Patent US4647283A successfully refreshed from Google Patents.
US4647283A
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US
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Implantable biological tissue and process for preparation thereof
Assignee: Edwards Lifesciences Corp
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Filing: 1984-11-13
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Granted: 1987-03-03
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Expires: 2004-11-13
Abstract
Abstract A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification of the implanted tissue.
Inventors
- 👤 Alain Carpentier
- 👤 Sophie Carpentier
- 👤 Aws S. Nashef
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:52
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2412; A61L2400/00; A61L2400/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/918; Y10S623/92; Y10S623/922
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
97 words
A process for treating biological tissue prior to implantation which comprises the steps of: a. fixing said tissue under tissue fixing conditions; b. contacting said fixed tissue with a solution effective in reducing calcification of said tissue after implantation; said calcification reducing solution comprising an amount of a calcium-binding competing divalent cation effective in reducing calcification and having a level of phosphate decreased to an amount effective in reducing calcification of tissue after implantation; and c. maintaining the tissue in contact with a solution having said reduced level of phosphate to a time just prior to implantation.
Claim 2
Dependent Claim
97 words
A process for treating biological tissue prior to implantation which comprises the steps of: a. fixing said tissue under tissue fixing conditions; b. contacting said fixed tissue with a solution effective in reducing calcification of said tissue after implantation; said calcification reducing solution comprising an amount of a calcium-binding competing divalent cation effective in reducing calcification and having a level of phosphate decreased to an amount effective in reducing calcification of tissue after implantation; and c. maintaining the tissue in contact with a solution having said reduced level of phosphate to a time just prior to implantation.
Claim 3
Independent Claim
98 words
A method of increasing the durability of implantable biological tissue which comprises the steps of: a. fixing said tissue under tissue fixing conditions; b. contacting said fixed tissue with a solution effective in reducing calcification of said tissue after implantation; said calcification reducing solution comprising an amount of a calcium-binding competing divalent cation effective in reducing calcification and having a level of phosphate decreased to an amount effective in reducing calcification of tissue after implantation; and c. maintaining the tissue in contact with a solution having said reduced level of phosphate to a time just prior to implantation.
Claim 4
Independent Claim
98 words
A method of increasing the durability of implantable biological tissue which comprises the steps of: a. fixing said tissue under tissue fixing conditions; b. contacting said fixed tissue with a solution effective in reducing calcification of said tissue after implantation; said calcification reducing solution comprising an amount of a calcium-binding competing divalent cation effective in reducing calcification and having a level of phosphate decreased to an amount effective in reducing calcification of tissue after implantation; and c. maintaining the tissue in contact with a solution having said reduced level of phosphate to a time just prior to implantation.
Claim 5
Dependent Claim
16 words
The process of claim 1 wherein the divalent cation is a magnesium ion or salt thereof.
Claim 6
Dependent Claim
26 words
The process of claim 3 wherein the magnesium salt is selected from the group consisting of MgCl 2 , MgSO 4 , and MgCO 3 .
Claim 7
Dependent Claim
12 words
The process of claim 3 wherein the magnesium salt is magnesium chloride.
Claim 8
Dependent Claim
21 words
The process of claim 1 wherein the tissue is treated with an amount of divalent cation sufficient to saturate the tissue.
Claim 9
Dependent Claim
18 words
The process of claim 1 wherein the biological tissue is used in the preparation of a heart valve.
Claim 10
Dependent Claim
28 words
The process of claim 5 wherein the tissue is used in the preparation of a heart valve and the concentration of magnesium chloride is about 0.26 weight percent.
Claim 11
Dependent Claim
16 words
The method of claim 2 wherein the divalent cation is a magnesium ion or salt thereof.
Claim 12
Dependent Claim
26 words
The method of claim 9 wherein the magnesium salt is selected from the group consisting of MgCl 2 , MgSO 4 , and MgCO 3 .
Claim 13
Dependent Claim
12 words
The method of claim 9 wherein the magnesium salt is magnesium chloride.
Claim 14
Dependent Claim
21 words
The method of claim 2 wherein the tissue is treated with an amount of divalent cation sufficient to saturate the tissue.
Claim 15
Dependent Claim
18 words
The method of claim 2 wherein the biological tissue is used in the preparation of a heart valve.
Claim 16
Dependent Claim
28 words
The method of claim 11 wherein the tissue is used in the preparation of a heart valve and the concentration of magnesium chloride is about 0.26 weight percent.
References Cited (Backward Citations)
US4378224A
Cited
US4481009A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-02 | 1990-09-01 | 1991-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-02 | 1994-09-01 | 1995-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-02 | 1998-09-01 | 1999-03-03 | $7700.00 | Window Closed / Lapsed |