US4648407A
Expired / Lapsed
US
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Method for detecting and differentiating central and obstructive apneas in newborns
Assignee: Non-Invasive Monitoring Systems Inc
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Filing: 1986-06-13
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Granted: 1987-03-10
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Expires: 2006-06-13
Abstract
Abstract The presence and origin of apnea in a newborn subject is detected by separately and concurrently monitoring relative movement of the cranial bones and nasal ventilation. The cranial bones have been found to move with respiration as a function of intrapleural pressure, and monitoring of their movement is accordingly used to generate a signal representative of intrapleural pressure. A nasal cannula, thermistor, thermocouple or CO 2 sensors are employed to concurrently generate a signal representative of tidal volume. Absence of changes in both cranial bone movement and respiratory air flow at the nose is indicative of the presence of central apnea, while absence of nasal air flow accompanied by continuing cranial bone movements is indicative of obstructive apnea. The preferred device for detecting cranial bone movement is a surface inductive plethysmographic transducer, although other suitably sensitive motion detecting devices may be employed.
Inventors
- 👤 Marvin A. Sackner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:00
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/48; A61B5/4806; A61B5/4818; A61B5/103; A61B5/11; A61B5/113; A61B5/45; A61B5/4504; A61B5/68; A61B5/6801; A61B5/6813; A61B5/6814
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
192 words
A method of detecting and differentiating between central and obstructive apneas in a newborn subject, comprising: mounting an external means for detecting movement across at least two adjacently-proximate cranial bones of the subject to detect relative movement between said bones; generating a first signal indicative of changes in the relative positions of said cranial bones detected by said means, changes in said first signal being indicative of changes in intrapleural pressure of the subject; disposing a means for non-invasively detecting variations in tidal breathing at the subject's nostrils; generating a second signal indicative of variations in tidal breathing detected by said last mentioned means, changes in said second signal being indicative of variations in nasal tidal volume of the subject; and continuously monitoring said first and second signals to detect the presence of and to differentiate between central and obstructive apneas in the subject, whereby a substantial absence of changes in both said first and second signals is indicative of the presence of central apnea, and a substantial absence of changes in said second signal when accompanied by continuing changes in said first signal is indicative of the presence of obstructive apnea.
Claim 2
Independent Claim
192 words
A method of detecting and differentiating between central and obstructive apneas in a newborn subject, comprising: mounting an external means for detecting movement across at least two adjacently-proximate cranial bones of the subject to detect relative movement between said bones; generating a first signal indicative of changes in the relative positions of said cranial bones detected by said means, changes in said first signal being indicative of changes in intrapleural pressure of the subject; disposing a means for non-invasively detecting variations in tidal breathing at the subject's nostrils; generating a second signal indicative of variations in tidal breathing detected by said last mentioned means, changes in said second signal being indicative of variations in nasal tidal volume of the subject; and continuously monitoring said first and second signals to detect the presence of and to differentiate between central and obstructive apneas in the subject, whereby a substantial absence of changes in both said first and second signals is indicative of the presence of central apnea, and a substantial absence of changes in said second signal when accompanied by continuing changes in said first signal is indicative of the presence of obstructive apnea.
Claim 3
Dependent Claim
50 words
The method according to claim 1, wherein said means mounting step comprises securing a deformable conductive loop across at least said two adjacently-proximate cranial bones of the subject for movement therewith, and said first signal generating step comprises generating a first signal indicative of changes of self-inductance of said loop.
Claim 4
Dependent Claim
42 words
The method according to claim 2, wherein said first signal generating step comprises incorporating said loop as the inductance in a variable frequency LC oscillator for converting changes in said self-inductance to corresponding changes in the frequency of the oscillator output signal.
Claim 5
Dependent Claim
28 words
The method according to claim 3, further comprising the step of converting changes in the frequency of said LC oscillator output signal to corresponding changes in signal amplitude.
Claim 6
Dependent Claim
26 words
The method according to claim 1, further comprising the step of calibrating said first signal to provide a measurement of actual intrapleural pressure of the subject.
Claim 7
Dependent Claim
26 words
The method according to claim 3, further comprising the step of calibrating said first signal to provide a measurement of actual intrapleural pressure of the subject.
Claim 8
Dependent Claim
58 words
The method according to claim 5, wherein said calibrating step comprises: momentarily manually occluding the nose of the subject; measuring the subject's airway pressure while the nose is occluded; adjusting said first signal to equal said airway pressure measured with the nose occluded; and removing the occlusion of the subject's nose to enable the resumption of natural breathing.
