US4753776A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood separation device comprising a filter and a capillary flow pathway exiting the filter
Assignee: Roche Diagnostics Operations Inc
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Filing: 1986-10-29
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Granted: 1988-06-28
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Expires: 2006-10-29
Abstract
Abstract A method for separating plasma from red blood cells and a device utilizing the method in which a low-pressure filter is interposed in a pathway between an inlet port and a reaction area. The sole driving force for the movement of plasma from the filter to the reaction area is capillary force provided by a tubular capillary. The filter is selected from glass microfiber filters of specified characteristics, which can operate in the absence of agglutinins, and filters capable of separating agglutinated red cells from plasma, which require the use of an agglutinin.
Inventors
- 👤 Robert S. Hillman
- 👤 Ian Gibbons
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:28
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5027; B01L3/502753; B01D; B01D39/00; B01D39/14; B01D39/20; B01D39/2003; B01D39/2017; B01D61/00; B01D61/14; B01D61/18; G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; B01D2239/00; B01D2239/12; B01D2239/1216; B01D2239/1233; B01D2239/125; B01L2300/00; B01L2300/06; B01L2300/0681; B01L2300/08; B01L2300/0809; B01L2300/0816; B01L2400/00; B01L2400/04; B01L2400/0403; B01L2400/0406
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
178 words
In a clinical diagnostic device comprising a housing having a fluid inlet port, a vented reaction area, and a capillary pathway connecting said inlet port and said reaction area and in which the driving force for the movement of liquid through said capillary pathway arises from capillary pressure, an improvement which comprises: a low-pressure filter interposed in said pathway, wherein said filter is selected from the group consisting of binderless glass microfiber filters having a particle size retention in the range from about 1 μm to about 3 μm, a flow path of from about 0.5 to about 0.5 mm, and a density in the range from about 0.10 to 0.30 g/cm 3 and comprises glass fibers having diameters essentially all in the range of from 0.10 to 4.0 μm with at least 60% of the fibers having diameters in the range of from 0.10 to 1.23 μm, wherein said device contains no agglutinin for red blood cells, whereby whole blood applied to said inlet port is separated into plasma and red blood cells by said low-pressure filter.
Claim 2
Dependent Claim
178 words
In a clinical diagnostic device comprising a housing having a fluid inlet port, a vented reaction area, and a capillary pathway connecting said inlet port and said reaction area and in which the driving force for the movement of liquid through said capillary pathway arises from capillary pressure, an improvement which comprises: a low-pressure filter interposed in said pathway, wherein said filter is selected from the group consisting of binderless glass microfiber filters having a particle size retention in the range from about 1 μm to about 3 μm, a flow path of from about 0.5 to about 0.5 mm, and a density in the range from about 0.10 to 0.30 g/cm 3 and comprises glass fibers having diameters essentially all in the range of from 0.10 to 4.0 μm with at least 60% of the fibers having diameters in the range of from 0.10 to 1.23 μm, wherein said device contains no agglutinin for red blood cells, whereby whole blood applied to said inlet port is separated into plasma and red blood cells by said low-pressure filter.
Claim 3
Dependent Claim
14 words
The device of claim 1, wherein said filter consists essentially of borosilicate glass fibers.
Claim 4
Dependent Claim
67 words
The device of claim 2, wherein said filter has a thickness of 0.50 to 0.80 nm, a particle size retention of from about 2.3 to 3.0 μm, and comprises glass fibers having diameters distributed over said range of from 0.10 to 1.23 μm so that 3 or 4 equal divisions of said range each contains a number of fibers varying by no more than 10 number percent.
References Cited (Backward Citations)
US2910406A
Cited
US3464890A
Cited
US3843324A
Cited
US4157967A
Cited
US4310399A
Cited
US4477575A
Cited
US4477575B1
Cited
US4426451A
Cited
US4696797A
Cited
US4623461A
Cited
US4693834A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-28 | 1991-12-28 | 1992-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-28 | 1995-12-28 | 1996-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-28 | 1999-12-28 | 2000-06-28 | $7700.00 | Window Closed / Lapsed |