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US4634604A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for producing a biocompatible layer on the surface of particles of porous synthetic sorbents

Assignee: Czech Academy of Sciences
•
Filing: 1984-06-20
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Granted: 1987-01-06
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Expires: 2004-06-20
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Abstract

Abstract The invention pertains to the method for producing a biocompatible layer on the surface of particles of porous synthetic sorbents. An object of the invention consists in the method for producing a biocompatible layer on the surface of particles of porous synthetic sorbents by action of a solution of biocompatible polymer of acrylate or methacrylate type, or of its monomer in the presence of polymerization initiators, on a suspension of sorbent, which is agitated with steam. The method according to the invention renders a material, the sorption capacity of which is entirely retained. This is due to water, which remains enclosed in the pores of sorbent and enables the sorption of toxins also inside the gel particles. In addition, steam can be prepared completely apyrogenic and thus to secure that the sorbents remain clean inside. Clinical tests reveal that the sorbents coated by the method according to the invention have an excellent hemocompatibility.

Inventors

  • 👤 Marie Tlustakova
  • 👤 Jiri Horak
  • 👤 Josef Vavrouch
  • 👤 Jiri Kulisek
  • 👤 Jaroslav Kalal

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 19:47
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/261; B01J20/264; B01J20/265; B01J20/267; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28014; B01J20/28047; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3206; B01J20/3208; B01J20/321; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/327; B01J20/3276; B01J20/328; B01J20/3282; B01J2220/00; B01J2220/50; B01J2220/58; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985; Y10T428/2987; Y10T428/2991; Y10T428/2998

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 74 words
Method for producing a biocompatible layer on the surface of particles of porous synthetic sorbents, wherein a solution of biocompatible polymer of the acrylate or methacrylate type, or its monomer in the presence of polymerization initiators, acts on a suspension of the sorbent, which is stirred by steam, said biocompatible polymer forming on the surface of said particles as a thin coherent layer, such that the resulting coated particles retain their initial sorption capacity.
Claim 2
Dependent Claim 74 words
Method for producing a biocompatible layer on the surface of particles of porous synthetic sorbents, wherein a solution of biocompatible polymer of the acrylate or methacrylate type, or its monomer in the presence of polymerization initiators, acts on a suspension of the sorbent, which is stirred by steam, said biocompatible polymer forming on the surface of said particles as a thin coherent layer, such that the resulting coated particles retain their initial sorption capacity.
Claim 3
Dependent Claim 34 words
The method according to claim 1, wherein an alcohol with 1 to 2 carbon atoms, or its mixture with water or aqueous solutions of salts, is used as a solvent of the biocompatible polymer.
Claim 4
Dependent Claim 13 words
The method according to claim 1, wherein the biocompatible polymer is poly(2-hydroxyethyl methacrylate).
Claim 5
Dependent Claim 14 words
The method according to claim 1, wherein the biocompatible polymer is crosslinked poly(2-hydroxyethyl methacrylate).
Claim 6
Dependent Claim 23 words
The method according to claim 1, wherein 2-hydroxyethyl methacrylate as such or in the presence of ethylen dimethacrylate is used as the monomer.
Claim 7
Dependent Claim 20 words
The method according to claim 1, wherein water-soluble initiators of radical polymerization are used to initiate the polymerization of monomer.

References Cited (Backward Citations)

US3576760A Cited
US4187194A Cited
US3787522A Cited
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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1990-01-05 1990-07-07 1991-01-06 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1994-01-05 1994-07-07 1995-01-06 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1998-01-05 1998-07-07 1999-01-06 $7700.00 Window Closed / Lapsed

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