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US4745161A Expired / Lapsed US ⏱️ 0.0 years remaining

Soluble and biodegradable polyamino acid activated for bonding of biologically active compound

Assignee: CESKOSLVOENSKA AKADEMIE VED
•
Filing: 1986-04-01
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Granted: 1988-05-17
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Expires: 2006-04-01
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Abstract

Abstract The invention pertains to copolymers activated for bonding of biologically active compounds and to a method for preparation thereof. Soluble and biodegradable copolymers activated for bonding of biologically active compounds which have their main chain formed from units of aspartic acid or glutamic acid, or both, or also from units of other amino acids, according to the general formula I ##STR1## where n is 1 or 2, m is 1 or 2, a+b+c is 100, a is 0.5 to 100, b is 0 to 99.5, c is 0 to 80; the substituent R 1 is --NH--NH 2 , --N.tbd.N or ##STR2## where x is 2 to 6, R 2 is --NH(CH 2 ) x OH where x=2 to 6; and R 3 is methyl, 2-propyl, 2-methylpropyl, butyl, 2-butyl, benzyl or 4-hydroxybenzyl, and the molecular weight is 5,000 to 1,000,000.

Inventors

  • 👤 Vladimir Saudek
  • 👤 Frantisek Rypacek
  • 👤 Jaroslav Drobnik

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 17:52
CPC Classifications
C; C08; C08G; C08G73/00; C08G73/06; C08G73/10; C08G73/1092; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; C08G69/00; C08G69/02; C08G69/08; C08G69/10

Claims Analysis

Total Claims: 3
Claim 1
Independent Claim 119 words
A biodegradable copolymer activated for bonding of biologically active compounds, wherein the main chain of the copolymer is formed from the units of aspartic acid or glutamic acid, or from both these units, or also from units of other amino acids, according to the general formula I ##STR7## where n is 1 or 2, m is 1 or 2, a+b+c is 100, a is 0.5 to 100, b is 0 to 99.5, c is 0 to 80, substituent R 1 is --NH--NH 2 , --N.tbd.N or ##STR8## where x is 2 to 6; R 2 is --NH(CH 2 ) x OH where x is 2 to 6; and R 3 is methyl, 2-propyl, 2-methylpropyl, butyl, 2-butyl, benzyl or 4-hydroxybenzyl.
Claim 2
Dependent Claim 119 words
A biodegradable copolymer activated for bonding of biologically active compounds, wherein the main chain of the copolymer is formed from the units of aspartic acid or glutamic acid, or from both these units, or also from units of other amino acids, according to the general formula I ##STR7## where n is 1 or 2, m is 1 or 2, a+b+c is 100, a is 0.5 to 100, b is 0 to 99.5, c is 0 to 80, substituent R 1 is --NH--NH 2 , --N.tbd.N or ##STR8## where x is 2 to 6; R 2 is --NH(CH 2 ) x OH where x is 2 to 6; and R 3 is methyl, 2-propyl, 2-methylpropyl, butyl, 2-butyl, benzyl or 4-hydroxybenzyl.
Claim 3
Dependent Claim 114 words
Method for preparation of the copolymer according to claim 1, wherein a polymer having units of the general formula II ##STR9## where R is methyl or benzyl, n is 1 or 2, m is 1 or 2, a+b+c is 100, a is 0.5 to 100, b is 0 to 99.5, c is 0 to 80; R 2 is R or is the same as in claim 1; and R 3 is the same as in the general formula I; is treated at 0° C. to 60° C. with a mixture containing primary or secondary amino alkylalcohol, wherein the alkyl is a linear or branched hydrocarbon chain having 2 to 6 carbon atoms, and hydrazine.

References Cited (Backward Citations)

JPS498590A Cited
US4435547A Cited
JPH0917084A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1991-05-17 1991-11-16 1992-05-17 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1995-05-17 1995-11-16 1996-05-17 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1999-05-17 1999-11-16 2000-05-17 $7700.00 Window Closed / Lapsed

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