Patent US837512A successfully refreshed from Google Patents.
Patent US4714460A successfully refreshed from Google Patents.
US4714460A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods and systems for retrograde perfusion in the body for curing it of the disease or immume deficiency
Assignee: Individual
•
Filing: 1986-06-06
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Granted: 1987-12-22
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Expires: 2006-06-06
Abstract
Abstract Catheter feedback methods and systems are disclosed for optimizing the infusion of a drug, such as a chemotherapeutic agent via retrograde perfusion through the venous side of the vascular network to a selectively determined portion of a solid tumor. Monitoring and regulatory capability are provided for controlling the outflow of the drug and thereby for controlling the dose rate, the duration of exposure of the drug, the leakage factor, and the level of systemic toxicity, all critical factors in the successful treatment of solid tumors. A feedback loop for practicing the method comprises two concentric balloon catheters capable of extensive maneuvering and selective placement within the venous drainage of the vascular system, creating a third in-vivo space for repeated perfusion of the selected portion of a diseased organ as often as desired, providing maximum exposure of the chemotherapy to the tumor with minimum exposure to any other portions of the patient's body.
Inventors
- 👤 Reynaldo Calderon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:33
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/0021; A61M25/0023; A61M25/0026; A61M1/00; A61M1/36; A61M1/3613; A61M1/3615; A61M25/10; A61M25/1011; A61M25/01; A61M25/09; A61M2025/09175; A61M2025/09183; A61M2025/1015
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
127 words
A method for treating a tumor in the body of a patient, comprising the steps of: (a) placing a catheter having a suction lumen and an infusion lumen extending beyond the suction lumen and a seal associated with each of such lumens in a vein of the patient near the tumor; (b) sealing the flow of fluid in the patient's vein between the infusion lumen and the suction lumen with the infusion seal; (c) sealing the flow of fluid in the patient's vein past the suction lumen with the suction seal; (d) injecting a chemotherapeutic agent from the infusion lumen into the patient's vein so that it may perfuse through the tumor; and (e) collecting the chemotherapeutic agent in the suction lumen after perfusion through the tumor.
Claim 2
Independent Claim
127 words
A method for treating a tumor in the body of a patient, comprising the steps of: (a) placing a catheter having a suction lumen and an infusion lumen extending beyond the suction lumen and a seal associated with each of such lumens in a vein of the patient near the tumor; (b) sealing the flow of fluid in the patient's vein between the infusion lumen and the suction lumen with the infusion seal; (c) sealing the flow of fluid in the patient's vein past the suction lumen with the suction seal; (d) injecting a chemotherapeutic agent from the infusion lumen into the patient's vein so that it may perfuse through the tumor; and (e) collecting the chemotherapeutic agent in the suction lumen after perfusion through the tumor.
Claim 3
Dependent Claim
15 words
The method of claim 1, further including the step of: analyzing the collected chemotherapeutic agent.
Claim 4
Dependent Claim
15 words
The method of claim 1, further including the step of: filtering the collected chemotherapeutic agent.
Claim 5
Dependent Claim
21 words
The method of claim 3, further including the step of: re-injecting the filtered chemotherapeutic agent into the vein of the patient.
Claim 6
Dependent Claim
22 words
The method of claim 1, further including the step of: maintaining the rate of collection substantially equal to the rate of injection.
Claim 7
Dependent Claim
27 words
The method of claim 1, further including the step of: mapping a selected portion of the tumor blood vessels prior to said step of placing the catheter.
Claim 8
Dependent Claim
31 words
The method of claim 1, further including the step of: testing the patient's venous system for possible leakage past the suction seal prior to said step of injecting a chemotherapeutic agent.
Claim 9
Dependent Claim
128 words
A catheter apparatus for treating a tumor in the body of a patient with a chemotherapeutic agent, comprising: (a) catheter means for location in a vein of the patient near the tumor, said catheter means comprising: (1) a suction lumen; and (2) an infusion lumen extending beyond said suction lumen; (b) infusion seal means on said catheter means between said infusion lumen and said suction lumen; (c) suction seal means on said catheter means for sealing the flow of fluid in the patient's vein past said suction lumen; (d) means for injecting a chemotherapeutic agent into the patient's vein from said injection lumen so that it may perfuse through the tumor; and (e) means for collecting the chemotherapeutic agent from said suction lumen after perfusion through the tumor.
Claim 10
Dependent Claim
128 words
A catheter apparatus for treating a tumor in the body of a patient with a chemotherapeutic agent, comprising: (a) catheter means for location in a vein of the patient near the tumor, said catheter means comprising: (1) a suction lumen; and (2) an infusion lumen extending beyond said suction lumen; (b) infusion seal means on said catheter means between said infusion lumen and said suction lumen; (c) suction seal means on said catheter means for sealing the flow of fluid in the patient's vein past said suction lumen; (d) means for injecting a chemotherapeutic agent into the patient's vein from said injection lumen so that it may perfuse through the tumor; and (e) means for collecting the chemotherapeutic agent from said suction lumen after perfusion through the tumor.
Claim 11
Dependent Claim
14 words
The apparatus of claim 8, further including: means for analyzing the collected chemotherapeutic agent.
Claim 12
Dependent Claim
14 words
The apparatus of claim 8, further including: means for filtering the collected chemotherapeutic agent.
Claim 13
Dependent Claim
20 words
The apparatus of claim 12, further including: means for re-injecting the filtered chemotherapeutic agent into the vein of the patient.
Claim 14
Dependent Claim
29 words
The apparatus of claim 8, further including: means maintaining the rate of collection at said suction lumen substantially equal to the rate of injection at said injection catheter means.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-21 | 1991-06-22 | 1991-12-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-21 | 1995-06-22 | 1995-12-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-21 | 1999-06-22 | 1999-12-22 | $7700.00 | Window Closed / Lapsed |