Claim 9
Dependent Claim
58 words
The method according to claim 6, wherein said calibrating step comprises: momentarily manually occluding the nose of the subject; measuring the subject's airway pressure while the nose is occluded; adjusting said first signal to equal said airway pressure measured with the nose occluded; and removing the occlusion of the subject's nose to enable the resumption of natural breathing.
Claim 10
Dependent Claim
73 words
The method according to claim 5 wherein the newborn subject is intubated with an endotracheal tube, said calibrating step comprising: momentarily manually occluding the endotracheal tube; measuring the subject's airway pressure while the endotracheal tube is occluded and an inspiratory effort is made; adjusting said first signal to equal said airway pressure measured with the endotracheal tube occluded; and removing the occlusion of the endotracheal tube to enable the resumption of natural breathing.
Claim 11
Dependent Claim
73 words
The method according to claim 6 wherein the newborn subject is intubated with an endotracheal tube, said calibrating step comprising: momentarily manually occluding the endotracheal tube; measuring the subject's airway pressure while the endotracheal tube is occluded and an inspiratory effort is made; adjusting said first signal to equal said airway pressure measured with the endotracheal tube occluded; and removing the occlusion of the endotracheal tube to enable the resumption of natural breathing.
Claim 12
Dependent Claim
30 words
The method according to claim 1, wherein said means mounting step comprises securing said movement detecting means across the frontal fontanel of the subject to detect relative cranial bone movement.
Claim 13
Dependent Claim
30 words
The method according to claim 1, wherein said means mounting step comprises securing said movement detecting means across the occipital fontanel of the subject to detect relative cranial bone movement.
Claim 14
Dependent Claim
32 words
The method according to claim 1, wherein said means mounting step comprises securing said movement detecting means across the sagittal suture of the subject to detect relative movement between the parietal bones.
Claim 15
Dependent Claim
55 words
The method according to claim 1, wherein said means disposing step comprises securing a nasal cannula on the subject so that a portion of the cannula projects partially into the nostrils, and wherein said second signal generating step comprises connecting said cannula to a pressure transducer to generate an output indicative of tidal breathing pressure.
Claim 16
Dependent Claim
22 words
The method according to claim 14, wherein the output of the pressure transducer has a signal amplitude representative of tidal breathing volume.
Claim 17
Dependent Claim
27 words
The method according to claim 1, further comprising the step of calibrating said second signal to provide a measurement of actual tidal breathing volume of the subject.
Claim 18
Dependent Claim
27 words
The method according to claim 15, further comprising the step of calibrating said second signal to provide a measurement of actual tidal breathing volume of the subject.
Claim 19
Dependent Claim
41 words
The method according to claim 16, wherein said calibrating step comprises: measuring nasal tidal volume of the subject using an external volume measuring means; and adjusting said second signal to equal said nasal tidal volume measured with said volume measurement means.
Claim 20
Dependent Claim
41 words
The method according to claim 17, wherein said calibrating step comprises: measuring nasal tidal volume of the subject using an external volume measuring means; and adjusting said second signal to equal said nasal tidal volume measured with said volume measurement means.
Claim 21
Dependent Claim
78 words
The method according to claim 1, further comprising the steps of: observing the value of said second signal during natural respiration of the subject to establish a control value of said second signal corresponding to relative tidal volume of the subject during natural respiration; and observing the value of said first signal during natural respiration of the subject to establish a control value of said first signal corresponding to relative intrapleural pressure of the subject during natural respiration.
Claim 22
Dependent Claim
170 words
The method according to claim 20, said monitoring step comprising continuously comparing said first and second signals to said control values thereof, and generating an alarm when either one or both of said first and second signals decreases by at least a predetermined amount from its respective control value or there exists a substantial absence of changes in one or both of said first and second signals, whereby a substantial absence of changes in both said first and second signals is indicative of the presence of central apnea, a substantial absence of changes in said second signal when accompanied by continuing changes in said first signal, is indicative of the presence of obstructive apnea, a substantial decrease from the control value of both said first and second signals is suggestive of the presence of central hypopnea, and a substantial decrease from the control value of said second signal when unaccompanied by a substantial decrease from the control value of said first signal is suggestive of the presence of obstructive hypopnea.
Claim 23
Dependent Claim
32 words
The method according to claim 21, said alarm generating step comprising generating a distinct alarm for each of said enumerated conditions indicative of central apnea, obstructive apnea, central hypopnea and obstructive hypopnea.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-03-09 | 1990-09-08 | 1991-03-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-09 | 1994-09-08 | 1995-03-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-09 | 1998-09-08 | 1999-03-10 | $7700.00 | Window Closed / Lapsed |