US4745106A
Expired / Lapsed
US
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Heparin derivatives having improved anti-Xa specificity
Assignee: Miami University
•
Filing: 1986-08-20
•
Granted: 1988-05-17
•
Expires: 2006-08-20
Abstract
Abstract Acetyl ester derivatives of heparin are disclosed. These derivatives exhibit improved Anti-Xa activity in relation to their global anticlotting activity.
Inventors
- 👤 Charles C. Griffin
- 👤 Kevin M. Foley
- 👤 Eduardo Amaya
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:44
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
12 words
An ester of heparin characterized by an anti-Xa/APTT ratio greater than 1.5.
Claim 2
Dependent Claim
12 words
An ester of heparin characterized by an anti-Xa/APTT ratio greater than 1.5.
Claim 3
Dependent Claim
17 words
An ester of claim 1 wherein the ester is prepared by reacting an acid chloride with heparin.
Claim 4
Dependent Claim
15 words
An ester of claim 1 wherein more than 50% of the ester groups are aliphatic.
Claim 5
Dependent Claim
14 words
An ester of claim 3 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 6
Dependent Claim
13 words
An ester of heparin containing more than 0.1 acetyl groups per tgetrasaccharide unit.
Claim 7
Dependent Claim
13 words
An ester of heparin containing more than 0.1 acetyl groups per tgetrasaccharide unit.
Claim 8
Dependent Claim
16 words
An ester of claim 5 wherein the ester is prepared by reacting acetyl chloride with heparin.
Claim 9
Dependent Claim
26 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5.
Claim 10
Dependent Claim
26 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5.
Claim 11
Dependent Claim
17 words
An ester of claim 7 wherein the ester is prepared by reacting an acid chloride with heparin.
Claim 12
Dependent Claim
27 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester containing more than 0.1 acetyl groups per tetrasaccharide unit.
Claim 13
Dependent Claim
27 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester containing more than 0.1 acetyl groups per tetrasaccharide unit.
Claim 14
Dependent Claim
16 words
An ester of claim 9 wherein the ester is prepared by reacting acetyl chloride with heparin.
Claim 15
Dependent Claim
35 words
An ester of heparin characterized by an anti-Xa/APTT ratio greater than 1.5, wherein the ester is prepared by reacting an acid chloride with heparin, and wherein more than 50% of the ester groups are aliphatic.
Claim 16
Dependent Claim
35 words
An ester of heparin characterized by an anti-Xa/APTT ratio greater than 1.5, wherein the ester is prepared by reacting an acid chloride with heparin, and wherein more than 50% of the ester groups are aliphatic.
Claim 17
Dependent Claim
47 words
An ester of heparin characterized by an anti-Xa/APTT ratio greater than 1.5, wherein the ester is prepared by reacting an acid chloride with heparin, wherein more than 50% of the ester groups are aliphatic and wherein the ester contains more than 0.1 ester groups per tetrasaccharide unit.
Claim 18
Dependent Claim
47 words
An ester of heparin characterized by an anti-Xa/APTT ratio greater than 1.5, wherein the ester is prepared by reacting an acid chloride with heparin, wherein more than 50% of the ester groups are aliphatic and wherein the ester contains more than 0.1 ester groups per tetrasaccharide unit.
Claim 19
Dependent Claim
49 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5, wherein the ester is prepared by reacting an acid chloride with heparin, and wherein more than 50% of the ester groups are aliphatic.
Claim 20
Dependent Claim
49 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5, wherein the ester is prepared by reacting an acid chloride with heparin, and wherein more than 50% of the ester groups are aliphatic.
Claim 21
Dependent Claim
61 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5, wherein the ester is prepared by reacting an acid chloride with heparin, wherein more than 50% of the ester groups are aliphatic and wherein the ester contains more than 0.1 ester groups per tetrasaccharide unit.
Claim 22
Dependent Claim
61 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5, wherein the ester is prepared by reacting an acid chloride with heparin, wherein more than 50% of the ester groups are aliphatic and wherein the ester contains more than 0.1 ester groups per tetrasaccharide unit.
Claim 23
Dependent Claim
36 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5, wherein more than 50% of the ester groups are aliphatic.
Claim 24
Dependent Claim
36 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5, wherein more than 50% of the ester groups are aliphatic.
Claim 25
Dependent Claim
49 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5, wherein more than 50% of the ester groups are aliphatic and wherein the ester contains more than 0.1 ester groups per tetrasaccharide unit.
Claim 26
Dependent Claim
49 words
An ester of heparin formed by replacing the free hydroxyl groups of heparin with ester groups, said ester characterized by an anti-Xa/APTT ratio greater than 1.5, wherein more than 50% of the ester groups are aliphatic and wherein the ester contains more than 0.1 ester groups per tetrasaccharide unit.
Claim 27
Dependent Claim
27 words
A pharmaceutically active composition comprising a pharmaceutically acceptable carrier or diluent and, as the pharmaceutically active component, a product as claimed in any one of claims 1-16
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-17 | 1991-11-16 | 1992-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-17 | 1995-11-16 | 1996-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-17 | 1999-11-16 | 2000-05-17 | $7700.00 | Window Closed / Lapsed |