Patent US4569836A successfully refreshed from Google Patents.
US4569836A
Expired / Lapsed
US
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Cancer treatment by intracellular hyperthermia
Assignee: GORDON DAVID SKOKIE ILLINOIS
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Filing: 1983-05-24
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Granted: 1986-02-11
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Expires: 2003-05-24
Abstract
Abstract A treatment of cancer by the application of chemical reactions intracellularly capable of the intracellular generation of heat so as to induce selective thermal death of cancer cells in living tissue. Metabolizable minute particles of a size less than one micron are intravenously injected into the patient and absorbed by the cancer cells. The oxygen level of the patient's blood is then increased. The rate of intracellular chemical reaction in the cancer cells due at least in part to the intracellular presence of these minute particles is thereby increased and intracellular heat generated. The oxygen level is increased until the intracellular temperature has increased at least 8.0 degrees Centigrade but not more than 9.5 degrees Centigrade thereby selectively killing the cancer cells without damaging the normal cells.
Inventors
- 👤 Robert T. Gordon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:58
CPC Classifications
A; A61; A61K; A61K41/00; A61K41/0052; A61F; A61F7/00; A61K51/00; A61K51/12; A61K51/1258; A61F2007/0089; A61K2121/00
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
147 words
A process for the treatment of cancer cells in living tissue of a patient comprising the following steps: introducing into the living tissue of the patient minute particles of a size not greater than one micron and capable of being metabolized by the cancer cells and capable of an increased rate of metabolism or oxidation by the increased availability of oxygen, absorbing said minute particles intracellularly into the cancer cells, thereafter, increasing the oxygen level of the blood of the patient, and thereby increasing the rate of intracellular chemical reaction in the cancer cells due at least in part to the intracellular presence of said minute particles, and generating intracellular heat therein, and continuing said increasing the oxygen level step until the intracellular temperature has increased at least 8.0 degrees Centigrade but not more than 9.5 degrees Centigrade to selectively induce thermal death of the cancer cells.
Claim 2
Dependent Claim
147 words
A process for the treatment of cancer cells in living tissue of a patient comprising the following steps: introducing into the living tissue of the patient minute particles of a size not greater than one micron and capable of being metabolized by the cancer cells and capable of an increased rate of metabolism or oxidation by the increased availability of oxygen, absorbing said minute particles intracellularly into the cancer cells, thereafter, increasing the oxygen level of the blood of the patient, and thereby increasing the rate of intracellular chemical reaction in the cancer cells due at least in part to the intracellular presence of said minute particles, and generating intracellular heat therein, and continuing said increasing the oxygen level step until the intracellular temperature has increased at least 8.0 degrees Centigrade but not more than 9.5 degrees Centigrade to selectively induce thermal death of the cancer cells.
Claim 3
Dependent Claim
19 words
The process of claim 1 including, said increasing the oxygen level step including subjecting the patient to hyperbaric air.
Claim 4
Dependent Claim
19 words
The process of claim 1 including, said increasing the oxygen level step including subjecting the patient to hyperbaric oxygen.
Claim 5
Dependent Claim
39 words
The process of claim 1 including, said increasing the oxygen level step including increasing the levels of 2,3-Diphosphoglycerate in the body to enhance the availability of the oxygen to the cells and thereby increasing the metabolism in the cells.
Claim 6
Dependent Claim
32 words
The process of claim 1 including, said increasing the oxygen level step including introducing phosphates into the patient to increase the availability of oxygen to the cells and thereby increasing intracellular metabolism.
Claim 7
Dependent Claim
19 words
The process of claim 5 including, said increasing the oxygen level step including subjecting the patient to hyperbaric oxygen.
Claim 8
Dependent Claim
17 words
The process of claim 1 including, said minute particles comprising a compound which can be further oxidized.
Claim 9
Dependent Claim
18 words
The process of claim 7 including, said compound being ferric oxyhydroxide, ferric hydroxide, iron carbonate, or iron citrate.
Claim 10
Dependent Claim
18 words
The process of claim 1 including, said introducing step including intravenously injecting into the patient said minute particles.
Claim 11
Dependent Claim
23 words
The process of claim 1 including, said introducing step including intravenously injecting into the patient said minute particles suspended in a liquid vehicle.
Claim 12
Dependent Claim
15 words
The process of claim 10 including, said minute particles being integrated with a sugar molecule.
Claim 13
Dependent Claim
15 words
the process of claim 11 including, said sugar molecule being dextrose, dextran, glucose or sucrose.
