US4676776A — Device and method for effecting application of a …

Claim 1

Independent Claim 104 words

A device for effecting application of a therapeutic agent to a patient, said device comprising: delivery means adapted to deliver a preselected therapeutic agent to a patient and having a controllable element for controlling therapeutic agent flow from said delivery means; and electronic means for controlling said controllable element and including a pre-programmed removable logic cartridge means providing sole operative memory for said device with said logic cartridge means being substantially operationally non-volatile to thereby provide programmable means in a format capable of implementing complex flow profiles of substantial duration for said delivery means when said programmable means is operatively positioned at said device.

Claim 2

Independent Claim 104 words

A device for effecting application of a therapeutic agent to a patient, said device comprising: delivery means adapted to deliver a preselected therapeutic agent to a patient and having a controllable element for controlling therapeutic agent flow from said delivery means; and electronic means for controlling said controllable element and including a pre-programmed removable logic cartridge means providing sole operative memory for said device with said logic cartridge means being substantially operationally non-volatile to thereby provide programmable means in a format capable of implementing complex flow profiles of substantial duration for said delivery means when said programmable means is operatively positioned at said device.

Claim 3

Dependent Claim 24 words

The device of claim 1 wherein said delivery means includes a syringe, and wherein said controllable element includes a driver for driving said syringe.

Claim 4

Dependent Claim 58 words

The device of claim 1 wherein said delivery means has a plurality of channels for separately conveying therapeutic agent therethrough, wherein said controllable element includes a controllable unit each of which is associated with a different one of said channels, and wherein said programmable means is pre-programmed to effect a separate flow profile for each of said channels.

Claim 5

Independent Claim 119 words

A device for effecting application of a therapeutic agent to a patient, said device comprising: drive means for controlling delivery of a preselected therapeutic agent to a patient; electronic means including a removable programmable logic cartridge means providing sole operative memory for said drive means with said logic cartridge means being substantially operationally non-volatile to thereby provide programmable means in a format capable of implementing complex flow profiles of substantial duration to control operation of said drive means when said programmable logic cartridge is programmed and operatively positioned; and computer means for receiving said removable programmable logic cartridge and programming the same with a then selected flow profile based upon predetermined parameters of patient need and therapeutic agent capabilities.

Claim 6

Independent Claim 119 words

A device for effecting application of a therapeutic agent to a patient, said device comprising: drive means for controlling delivery of a preselected therapeutic agent to a patient; electronic means including a removable programmable logic cartridge means providing sole operative memory for said drive means with said logic cartridge means being substantially operationally non-volatile to thereby provide programmable means in a format capable of implementing complex flow profiles of substantial duration to control operation of said drive means when said programmable logic cartridge is programmed and operatively positioned; and computer means for receiving said removable programmable logic cartridge and programming the same with a then selected flow profile based upon predetermined parameters of patient need and therapeutic agent capabilities.

Claim 7

Dependent Claim 41 words

The device of claim 4 wherein said programmable logic cartridge is selected from one of a programmable read-only-memory, an erasable programmable read-only-memory, an electrically erasable read-only-memory, an electrically alterable read-only-programmable memory, a non-volatile random access memory, and a programmable logic array.

Claim 8

Dependent Claim 13 words

The device of claim 4 wherein said computer means is a general-purpose computer.

Claim 9

Dependent Claim 69 words

The device of claim 4 wherein said device has a plurality of channels for separately delivering therapeutic agent to a patient, and wherein said drive means includes a driver associated with each of said channels, with each of said drivers being controlled by said programmable logic cartridge, and with said programmable logic cartridge being programmed by said computer to effect a separate flow profile for each of said channels.

Claim 10

Independent Claim 175 words

A device for effecting application of a therapeutic agent to a patient, said device comprising: application means including delivery means adapted to deliver a preselected therapeutic agent to a patient with said delivery means having a controllable element for controlling the flow of said therapeutic agent from said delivery means, and said application means also including electronic means for controlling said controllable element with said electronic means including a removable logic cartridge means providing sole operative memory for said application means with said logic cartridge means being substantially operationally non-volatile to thereby provide programmable means in a format capable of implementing complex flow profiles of substantial duration for said delivery means when said programmable means is programmed and operatively positioned at said application means; and programming means operationally independent of said application means for programming a then selected flow profile into said programmable means while said programmable means is removed from said application means to thereby enhance the integrity of said then selected flow profile during subsequent use while operatively positioned at said application means.

Claim 11

Independent Claim 175 words

A device for effecting application of a therapeutic agent to a patient, said device comprising: application means including delivery means adapted to deliver a preselected therapeutic agent to a patient with said delivery means having a controllable element for controlling the flow of said therapeutic agent from said delivery means, and said application means also including electronic means for controlling said controllable element with said electronic means including a removable logic cartridge means providing sole operative memory for said application means with said logic cartridge means being substantially operationally non-volatile to thereby provide programmable means in a format capable of implementing complex flow profiles of substantial duration for said delivery means when said programmable means is programmed and operatively positioned at said application means; and programming means operationally independent of said application means for programming a then selected flow profile into said programmable means while said programmable means is removed from said application means to thereby enhance the integrity of said then selected flow profile during subsequent use while operatively positioned at said application means.

Claim 12

Dependent Claim 24 words

The device of claim 8 wherein said application means includes a syringe, and wherein said controllable element includes a driver for driving said syringe.

Claim 13

Dependent Claim 14 words

The device of claim 8 wherein said logic cartridge is a read-only-memory type device.

