected from the group consisting of dimethyl silicone oil, methylphenyl silicone oil, methylchlorophenyl silicone oil, branched dimethyl silicone oil and methyl hydrogen silicone oil.
Claim 15
Dependent Claim
22 words
The hollow fiber membrane type artificial lung according to claim 12, wherein said porous hollow fiber substrates are made of a polyolefin.
Claim 16
Dependent Claim
16 words
The hollow fiber membrane type artificial lung according to claim 13, wherein said polyolefin is polypropylene.
Claim 17
Dependent Claim
19 words
The hollow fiber membrane type artificial lung according to claim 14, wherein said silicone oil is dimethyl silicone oil.
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