Claim 14
Dependent Claim
13 words
The process of claim 1 including, said minute particles being bound to radioisotopes.
Claim 15
Dependent Claim
14 words
The process of claim 1 including, said minute particles being bound to cancer antibodies.
Claim 16
Dependent Claim
15 words
The process of claim 1 including, said minute particles comprising minute encapsulated chemotherapeutic agent particles.
Claim 17
Dependent Claim
15 words
The process of claim 1 including, said minute particles comprising minute integrated chemotherapeutic agent particles.
Claim 18
Dependent Claim
25 words
The process of claim 1 including, said minute particles comprising radioisotopes, and said absorbing step including said radioisotopes being absorbed selectively in said cancer cells.
Claim 19
Dependent Claim
15 words
The process of claim 17 including, said radioisotopes being gallium-67, indium-113m, technetium-99m, fluorine, or selenium-75.
Claim 20
Dependent Claim
33 words
The process of claim 1 including, said introducing step including introducing a cancer cell seeking agent in a concentration sufficient to combine with and selectively direct said minute particles to the cancer cells.
Claim 21
Dependent Claim
14 words
The process of claim 19 including, said cancer cell seeking agent being a radioisotope.
Claim 22
Dependent Claim
15 words
The process of claim 20 including, said radioisotope being gallium-67, indium-113m, technetium-99m, fluorine or selenium-75.
Claim 23
Dependent Claim
17 words
The process of claim 19 including, said cancer cell seeking agent being a tumor specific cancer antibody.
Claim 24
Dependent Claim
24 words
The process of claim 1 including, said minute particles including a chemotherapeutic agent specific for treating cancer and a coating around said chemotherapeutic agent.
Claim 25
Dependent Claim
18 words
The process of claim 23 including, said chemotherapeutic agent being 5-flurouracil, nitrogen mustard, actinomycin-D, methotrexate, cytoxan, or vincristine.
Claim 26
Dependent Claim
17 words
The process of claim 23 including, removing said coating from said chemotherapeutic agent, after said absorbing step.
Claim 27
Dependent Claim
19 words
The process of claim 15 including, said removing step including subjecting said minute particles to an increased oxygen supply.
Claim 28
Dependent Claim
24 words
The process of claim 23 including, said increasing the oxygen level step including removing said coating from said chemotherapeutic agent, after said absorbing step.
Claim 29
Dependent Claim
108 words
A process for the treatment of cancer cells in living tissue of a patient comprising the following steps: introducing into the living tissue of the patient minute particles of a total size not greater than one micron, capable of metabolizing and of reacting with another chemical, and having a chemotherapeutic agent and an agent coating solubilizable after a period of time by the cytoplasm of the cancer cell, depositing said minute particles intracellularly into the cancer cells, after said introducing step, and at least said period of time after said depositing step, solubilizing said coating and absorbing said chemotherapeutic agent in the cancer cells resulting in their death.
Claim 30
Dependent Claim
108 words
A process for the treatment of cancer cells in living tissue of a patient comprising the following steps: introducing into the living tissue of the patient minute particles of a total size not greater than one micron, capable of metabolizing and of reacting with another chemical, and having a chemotherapeutic agent and an agent coating solubilizable after a period of time by the cytoplasm of the cancer cell, depositing said minute particles intracellularly into the cancer cells, after said introducing step, and at least said period of time after said depositing step, solubilizing said coating and absorbing said chemotherapeutic agent in the cancer cells resulting in their death.
Claim 31
Dependent Claim
28 words
The process of claim 28 including, said chemotherapeutic agent being nitrogen mustard, antinomycin D, methotrexate, 5-flurouracil, cytoxan, or vincristine, and said coating comprising an iron dextran complex material.
Claim 32
Dependent Claim
30 words
The process of claim 29 including, after said depositing step before said period of time has passed, subjecting said minute particles to an increased oxygen supply to remove said coating.
References Cited (Backward Citations)
US3663685A
Cited
US3663686A
Cited
US3663687A
Cited
US3991770A
Cited
US4106488A
Cited
US4303636A
Cited
US4136683A
Cited
US4357259A
Cited
US4359453A
Cited
US4202323A
Cited
US4337760A
Cited
US4363793A
Cited
US4323056A
Cited
US4335044A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-10 | 1989-08-12 | 1990-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-10 | 1993-08-12 | 1994-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-10 | 1997-08-12 | 1998-02-11 | $7700.00 | Window Closed / Lapsed |