US3983227A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dry mixture containing diphosphonates and a stannous salt useful in the preparation of Tc99M containing bone scanning agents
Assignee: Mallinckrodt Inc
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Filing: 1974-04-19
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Granted: 1976-09-28
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Expires: 1994-04-19
Abstract
Abstract A composition and method for the preparation of a technetium-99m based scintigraphic scanning agent are disclosed. The agent is prepared by the addition of a pertechnetate-99m solution to an anhydrous salt composition comprising a phosphonic acid or a pharmaceutically acceptable salt thereof and a non-toxic, water-soluble, anhydrous, stannous, ferrous or chromous salt of hydrochloric or sulfuric acid.
Inventors
- 👤 Andrew John Tofe
- 👤 Marion David Francis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:32
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1282; A61K51/02; A61K51/04; A61K51/0489; A61K2123/00; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/108331
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
113 words
A composition for the preparation of an improved bone scanning agent comprising a dry mixture of: A. a phoshonate which is a member selected from the group consisting of (i) disodium-ethane-1-hydroxy-1,1-diphosphonate, (ii) a mixture of disodium- and trisodium-ethane-1-hydroxy-1,1-diphosphonate salts, the mole ratio of the disodium to trisodium salt being from about 4:1 to 1:1, (iii) dichloromethane diphosphonic acid, or the pharmaceutically acceptable salts thereof, and (iv) methane diphosphonic acid, or the pharmaceutically acceptable salts thereof; B. an amount of an anhydrous reducing metal salt which is a member selected from the group consisting of stannous chloride and stannous sulfate sufficient to provide a molar ratio of stannous:phosphonate of from about 1:15 to 1:80.
Claim 2
Dependent Claim
113 words
A composition for the preparation of an improved bone scanning agent comprising a dry mixture of: A. a phoshonate which is a member selected from the group consisting of (i) disodium-ethane-1-hydroxy-1,1-diphosphonate, (ii) a mixture of disodium- and trisodium-ethane-1-hydroxy-1,1-diphosphonate salts, the mole ratio of the disodium to trisodium salt being from about 4:1 to 1:1, (iii) dichloromethane diphosphonic acid, or the pharmaceutically acceptable salts thereof, and (iv) methane diphosphonic acid, or the pharmaceutically acceptable salts thereof; B. an amount of an anhydrous reducing metal salt which is a member selected from the group consisting of stannous chloride and stannous sulfate sufficient to provide a molar ratio of stannous:phosphonate of from about 1:15 to 1:80.
Claim 3
Dependent Claim
34 words
A composition according to claim 1 wherein the phosphonate is a mixture of disodium- and trisodium-ethane-1-hydroxy-1,1-disphosphonate salts at a mole ratio of the disodium salt to the trisodium salt from about 3:1 to 1:1.
Claim 4
Dependent Claim
14 words
A composition according to claim 2 wherein the reducing metal salt is stannous chloride.
Claim 5
Dependent Claim
17 words
A composition according to claim 14 wherein the phosphonate is a sodium salt of dichloromethane diphosphonic acid.
Claim 6
Dependent Claim
16 words
The composition of claim 1 wherein the phosphonate is a sodium salt of methane diphosphonic acid.
Claim 7
Dependent Claim
16 words
The composition of claim 1 which additionally contains about 1 to 50 parts of sodium chloride.
Claim 8
Dependent Claim
68 words
A composition according to claim 1 consisting essentially of a dry mixture of: A. disodium- and trisodium-ethane-1-hydroxy-1,1-diphosphonate salts, at a mole ratio of the disodium salt to trisodium salt from about 3:1 to 1:1; B. an amount of stannous chloride sufficient to produce a mole ratio of stannous to phosphonate of from about 1:15 to 1:80; and c. from about 1 part to 50 parts of sodium chloride.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-28 | 1980-03-29 | 1980-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-28 | 1984-03-29 | 1984-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-28 | 1988-03-29 | 1988-09-28 | $7700.00 | Window Closed / Lapsed |