US4334540A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of diagnosing periodontal disease through the detection of pyridine compounds
Assignee: Monell Chemical Senses Center
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Filing: 1979-05-01
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Granted: 1982-06-15
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Expires: 1999-05-01
Abstract
Abstract A novel method of diagnosing periodontal disease is disclosed wherein telltale pyridine and alkyl-pyridine compounds which are detected in the oral cavity are indicative of periodontal disease. An alternate embodiment method is disclosed wherein increased concentrations of certain other compounds are detected to confirm the presence of periodontal disease.
Inventors
- 👤 George Preti
- 👤 James G. Kostelc
- 👤 Philip R. Zelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:00
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; Y; Y10; Y10T; Y10T436/00; Y10T436/14
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
89 words
A method of evaluating an individual to determine and diagnose the existence of periodontal disease in the oral cavity of that individual, comprising the steps of: (a) collecting a test substance from the oral cavity of the individual to be evaluated; and (b) presenting that test substance to an indicator means for selectively responding at least qualitatively to the presence of at least one indicative diagnostic pyridine compound in that test substance, whereby a qualitative response of said indicator means diagnoses the existence of periodontal disease in said individual.
Claim 2
Independent Claim
89 words
A method of evaluating an individual to determine and diagnose the existence of periodontal disease in the oral cavity of that individual, comprising the steps of: (a) collecting a test substance from the oral cavity of the individual to be evaluated; and (b) presenting that test substance to an indicator means for selectively responding at least qualitatively to the presence of at least one indicative diagnostic pyridine compound in that test substance, whereby a qualitative response of said indicator means diagnoses the existence of periodontal disease in said individual.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein step (a) comprises collecting saliva from that individual.
Claim 4
Dependent Claim
24 words
The method of claim 2 wherein step (a) comprises the steps of incubating said saliva and collecting air from the headspace adjacent said saliva.
Claim 5
Dependent Claim
20 words
The method of claim 1 wherein step (a) comprises collecting air from at least one gingival crevice of said individual.
Claim 6
Dependent Claim
15 words
The method of claim 1 wherein step (a) comprises collecting mouth air from said individual.
Claim 7
Dependent Claim
20 words
The method of claim 1 wherein step (b) comprises providing an indicator means for qualitatively responding to at least pyridine.
Claim 8
Dependent Claim
21 words
The method of claim 1 wherein step (b) comprises providing an indicator means for qualitatively responding to at least a picoline.
Claim 9
Dependent Claim
21 words
The method of claim 1 wherein step (b) comprises providing an indicator means for qualitatively responding to at least 2-methyl pyridine.
Claim 10
Dependent Claim
21 words
The method of claim 1 wherein step (b) comprises providing an indicator means for qualitatively responding to at least 3-methyl pyridine.
Claim 11
Dependent Claim
41 words
The method of claim 1 wherein said indicator means also responds quantitatively to at least a second indicative diagnostic compound to sense and indicate increased concentrations thereof, said increased concentrations being indicative of the existence of periodontal disease in said individual.
Claim 12
Dependent Claim
18 words
The method of claim 10 wherein said indicator means responds quantitatively to sense and indicate concentrations of p-cresol.
Claim 13
Dependent Claim
19 words
The method of claim 10 wherein said indicator means responds quantitatively to sense and indicate increased concentrations of phenol.
Claim 14
Dependent Claim
19 words
The method of claim 10 wherein said indicator means responds quantitatively to sense and indicate increased concentrations of dimethyltrisulfide.
Claim 15
Dependent Claim
19 words
The method of claim 10 wherein said indicator means responds quantitatively to sense and indicate increased concentrations of dimethyldisulfide.
Claim 16
Dependent Claim
19 words
The method of claim 10 wherein said indicator means responds quantitatively to sense and indicate increased concentrations of hexadecanol.
Claim 17
Dependent Claim
19 words
The method of claim 10 wherein said indicator means responds quantitatively to sense and indicate increased concentrations of tetradecanol.
Claim 18
Dependent Claim
19 words
The method of claim 10 wherein said indicator means responds quantitatively to sense and indicate increased concentrations of dodecanol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-14 | 1985-12-14 | 1986-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-14 | 1989-12-14 | 1990-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-14 | 1993-12-14 | 1994-06-15 | $7700.00 | Window Closed / Lapsed |