Patent US4596574A successfully refreshed from Google Patents.
US4596574A
Expired / Lapsed
US
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Biodegradable porous ceramic delivery system for bone morphogenetic protein
Assignee: University of California
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Filing: 1984-05-14
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Granted: 1986-06-24
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Expires: 2004-05-14
Abstract
Abstract Disclosed is a biodegradable porous ceramic delivery system useful for delivery of bone morphogenic protein (BMP) to viable tissue and to induce formation of new bone therein. The delivery composite is substantially pure BMP in combination with a biodegradable porous ceramic (sintered), e.g. beta-tricalcium phosphate, and may be prepared by admixing the BMP with the porous ceramic material. The composition is implanted in viable tissue where the BMP is slowly released and induces formation of new bone.
Inventors
- 👤 Marshall R. Urist
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:51
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2009; A61L27/02; A61L27/12; A61L27/40; A61L27/44; A61L27/46; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
14 words
A composition comprising a physiologically acceptable, biodegradable porous ceramic containing bone morphogenic protein (BMP).
Claim 2
Dependent Claim
14 words
A composition comprising a physiologically acceptable, biodegradable porous ceramic containing bone morphogenic protein (BMP).
Claim 3
Dependent Claim
51 words
A composition according to claim 1, wherein the physiologically acceptable, biodegradable porous ceramic is composed of a salt having a cation selected from the group consisting of physiologically acceptable alkali metals, alkaline earth metals, and transition metals and an anion selected from the group consisting of phosphate, sulfate, carbonate and silicate.
Claim 4
Dependent Claim
17 words
A composition according to claim 2, wherein the porous ceramic has a sintered, vitreous or glass-like form.
Claim 5
Dependent Claim
31 words
A composition according to claim 3, wherein the cation is selected from the group consisting of sodium, potasium, calcium, magnesium, manganese, vandium, iron, copper, zinc, silver, gold, aluminum, cobalt and platinum.
Claim 6
Dependent Claim
21 words
A composition according to claim 1, wherein the physiologically acceptable, biodegradable porous ceramic is a sintered mass of tricalcium phosphate (TCP).
Claim 7
Dependent Claim
22 words
A composition according to claim 1, wherein the physiologically acceptable, biodegradable porous ceramic is a sintered mass of beta tricalcium phosphate (BTCP).
Claim 8
Independent Claim
32 words
A system for delivering bone morphogenic protein (BMP) to viable tissue and inducing formation of new bone therein, comprising: a physiologically acceptable, biodegradable porous ceramic containing substantially pure bone morphogenic protein (BMP).
Claim 9
Independent Claim
32 words
A system for delivering bone morphogenic protein (BMP) to viable tissue and inducing formation of new bone therein, comprising: a physiologically acceptable, biodegradable porous ceramic containing substantially pure bone morphogenic protein (BMP).
Claim 10
Dependent Claim
17 words
A delivery system according to claim 7, wherein the ceramic is sintered, porous beta tricalcium phosphate (BTCP).
Claim 11
Dependent Claim
31 words
The delivery system according to claim 8, wherein the weight ratio of BMP to sintered porous BTCP is at least about 1 part BMP to about 100 parts sintered porous BTCP.
Claim 12
Dependent Claim
21 words
A delivery system according to claim 9, wherein the sintered porous beta tricalcium (BTCP) has a Ca/P ratio of about 1.5.
Claim 13
Dependent Claim
29 words
A delivery system according to claim 10, wherein the weight ratio is in the range of about 1 part bone morphogenic protein (BMP) to 19 parts sintered porous BTCP.
Claim 14
Dependent Claim
22 words
A delivery system according to claim 9, wherein the sintered porous beta tricalcium phosphate (BTCP) has a Ca/P ratio of about 1.66.
Claim 15
Dependent Claim
16 words
A delivery system acocrding to claim 7, further comprising a radioopacifying agent contained in said ceramic.
Claim 16
Dependent Claim
15 words
A delivery system according to claim 7, further comprising an antibiotic contained in said ceramic.
Claim 17
Dependent Claim
18 words
An artificial appliance comprising a prosthesis bone device in combination with a delivery system according to claim 7.
Claim 18
Independent Claim
48 words
A method for inducing formation of new bone in viable tissue, comprising: implanting in said viable tissue a delivery system of a physiologically acceptable, biodegradable porous ceramic containing substantially pure BMP wherein the weight ratio is at least about 1 part BMP to about 100 parts porous ceramic.
Claim 19
Independent Claim
48 words
A method for inducing formation of new bone in viable tissue, comprising: implanting in said viable tissue a delivery system of a physiologically acceptable, biodegradable porous ceramic containing substantially pure BMP wherein the weight ratio is at least about 1 part BMP to about 100 parts porous ceramic.
Claim 20
Independent Claim
57 words
A method for preparing a delivery system composite for delivering bone morphogenic protein (BMP) to viable tissue and inducing formation of new bone therein, comprising: contacting a physiologically acceptable, biodegradable porous ceramic with a liquid containing substantially pure BMP and removing said liquid therefrom so that an effective amount of BMP is entrapped in the porous ceramic.
Claim 21
Independent Claim
57 words
A method for preparing a delivery system composite for delivering bone morphogenic protein (BMP) to viable tissue and inducing formation of new bone therein, comprising: contacting a physiologically acceptable, biodegradable porous ceramic with a liquid containing substantially pure BMP and removing said liquid therefrom so that an effective amount of BMP is entrapped in the porous ceramic.
Claim 22
Dependent Claim
55 words
A method according to claim 17, wherein the porous ceramic is composed of a salt having a cation selected from the group consisting of a physiologically acceptable alkali metal, a physiologically acceptable alkaline earth metal, and a physiologically acceptable transition metal; and an anion selected from the group consisting of phosphate, sulfate, carbonate and silicate.
Claim 23
Dependent Claim
31 words
The method according to claim 18, wherein the cation is selected from the group consisting of sodium, potasium, calcium, magnesium, manganese, vanadium, iron, copper, zinc, silver, gold, aluminum, colbalt, and platinum.
Claim 24
Dependent Claim
16 words
A method according to claim 17, wherein the porous ceramic is a sintered mass of TCP.
Claim 25
Dependent Claim
23 words
A method according to claim 20, wherein the sintered mass is beta tricalcium phosphate (BTCP) which has a Ca/P ratio of about 1.5.
Claim 26
Dependent Claim
23 words
A method according to claim 21 wherein the weight ratio is in the range of about 1 part BMP to 19 parts BTCP.
Claim 27
Dependent Claim
18 words
A method according to claim 22 wherein the delivery system, further comprises an antibiotic contained in said ceramic.
Claim 28
Dependent Claim
20 words
The method according to claim 22 wherein the delivery system composite, further comprises a radioopacifying agent contained in said ceramic.
Claim 29
Independent Claim
37 words
A method for preparing a prosthesis for implanting, which comprises: providing a bone morphogenic protein (BMP) delivery system of a physiologically acceptable, biodegradable porous ceramic containing substantially pure BMP on at least a portion of the prosthesis.
Claim 30
Independent Claim
37 words
A method for preparing a prosthesis for implanting, which comprises: providing a bone morphogenic protein (BMP) delivery system of a physiologically acceptable, biodegradable porous ceramic containing substantially pure BMP on at least a portion of the prosthesis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-23 | 1989-12-23 | 1990-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-23 | 1993-12-23 | 1994-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-23 | 1997-12-23 | 1998-06-24 | $7700.00 | Window Closed / Lapsed |