Claim 14

Dependent Claim 39 words

The device of claim 8 wherein said logic cartridge is one of a programmable read-only-memory, an erasable programmable read-only-memory, an electrically erasable programmable read-only-memory, an electrically alterable progranable read-only-memory, a non-volatile random access memory and a programmable logic array.

Claim 15

Dependent Claim 13 words

The device of claim 8 wherein said programming means is a general-purpose computer.

Claim 16

Dependent Claim 45 words

The device of claim 12 wherein said device includes program means connected with said computer to provide data-base and assistive programs so that said computer is responsive to patient and drug information, as well as protocol and unit definition information when programming said programmable means.

Claim 17

Dependent Claim 38 words

The device of claim 8 wherein said programmable means is programmed by said programming means to cause said flow through said delivery means to deliver said therapeutic agent by one of a time-based and an event-synchronized flow profile.

Claim 18

Dependent Claim 28 words

The device of claim 14 wherein said therapeutic agent is one of physical matter and energy, and wherein said flow profile controls delivery of said selected therapeutic agent.

Claim 19

Dependent Claim 85 words

The device of claim 8 wherein said delivery means includes channel means defining a plurality of channels for separately delivering therapeutic agent, wherein said controllable element includes a plurality of controllable units each of which is associated with a different one of said channels, wherein said programable means controls each of said controllable units, and wherein said programming means programs said programmable means so that each of said units operates independently of one another whereby independent flow profiles are established for each of said channels.

Claim 20

Dependent Claim 30 words

The device of claim 8 wherein said application means includes a controller and memory means connected with said controller for recording the history of therapeutic agent flow from said device.

Claim 21

Independent Claim 104 words

A method for effecting application of a therapeutic agent to a patient, said method comprising: providing delivery means adapted to deliver a preselected therapeutic agent to a patient; controlling operation of said delivery means through electronic means that includes a removable logic cartridge that provides sole operative memory for said application means with said logic cartridge being substantially operationally non-volatile to thereby provide a programmable element in a format capable of implementing complex profiles of substantial duration so that so programmable element, when operatively positioned, establishes the flow profile of said delivery means; and pre-programming said programmable element while removed from said application means.

Claim 22

Independent Claim 104 words

A method for effecting application of a therapeutic agent to a patient, said method comprising: providing delivery means adapted to deliver a preselected therapeutic agent to a patient; controlling operation of said delivery means through electronic means that includes a removable logic cartridge that provides sole operative memory for said application means with said logic cartridge being substantially operationally non-volatile to thereby provide a programmable element in a format capable of implementing complex profiles of substantial duration so that so programmable element, when operatively positioned, establishes the flow profile of said delivery means; and pre-programming said programmable element while removed from said application means.

Claim 23

Dependent Claim 28 words

The method of claim 18 wherein said method includes providing a syringe and a driver for driving said syringe in order to deliver therapeutic agent to said patient.

Claim 24

Dependent Claim 25 words

The method of claim 18 wherein said method includes programming said logic cartridge while removed from said delivery means by use of a general-purpose computer.

Claim 25

Dependent Claim 62 words

The method of claim 18 wherein said method includes providing a delivery means having a plurality of channels through which therapeutic agents are separately conveyed for delivery to a patient and separately controlling the flow of therapeutic agent through each of channels by said programmable element by pre-programming said programmable element to establish a separate flow profile for each of said channels.

Claim 26

Independent Claim 109 words

A method for effecting application of a therapeutic agent to a patient, said method comprising: determining the parameters of flow for a preselected therapeutic agent with respect to a predetermined patient; programming a logic cartridge that provides sole operative memory for said application of said therapeutic agent with said logic cartridge being substantially operationally non-volatile to thereby provided a programmable element in a format capable of implementing complex profiles of substantial duration so that said programmable element establishes a flow profile according to the determined parameters of flow for said preselected therapeutic agent; and using said programmable element to control flow of said predetermined therapeutic agent to said patient.

Claim 27

Independent Claim 109 words

A method for effecting application of a therapeutic agent to a patient, said method comprising: determining the parameters of flow for a preselected therapeutic agent with respect to a predetermined patient; programming a logic cartridge that provides sole operative memory for said application of said therapeutic agent with said logic cartridge being substantially operationally non-volatile to thereby provided a programmable element in a format capable of implementing complex profiles of substantial duration so that said programmable element establishes a flow profile according to the determined parameters of flow for said preselected therapeutic agent; and using said programmable element to control flow of said predetermined therapeutic agent to said patient.

Claim 28

Dependent Claim 66 words

The method of claim 22 wherein said method includes determining the parameters of flow for a plurality of preselected therapeutic agents with respect to a predetermined patient, programming said programmable element with a flow profile according to the determined parameters of flow for each of said preselected therapeutic agents, and using said programmable element to separately control flow of said preselected therapeutic agents to said patient.

Claim 29

Dependent Claim 17 words

The method of claim 22 wherein said method includes using a computer to determine said flow parameters.

Claim 30

Dependent Claim 20 words

The method of claim 24 wherein user needs and patient history are utilized in said computer to determine said parameters.

Claim 31

Dependent Claim 37 words

The method of claim 25 wherein said flow profile is established based upon the toxic threshold of said patient at preselected times of the day to thereby enhance the effectiveness of therapeutic agent delivery to said patient.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1990-06-29	1990-12-29	1991-06-30	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1994-06-29	1994-12-29	1995-06-30	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1998-06-29	1998-12-29	1999-06-30	$7700.00	Window Closed / Lapsed

Device and method for effecting application of a therapeutic agent

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