Patent US6655961B2 successfully refreshed from Google Patents.
US4708716A
Expired / Lapsed
US
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Transdermal drug applicator
Assignee: Drug Delivery Systems Inc
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Filing: 1985-09-16
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Granted: 1987-11-24
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Expires: 2005-09-16
Abstract
Abstract A transdermal drug applicator for application to a body for the migration of medicament through the skin into the blood stream of a patient embodies a plurality of reservoirs for containing the medicament. A battery which supplies a charge for the medicament in the applicator is disposed adjacent one side of the reservoirs with a side of the battery facing the reservoir for charging/driving the medicament. Also, a cover comprising an electrically conductive material partially encloses the battery and one side of the reservoir opposite that of the battery is exposed for contacting the skin. An electrical circuit is further provided for electrically connecting the battery to the cover, and the cover having a lip defining the periphery of the applicator for making contact with the skin when mounted on the skin leaving the battery and reservoir generally fully enclosed. An electrically conductive adhesive material coating is disposed on the underside of the lip, said reservoir renders the applicator conformable to the body contours of the patient, and when the applicator is adhered to and mounted on the skin a complete electrical circuit through the skin is formed and the medicament in the reservoir migrates out of the reservoir and through the skin into the patient's blood stream.
Inventors
- 👤 Dan Sibalis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:46
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0432; A61N1/044; A61M; A61M37/00; A61N1/0448
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
267 words
A transdermal drug applicator for application to the body for migration of medicament through the skin to the blood stream of a patient comprising: reservoir means containing at least one medicament, battery means for supplying a current to said applicator and being close to said reservoir means for charging/driving the medicament, means for covering comprising an electrically conductive material for partially enclosing at least said reservoir means leaving the side of said reservoir means opposite that of said battery means exposed for contacting said skin, means for electrically connecting the battery means to the cover means, said cover means having lip means for making contact with said skin when mounted on said skin leaving at least said reservoir means substantially fully enclosed, an electrically conductive adhesive material coating disposed on a side of said lip means in contact with the skin when in use, and a sensing electrode and circuit means in a feedback loop mounted on said skin when in use and connected with said electrical circuit for sensing a predetermined chemical in said body and providing a control signal for regulating drug dosage at a desired level, said applicator being generally conformable to the body contour of said patient, whereby when said applicator is adhered to and mounted on said skin a complete electrical circuit through said skin is formed and a medicament in said reservoir means migrates out of said reservoir means and through said skin into the blood stream of said patient, due to the mass transfer activity attributed to at least one phenomena selected from the group consisting of electrophoresis and electro-osmosis.
Claim 2
Dependent Claim
267 words
A transdermal drug applicator for application to the body for migration of medicament through the skin to the blood stream of a patient comprising: reservoir means containing at least one medicament, battery means for supplying a current to said applicator and being close to said reservoir means for charging/driving the medicament, means for covering comprising an electrically conductive material for partially enclosing at least said reservoir means leaving the side of said reservoir means opposite that of said battery means exposed for contacting said skin, means for electrically connecting the battery means to the cover means, said cover means having lip means for making contact with said skin when mounted on said skin leaving at least said reservoir means substantially fully enclosed, an electrically conductive adhesive material coating disposed on a side of said lip means in contact with the skin when in use, and a sensing electrode and circuit means in a feedback loop mounted on said skin when in use and connected with said electrical circuit for sensing a predetermined chemical in said body and providing a control signal for regulating drug dosage at a desired level, said applicator being generally conformable to the body contour of said patient, whereby when said applicator is adhered to and mounted on said skin a complete electrical circuit through said skin is formed and a medicament in said reservoir means migrates out of said reservoir means and through said skin into the blood stream of said patient, due to the mass transfer activity attributed to at least one phenomena selected from the group consisting of electrophoresis and electro-osmosis.
Claim 3
Dependent Claim
26 words
The transdermal drug applicator of claim 1, in which said reservoir means is made from a microporous material whereby said medicament provides an electrical path therethrough.
Claim 4
Dependent Claim
24 words
The transdermal drug applicator of claim 2, said circuit having means to maintain constant current flow during the period said medicament is being delivered.
Claim 5
Dependent Claim
26 words
The transdermal drug applicator of claim 3, wherein said circuit having means to terminate deposition of said medicament after a predetermined quantity of medicament is delivered.
Claim 6
Dependent Claim
62 words
The transdermal drug applicator of claim 1, including a plurality of reservoir means forming separate cell-like reservoirs for said medicament, and each said reservoir cell embodies the same structural layered elements so as to individually charge said medicament by said battery means for causing the migration of said medicament in said reservoir cells through said skin and into the patient's blood stream.
