Patent US4652459A successfully refreshed from Google Patents.
US4652459A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implants, and process for the production thereof
Assignee: Individual
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Filing: 1985-07-31
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Granted: 1987-03-24
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Expires: 2005-07-31
Abstract
Abstract An improved implant is disclosed, having a customary substrate, particularly at least partially of metal, and a one- or multi-layer coating of ceramic, biologically compatible glasses and/or bioactive glasses, the improvement comprising a second type layer covalently bound on said coating of ceramic or bioglass said second type of layer being from polymeric organo-silicon compounds, and said second type of layer being covalently coupled, with or without a coupling molecule, with a third type of layer of a synthetic or natural biopolymer. Also disclosed is a process for producing the implant, by applying in known mariner a coating of ceramic, biologically compatible and/or bioactive glasses onto a substrate of said implant, providing said coating with a second type of layer of polymerized organo-silicon compound (polysiloxane) in covalent connection therewith, and coupling said second type of layer with a third type of layer of a synthetic or natural biopolymer, with or without use of a coupling means.
Inventors
- 👤 Achim Engelhardt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:22
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/025; A61L27/28; A61L27/34; Y; Y10; Y10S; Y10S128/00; Y10S128/21
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
67 words
Process for production of an implant, comprising applying a coating of ceramic, biologically compatible or bioactive glasses onto a substrate composed at least partially of metal, applying onto said coating a second type of layer of polymerized organo-silicon compound (polysiloxane) in covalent connection therewith, and applying onto said second type of layer a third type of layer of a synthetic or natural bipolymer in covalent connection therewith.
Claim 2
Dependent Claim
67 words
Process for production of an implant, comprising applying a coating of ceramic, biologically compatible or bioactive glasses onto a substrate composed at least partially of metal, applying onto said coating a second type of layer of polymerized organo-silicon compound (polysiloxane) in covalent connection therewith, and applying onto said second type of layer a third type of layer of a synthetic or natural bipolymer in covalent connection therewith.
Claim 3
Dependent Claim
111 words
Process according to claim 1, further comprising before said step of applying onto said coating a second type of layer, cleaning said coating in a dust-free and oxygen-free area with ultrafiltrated, de-gasified solutions of acetone, toluene, ethanol and doubly-distilled water, thereby providing a fat-free and dust-free surface, drying said fat-free and dust-free surface with a vapor stream of an organic solvent which forms with water an azeotropic mixture, oxidatively hydrolysing said dry surface with 1 to 3M nitric acid, washing said surface with dilute nitric acid and then with pure water, and acid hydrolysing said surface in a water bath at high temperature, followed by briefly washing said surface with water.
Claim 4
Dependent Claim
34 words
Process according to claim 1, wherein said third type of layer of a synthetic or natural biopolymer is applied onto said second type of layer in covalent connection with use of a coupling means.
Claim 5
Dependent Claim
16 words
Process according to claim 1, wherein a polypeptide is employed as said natural or synthetic biopolymer.
Claim 6
Dependent Claim
31 words
Process according to claim 1, wherein said coating of ceramic or glasses comprises a polished surface, and further comprising pre-etching said surface with hydrogen fluoride and then hydrolizing with pure water.
Claim 7
Dependent Claim
15 words
Process according to claim 5, using for said pre-etching 10% hydrogen fluoride at room temperature.
Claim 8
Dependent Claim
18 words
Process according to claim 2, wherein said oxidatively hydrolysing is performed for about three hours at room temperature.
Claim 9
Dependent Claim
40 words
Process according to claim 2, wherein said acid hydrolysing is performed at about 70° C. with an acid selected from the group consisting of ortho-phosphoric acid, acetic acid, perchloric acid and hydrochloric acid, at a strength from 1 to 3M.
Claim 10
Dependent Claim
43 words
Process according to claim 2, further comprising before said step of applying onto said coating a second type of layer and after said brief washing, further alkaline hydrolysing said surface with heated sodium lye or potassium lye, and then washing with double-distilled water.
Claim 11
Dependent Claim
17 words
Process according to claim 9, wherein said lye is employed at a concentration from 0.5 to 3M.
References Cited (Backward Citations)
US3808113A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-23 | 1990-09-22 | 1991-03-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-23 | 1994-09-22 | 1995-03-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-23 | 1998-09-22 | 1999-03-24 | $7700.00 | Window Closed / Lapsed |