US4772559A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of detecting the presence of bronchogenic carcinoma by analysis of expired lung air
Assignee: Monell Chemical Senses Center
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Filing: 1987-03-31
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Granted: 1988-09-20
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Expires: 2007-03-31
Abstract
Abstract A novel method of detecting and diagnosing lung cancers by monitoring and analyzing expired lung air for the presence of selected aromatic amines, particularly aniline and ortho-toluidine, is provided.
Inventors
- 👤 George Preti
- 👤 John N. Labows
- 👤 Ronald Daniele
- 👤 James G. Kostelc
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:46
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/497; Y; Y10; Y10S; Y10S436/00; Y10S436/811; Y10S436/813; Y10S436/90; Y10T; Y10T436/00; Y10T436/14; Y10T436/145555; Y10T436/17; Y10T436/173845; Y10T436/21; Y10T436/212
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
79 words
A method for screening an individual to determine the probability of bronchogenic carcinoma in that individual comprising the steps of: (a) collecting a sample of expired lung air from that individual; and (b) presenting that sample to an indicator means which responds specifically to a diagnostically indicative compound in that sample, said indicative compound being selected from the group consisting of aniline and o-toluidine, whereby a positive response to said indicative compound indicates an increased probability of biochogenic carcinoma.
Claim 2
Independent Claim
79 words
A method for screening an individual to determine the probability of bronchogenic carcinoma in that individual comprising the steps of: (a) collecting a sample of expired lung air from that individual; and (b) presenting that sample to an indicator means which responds specifically to a diagnostically indicative compound in that sample, said indicative compound being selected from the group consisting of aniline and o-toluidine, whereby a positive response to said indicative compound indicates an increased probability of biochogenic carcinoma.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein step (b) comprises providing an indicator means responsive to aniline.
Claim 4
Dependent Claim
12 words
The method of claim 2 wherein said indicator means also respond quantitatively.
Claim 5
Dependent Claim
42 words
The method of claim 3 which further comprises the steps of (c) repeating steps (a) and (b); and (d) comparing the response from the later performed step (b) with the earlier performed step (b) to monitor a change in the disease state.
Claim 6
Dependent Claim
16 words
The method of claim 1 wherein step (b) comprises providing an indicator means responsive to o-toluidine.
Claim 7
Dependent Claim
12 words
The method of claim 5 wherein said indicator means also respond quantitatively.
Claim 8
Dependent Claim
16 words
The method of claim 1 wherein said indicator means also respond quantitatively to said indicative compound.
Claim 9
Dependent Claim
31 words
The method of claim 7 wherein said quantitative response is compared to normal control amounts, whereby a higher concentration of said compound is indicative of a higher probability of said carcinoma.
Claim 10
Dependent Claim
42 words
The method of claim 8 which further comprises the steps of (c) repeating steps (a) and (b); and (d) comparing the response from the later performed step (b) with the earlier performed step (b) to monitor a change in the disease state.
Claim 11
Dependent Claim
42 words
The method of claim 7 which further comprises the steps of (c) repeating steps (a) and (b); and (d) comparing the response from the later performed step (b) with the earlier performed step (b) to monitor a change in the disease state.
References Cited (Backward Citations)
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US3622278A
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US3787184A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-20 | 1992-03-21 | 1992-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-20 | 1996-03-21 | 1996-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-20 | 2000-03-21 | 2000-09-20 | $7700.00 | Window Closed / Lapsed |