Claim 7
Dependent Claim
42 words
The transdermal drug applicator of claim 5, wherein said applicator is divided into a plurality of sections, each with battery means, and said sections being connected together at least at one point, whereby said applicator may be conformable to said body contours.
Claim 8
Dependent Claim
19 words
The transdermal drug applicator of claim 6, including parallel electrical circuit paths for the electrical circuit of said applicator.
Claim 9
Dependent Claim
18 words
The transdermal drug applicator of claim 6, wherein said sections are generally all equal in size and shape.
Claim 10
Dependent Claim
19 words
The transdermal drug applicator of claim 8, wherein each said section is provided with at least one reservoir cell.
Claim 11
Dependent Claim
29 words
The transdermal drug applicator of claim 9, wherein a plurality of reservoir cells form each said section and the number of reservoir cells of said sections are the same.
Claim 12
Dependent Claim
17 words
The transdermal drug applicator of claim 10, wherein the shape of each reservoir cell is the same.
Claim 13
Dependent Claim
19 words
The transdermal drug applicator of claim 10, wherein the shapes of said reservoir cells are not all the same.
Claim 14
Dependent Claim
24 words
The transdermal drug applicator of claim 1, wherein said extra electrode is enclosed by said cover means and is disposed at said lip means.
Claim 15
Dependent Claim
40 words
The transdermal drug applicator of claim 13, wherein said extra electrode comprising a probe having a predetermined ion specific electrode or enzyme coating on the surface of said electrode portion which is in contact with the skin of said patient.
Claim 16
Dependent Claim
30 words
The transdermal drug applicator of claim 14, wherein said extra electrode is disposed in said lip means so as not to electrically interfere with the electrical circuitry of said applicator.
Claim 17
Dependent Claim
29 words
The transdermal drug applicator of claim 15, wherein said distance is such that said lip means extends outwardly and protrudes beyond the basic shape and configuration of said applicator.
Claim 18
Dependent Claim
27 words
The transdermal drug applicator of claim 1, including one or more buffers in said medicament for maintaining the pH value of the medicament at an optimal level.
Claim 19
Dependent Claim
70 words
The transdermal drug applicator of claim 17, wherein the pH of said medicament prior to application of said applicator to one's skin is predetermined at a value which maximizes the shelf life of said drug contained in said applicator, and whereby upon application of said applicator to one's skin the current induced pH change brings the pH within the range of said one or more buffers, thus optimizing drug mobility.
Claim 20
Dependent Claim
13 words
The transdermal drug applicator of claim 1, including a plurality of reservoir means.
Claim 21
Dependent Claim
56 words
The transdermal drug applicator of claim 19, wherein said applicator transdermally delivers a plurality of drugs and said plurality of reservoir means contain different medicaments, and the delivery of each of said medicaments, is independently controlled by at least one means selected from the group consisting of a current regulating means and a chemical regulating means.
Claim 22
Dependent Claim
21 words
The transdermal drug applicator of claim 19, wherein said controlling means is a solid state device pre-programmed for current and time.
Claim 23
Dependent Claim
20 words
The transdermal drug applicator of claim 19, further including means for releasing said different medicaments transdermally in a predetermined sequence,
Claim 24
Dependent Claim
32 words
The applicator according to claim 1, wherein said feedback loop includes an amplifier, and said feedback loop controls the duration of the on and off periods of the oscillations of said amplifier.
Claim 25
Dependent Claim
22 words
The applicator according to claim 23, wherein the duration of the on and off periods of the oscillating amplifier are independently adjustable.
References Cited (Backward Citations)
US385567A
Cited
US486902A
Cited
US588479A
Cited
US2493155A
Cited
US2667162A
Cited
US2784715A
Cited
US3163166A
Cited
US3289671A
Cited
US3547107A
Cited
US3612061A
Cited
US4003379A
Cited
US4008721A
Cited
US4141359A
Cited
US4164226A
Cited
US4325367A
Cited
US4273135A
Cited
US4239046A
Cited
US4250878A
Cited
US4243052A
Cited
US4314554A
Cited
US4292968A
Cited
WO1981002097A1
Cited
US4309996A
Cited
US4367745A
Cited
US4419091A
Cited
FR2500689A3
Cited
US4416274A
Cited
US4406658A
Cited
GB2104388A
Cited
US4474570A
Cited
US4460368A
Cited
US4457748A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-23 | 1991-05-25 | 1991-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-23 | 1995-05-25 | 1995-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-23 | 1999-05-25 | 1999-11-24 | $7700.00 | Window Closed / Lapsed |