Patent US4775361A successfully refreshed from Google Patents.
US4775361A
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Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
Assignee: General Hospital Corp
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Filing: 1986-04-10
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Granted: 1988-10-04
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Expires: 2006-04-10
Abstract
Abstract A method of administering a therapeutic substance to a human patient, the method having the steps of ablating the stratum corneum of a region of the skin of the patient using pulsed laser light of wavelength, pulse length, pulse energy, pulse number, and pulse repetition rate sufficient to ablate the stratum corneum without significantly damaging the underlying epidermis, and applying the therapeutic substance to the region of ablation.
Inventors
- 👤 Steven L. Jacques
- 👤 Daniel J. McAuliffe
- 👤 Irvin H. Blank
- 👤 John A. Parrish
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:16
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0092; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/203; A61K; A61K41/00; A61K41/0047; A61B17/00; A61B2017/00743; A61B2017/00747; A61B2017/00761; A61B2017/00765; A61B2018/00315; A61B2018/00452; A61B5/00; A61B5/15; A61B5/150007; A61B5/150015; A61B5/150022; A61B5/151; A61B5/15134; A61B5/15136
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
58 words
A method of facilitating percutaneous transport by overcoming the barrier function of the stratum corneum, said method comprising ablating the stratum corneum of a region of the skin of said patient using pulsed laser light of wavelength, pulse length, pulse energy, pulse number, and pulse repetition rate sufficient to ablate said corneum without significantly damaging the underlying epidermis.
Claim 2
Independent Claim
58 words
A method of facilitating percutaneous transport by overcoming the barrier function of the stratum corneum, said method comprising ablating the stratum corneum of a region of the skin of said patient using pulsed laser light of wavelength, pulse length, pulse energy, pulse number, and pulse repetition rate sufficient to ablate said corneum without significantly damaging the underlying epidermis.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein said pulse repetition rate is less than 2 Hz.
Claim 4
Dependent Claim
37 words
The method of claim 1 wherein there is interposed between the skin of said patient and said pulsed laser light an aperture adapted to limit the laser light illuminating the skin of said patient to said region.
Claim 5
Dependent Claim
13 words
The method of claim 1, wherein said pulsed laser light is near infrared.
Claim 6
Dependent Claim
24 words
The method of claim 1, wherein said pulsed laser light has a pulse energy equal to or less than 170 mJ/cm 2 per pulse.
Claim 7
Dependent Claim
20 words
The method of claim 5, wherein said pulse energy is equal to or less than 100 mJ/cm 2 per pulse.
Claim 8
Dependent Claim
19 words
The method of claim 1, further comprising the step of applying a therapeutic substance to said region of ablation.
Claim 9
Dependent Claim
28 words
The method of claim 7 wherein said therapeutic substance comprises a polar compound, a peptide hormone, a non-peptide hormone, a non-hormone peptide or protein, or a gaseous anesthetic.
References Cited (Backward Citations)
EP0111060A1
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-10-04 | 1992-04-04 | 1992-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-04 | 1996-04-04 | 1996-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-04 | 2000-04-04 | 2000-10-04 | $7700.00 | Window Closed / Lapsed |