US4780322A
Expired / Lapsed
US
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Method of producing slow-release pharmaceutical forms
Assignee: Cortial SA
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Filing: 1986-01-21
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Granted: 1988-10-25
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Expires: 2006-01-21
Abstract
Abstract The invention relates to a novel method of producing slow-release pharmaceutical forms administered per os, by simultaneously employing two resins having anionic character, the proportions of said resins being variable. By varying the ratio of the amounts of active principles on the respective two resins, it is possible to modify the release kinetics of active principle; and by independently varying the amount of carboxylic resin it is possible to produce stabile pharmaceutical preparations which are in liquid, semi-liquid, or solid form.
Inventors
- 👤 Rosa Martani
- 👤 Elisabeth Le Huede
- 👤 Jeanne Dumas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:00
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/32; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/585
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
60 words
A method for producing a slow-release pharmaceutical preparation, said method consisting essentially of combining two resins having anionic character with an active cationic principle, wherein the first resin is a sulfonate resin and the second resin is a carboxylic resin comprising a cationic exchange resin which has free carboxylic acid groups to which a basic reacting drug can be absorbed.
Claim 2
Independent Claim
60 words
A method for producing a slow-release pharmaceutical preparation, said method consisting essentially of combining two resins having anionic character with an active cationic principle, wherein the first resin is a sulfonate resin and the second resin is a carboxylic resin comprising a cationic exchange resin which has free carboxylic acid groups to which a basic reacting drug can be absorbed.
Claim 3
Dependent Claim
33 words
The method of claim 1, said method comprising varying the relative amounts of the said active principle fixed on the two said resins to adjust the release kinetics of the slow-release pharamceutical preparation.
Claim 4
Dependent Claim
53 words
The method of claim 1, said method comprising independently varying the amount of the said carboxylic resin in the said preparation to produce a stable slow-release pharmaceutical preparation in liquid, semi-liquid, gel, powder or compressed tablet form, wherein the release kinetics of the said active principle are not influenced by variations in pH.
Claim 5
Independent Claim
47 words
A method for producing a slow-release pharmaceutical preparation consisting essentially of combining one or more cationic drugs with two anionic resins, wherein the said first resin is a polystyrene resin containing sulfonate groups, and the second resin is a carboxyvinyl polymer resin or a carboxymethyl cellulose resin.
Claim 6
Independent Claim
47 words
A method for producing a slow-release pharmaceutical preparation consisting essentially of combining one or more cationic drugs with two anionic resins, wherein the said first resin is a polystyrene resin containing sulfonate groups, and the second resin is a carboxyvinyl polymer resin or a carboxymethyl cellulose resin.
Claim 7
Dependent Claim
32 words
A slow-release pharmaceutical preparation, consisting essentially of a sulfonate resin and a carboxylic resin in combination with an active principle, wherein the said active principle has a cationic character and a short-half-life.
Claim 8
Dependent Claim
32 words
A slow-release pharmaceutical preparation, consisting essentially of a sulfonate resin and a carboxylic resin in combination with an active principle, wherein the said active principle has a cationic character and a short-half-life.
Claim 9
Dependent Claim
36 words
The slow-release pharamceutical preparation of claim 5, wherein the said active principle is at least one member selected from the group consisting of metoclopramide, codeine, dextromethorphan, morphine, morphine derivatives exclusive of their salts and salts thereof.
Claim 10
Dependent Claim
18 words
The slow-release pharmaceutical preparation of claim 6, wherein the said active principle comprises metoclopramide or a salt thereof.
Claim 11
Dependent Claim
18 words
The slow-release pharamceutical preparation of claim 6, wherein the said active principle comprises codeine or a salt thereof.
Claim 12
Dependent Claim
18 words
The slow-release pharmaceutical preparation of claim 6, wherein the said active principle comprises dextromethorphan or a salt thereof.
Claim 13
Dependent Claim
18 words
The slow-release pharmaceutical preparation of claim 6, wherein the said active principle comprises morphine or a morphine derivative.
Claim 14
Dependent Claim
18 words
The slow-release preparation of claim 5, wherein the said sulfonate resin comprises a crosslinked polymer containing sulfonate groups.
Claim 15
Dependent Claim
17 words
The slow-release preparation of claim 11, wherein the crosslinking agent of the said crosslinked polymer is divinylbenzene.
Claim 16
Dependent Claim
35 words
The slow-release prepartion of claim 11, wherein the degree of crosslinking is in the neighborhood of 7-9%, and the said crosslinked polymer is in the form of particles of less than 200 microns in size.
Claim 17
Dependent Claim
25 words
The slow-release preparation of claim 11, wherein form 30 to 70 wt. % of the said active principle is fixed to the said sulfonate resin.
Claim 18
Dependent Claim
16 words
The slow-release preparation of claim 5, wherein the said carboxylic resin is a carboxymethyl cellulose resin.
Claim 19
Dependent Claim
29 words
The slow-release preparation of claim 5, wherein the said carboxylic resin is a high molecular weight crosslinked polymer of acrylic acid, containing 56 to 68 wt. % carboxylate groups.
Claim 20
Dependent Claim
30 words
The slow-release pharamceutical preparation of claim 5, wherein the said preparation is in the form of a liquid, a semi-liquid, a gel, a compressed tablet, a powder or a packet.
Claim 21
Dependent Claim
24 words
The slow-release pharmaceutical preparation of claim 5, wherein the rate of delivery of the said active principle is not influenced by variations in pH.
Claim 22
Dependent Claim
41 words
A slow-release pharmaceutical preparation consisting essentially of one or more cationic drugs with two anionic resins, wherein the first resin is a polystyrene resin containing sulfonate groups, and the second resin is a carboxyvinyl polymer resin or a carboxymethyl cellulose resin.
Claim 23
Dependent Claim
41 words
A slow-release pharmaceutical preparation consisting essentially of one or more cationic drugs with two anionic resins, wherein the first resin is a polystyrene resin containing sulfonate groups, and the second resin is a carboxyvinyl polymer resin or a carboxymethyl cellulose resin.
Claim 24
Independent Claim
34 words
A method for administering a pharmaceutically active principle, consisting essentially of: (i) combining the said pharamceutically active principle with a sulfonate resin and a carboxylic resin, and (ii) administering the combination of step (i).
Claim 25
Independent Claim
34 words
A method for administering a pharmaceutically active principle, consisting essentially of: (i) combining the said pharamceutically active principle with a sulfonate resin and a carboxylic resin, and (ii) administering the combination of step (i).
Claim 26
Dependent Claim
31 words
The method of claim 20, comprising adjusting the kinetics of administration of the said pharmaceutically active principle by varying the relative amounts of active principle fixed on the two resins respectively.
Claim 27
Dependent Claim
26 words
The method of claim 20, comprising fixing from 30 to 70 wt. % of the said active principle to the said sulfonate resin, prior to adminstration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-25 | 1992-04-25 | 1992-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-25 | 1996-04-25 | 1996-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-25 | 2000-04-25 | 2000-10-25 | $7700.00 | Window Closed / Lapsed |