US4250878A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-invasive chemical species delivery apparatus and method
Assignee: MOTION CONTROL Inc A CORP OF UTAH
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Filing: 1978-11-22
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Granted: 1981-02-17
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Expires: 1998-11-22
Abstract
Abstract A bioelectrode for non-invasive and inotophoretic delivery of chemical species (such as ions, polar molecules, etc.) into the skin of a person. The bioelectrode includes a pouch having flexible walls, at least a portion of which is composed of a microporous, permeable or semipermeable membrane. The pouch holds fluid which contains the chemical species to be delivered through the skin. An electrode is attached to the pouch so that when the pouch is placed against the skin, with the membrane portion in contact with the skin, and an electric potential is applied to the electrode, chemical species in the pouch are caused to migrate through the membrane and into the skin.
Inventors
- 👤 Stephen C. Jacobsen
- 👤 Jerome C. Stenehjem
- 👤 Robert L. Stephen
- 👤 Richard D. Luntz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:40
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0444; A61N1/0448; A61B; A61B2562/00; A61B2562/02; A61B2562/0209; A61B2562/0217; A61B2562/12; A61B2562/125; A61N1/0432; A61N1/044; A61N1/18; A61N1/20; A61N1/30; A61N1/303; A61N1/306
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
107 words
A bioelectrode for use in the iontophoretic delivery of a chemical species into the skin or tissue of a person comprising a pouch for holding a fluid containing the chemical species, said pouch including flexible and deformable walls adapted to generally conform to surface shapes against which they are placed, at least a portion of which includes a microporous membrane separating the interior of the pouch from the exterior and having openings of about 0.22 microns or less in diameter, said portion being formed to present a generally planar to convex exterior surface, and an electrode carried by said pouch for coupling to an electric potential source.
Claim 2
Dependent Claim
107 words
A bioelectrode for use in the iontophoretic delivery of a chemical species into the skin or tissue of a person comprising a pouch for holding a fluid containing the chemical species, said pouch including flexible and deformable walls adapted to generally conform to surface shapes against which they are placed, at least a portion of which includes a microporous membrane separating the interior of the pouch from the exterior and having openings of about 0.22 microns or less in diameter, said portion being formed to present a generally planar to convex exterior surface, and an electrode carried by said pouch for coupling to an electric potential source.
Claim 3
Dependent Claim
27 words
A bioelectrode as in claim 1 wherein said electrode is mounted on the exterior surface of said walls in electrical contact therewith and spaced from said membrane.
Claim 4
Dependent Claim
16 words
A bioelectrode as in claim 2 wherein said electrode is formed of a flexible conductive material.
Claim 5
Dependent Claim
112 words
A bioelectrode as in claim 1 further comprising a second pouch for holding a fluid containing additional chemical species, said second pouch including flexible and deformable walls adapted to generally conform to surface shapes against which they are placed, at least a portion of which includes a microporous membrane separating the interior of the second pouch from the exterior and having openings of about 0.22 microns or less in diameter, said portion of said second pouch being formed to present a generally planar to convex exterior surface, a second electrode carried by said second pouch for coupling to an electric potential source, and flexible means coupling the first-mentioned and second pouch together.
Claim 6
Dependent Claim
30 words
A bioelectrode as in claim 1 wherein said pouch is formed in the shape of an annulus and wherein said membrane is disposed about the interior circumference of the annulus.
Claim 7
Dependent Claim
27 words
A bioelectrode as in claim 5 wherein said electrode is attached to the exterior surface of said pouch to extend about the exterior circumference of said annulus.
Claim 8
Dependent Claim
34 words
A bioelectrode as in claim 1 wherein said pouch is formed in the shape of an elongate bag, and wherein said electrode is formed in the shape of a rod disposed within said bag.
Claim 9
Dependent Claim
24 words
A bioelectrode as in claim 7 further including a porous, resilient material disposed between said electrode and the interior surface of the pouch walls.
Claim 10
Dependent Claim
24 words
A bioelectrode as in claim 1 wherein said pouch is formed in the shape of a cylinder in which said walls are positioned concentrically.
Claim 11
Dependent Claim
18 words
A bioelectrode as in claim 9 wherein said electrode is attached to the exterior surface of said pouch.
Claim 12
Dependent Claim
23 words
A bioelectrode as in claim 1 further comprising channel means formed in said pouch to enable introduction therethrough of fluid into said pouch.
Claim 13
Dependent Claim
111 words
A bioelectrode for use in the iontophoretic delivery of a chemical species into the skin or tissue of a person comprising a pouch for holding a fluid containing the chemical species, said pouch including a first flexible and deformable wall portion constructed of a semipermeable membrane having openings of about 0.22 microns or less in diameter, said first wall portion being adapted to allow passage therethrough of certain ions and molecules but to block passage of certain other molecules, and a second flexible and deformable wall portion disposed in a generally facing relationship with said wall portion, and an electrode carried by said pouch for coupling to an electric potential source.
Claim 14
Dependent Claim
111 words
A bioelectrode for use in the iontophoretic delivery of a chemical species into the skin or tissue of a person comprising a pouch for holding a fluid containing the chemical species, said pouch including a first flexible and deformable wall portion constructed of a semipermeable membrane having openings of about 0.22 microns or less in diameter, said first wall portion being adapted to allow passage therethrough of certain ions and molecules but to block passage of certain other molecules, and a second flexible and deformable wall portion disposed in a generally facing relationship with said wall portion, and an electrode carried by said pouch for coupling to an electric potential source.
Claim 15
Dependent Claim
24 words
A bioelectrode as in claim 12 wherein said electrode is mounted on the exterior surface of said second wall portion in electrical contact therewith.
Claim 16
Independent Claim
138 words
A method of non-invasively delivering chemical species into the skin or tissue of a person comprising, placing against the skin or tissue a pouch holding a fluid containing said chemical species, said pouch having flexible walls, one of which consists of a microporous or semipermeable membrane which is positioned in contact with the skin or tissue, applying pressure to said pouch to cause that portion of the pouch in contact with the skin or tissue to conform to the surface shape of the skin or tissue, applying a first electric potential to a portion of the skin or tissue spaced from the location of contact of said pouch, and applying a second electric potential to an exterior surface of said pouch to cause the migration of the chemical species through said membrane and into the skin or tissue.
Claim 17
Independent Claim
138 words
A method of non-invasively delivering chemical species into the skin or tissue of a person comprising, placing against the skin or tissue a pouch holding a fluid containing said chemical species, said pouch having flexible walls, one of which consists of a microporous or semipermeable membrane which is positioned in contact with the skin or tissue, applying pressure to said pouch to cause that portion of the pouch in contact with the skin or tissue to conform to the surface shape of the skin or tissue, applying a first electric potential to a portion of the skin or tissue spaced from the location of contact of said pouch, and applying a second electric potential to an exterior surface of said pouch to cause the migration of the chemical species through said membrane and into the skin or tissue.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-17 | 1984-08-18 | 1985-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-17 | 1988-08-18 | 1989-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-17 | 1992-08-18 | 1993-02-17 | $7700.00 | Window Closed / Lapsed |