Patent US4537943A successfully refreshed from Google Patents.
US4537943A
Expired / Lapsed
US
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Correction of defects in the eye and compositions therefor
Assignee: Johnson and Johnson Surgical Vision Inc
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Filing: 1983-07-21
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Granted: 1985-08-27
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Expires: 2003-07-21
Abstract
Abstract A composition for forming in vivo a lens in an eye comprises silicone polymer and is curable at body temperature to form an optically clear lens which remains so in the presence of physiological fluids. The composition is generally a curable viscous liquid comprising (a) a crosslinkable siloxane polymer, (b) a crosslinker, and (c) a crosslinking catalyst for injecting into the lens capsule of the eye from which the natural lens has been removed.
Inventors
- 👤 Thomas D. Talcott
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:40
CPC Classifications
C; C08; C08G; C08G77/00; C08G77/04; A; A61; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/16; A61F2/1613; A61L; A61L27/00; A61L27/14; A61L27/18; C08G77/06; C08L; C08L83/00; C08L83/04; A61F2210/00; A61F2210/0085; C08G77/12; C08G77/14; C08G77/18; C08G77/20; C08G77/70; C08G77/80
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
448 words
A composition for forming in vivo a lens in the eye of a human being or other animal, said composition being substantially curable at body temperature to form a lens which is optically clear and remains so in the presence of physiological fluids, said composition being free of filler material and comprising: (a) a crosslinkable organosiloxane polymer containing crosslinkable hydrogen or alkenyl groups and having the average formula: ##STR14## wherein: M is a monofunctional, silicon-containing, chain capping residue; D is a difunctional, siloxane monomer unit, T is a trifunctional, siloxane monomer unit; and Q is a tetrafunctional siloxane monomer unit; and m and n are average numbers whose total is from about 2 to about 1000, n being a positive number greater than zero, m being zero or a positive number greater than zero; the average degree of polymerization of said polymer being from about 100 to about 20,000, the value of said degree of polymerization and m and n determining the average value of x; (b) an organosiloxane crosslinker polymer containing alkenyl groups when polymer (a) contains said crosslinkable hydrogen groups or hydrogen groups when said polymer (a) contains said crosslinkable alkenyl groups, polymer (b) having at least one of the following general formulae (i), (ii) and (iii): ##STR15## wherein the R substituents are substituted or unsubstituted and are the same or different and are selected from the group consisting of alkyl, aryl, alkaryl and aralkyl; R 1 is hydrogen or alkenyl; and q is an average number from about 1 to 250 times the value of q', q' being an average number of from about 3 to 20; the material of Formula VIII having an average degree of polymerization of from about 50 to 5,000, the average value of q being determined by the difference between the degree of polymerization and the average value of q'; ##STR16## wherein M is a monofunctional, silicon-containing, chain-capping residue; D is a difunctional siloxane monomer unit; T is a trifunctional siloxane monomer unit; and Q is a tetrafunctional siloxane monomer unit; and wherein n and x are average positive numbers, m is 0 or an average positive number, the total of n+m being from about 2 to 100 and, when m=0, n alone has these values, the degree of polymerization (DP) being from 50 to 5,000; and ##STR17## wherein R and R 1 are as defined above, n is an average number substantially equal to the average degree of polymerization of the material which is from about 50 to 5,000; and (c) a platinum complex catalyst capable of promoting a crosslinking reaction between said hydrogen or alkenyl groups in polymer (a) and said alkenyl or hydrogen groups in polymer (b).
Claim 2
Dependent Claim
448 words
A composition for forming in vivo a lens in the eye of a human being or other animal, said composition being substantially curable at body temperature to form a lens which is optically clear and remains so in the presence of physiological fluids, said composition being free of filler material and comprising: (a) a crosslinkable organosiloxane polymer containing crosslinkable hydrogen or alkenyl groups and having the average formula: ##STR14## wherein: M is a monofunctional, silicon-containing, chain capping residue; D is a difunctional, siloxane monomer unit, T is a trifunctional, siloxane monomer unit; and Q is a tetrafunctional siloxane monomer unit; and m and n are average numbers whose total is from about 2 to about 1000, n being a positive number greater than zero, m being zero or a positive number greater than zero; the average degree of polymerization of said polymer being from about 100 to about 20,000, the value of said degree of polymerization and m and n determining the average value of x; (b) an organosiloxane crosslinker polymer containing alkenyl groups when polymer (a) contains said crosslinkable hydrogen groups or hydrogen groups when said polymer (a) contains said crosslinkable alkenyl groups, polymer (b) having at least one of the following general formulae (i), (ii) and (iii): ##STR15## wherein the R substituents are substituted or unsubstituted and are the same or different and are selected from the group consisting of alkyl, aryl, alkaryl and aralkyl; R 1 is hydrogen or alkenyl; and q is an average number from about 1 to 250 times the value of q', q' being an average number of from about 3 to 20; the material of Formula VIII having an average degree of polymerization of from about 50 to 5,000, the average value of q being determined by the difference between the degree of polymerization and the average value of q'; ##STR16## wherein M is a monofunctional, silicon-containing, chain-capping residue; D is a difunctional siloxane monomer unit; T is a trifunctional siloxane monomer unit; and Q is a tetrafunctional siloxane monomer unit; and wherein n and x are average positive numbers, m is 0 or an average positive number, the total of n+m being from about 2 to 100 and, when m=0, n alone has these values, the degree of polymerization (DP) being from 50 to 5,000; and ##STR17## wherein R and R 1 are as defined above, n is an average number substantially equal to the average degree of polymerization of the material which is from about 50 to 5,000; and (c) a platinum complex catalyst capable of promoting a crosslinking reaction between said hydrogen or alkenyl groups in polymer (a) and said alkenyl or hydrogen groups in polymer (b).
Claim 3
Dependent Claim
28 words
A composition as claimed in claim 1, wherein, both before and after cure, less than about 40% to 50% by weight of said composition is extractable by solvent.
Claim 4
Dependent Claim
21 words
A composition as claimed in claim 2, wherein less than about 30% by weight of said composition is extractable by solvent.
Claim 5
Dependent Claim
18 words
A composition as claimed in claim 1, curable to a lens having a refractive index of about 1.4.
Claim 6
Dependent Claim
22 words
A composition as claimed in claim 1, divided into at least two vessels so as to separate component (b) from component (c).
Claim 7
Dependent Claim
33 words
A composition as claimed in claim 5, wherein one vessel contains component (c) and at least some of component (a) and another vessel contains component (b) and at least some of component (a).
Claim 8
Dependent Claim
65 words
A composition as claimed in claim 1, wherein said monofunctional units M are derived from polymerization of a polyorganosiloxane of the formula ##STR18## where the R radicals do not take part in the cross-linking reaction and are substituted or unsubstituted and are the same or different radicals selected from: alkyl, aryl, alkaryl and aralkyl; and wherein m is an average number up to about 30.
Claim 9
Dependent Claim
15 words
A composition as claimed in claim 7, wherein said R radicals are each methyl radicals.
Claim 10
Dependent Claim
134 words
A composition as claimed in claim 1, wherein said difunctional units D are derived from polymerization of a mixture of siloxanes of formula (IV) and (V) below: ##STR19## wherein the R radicals do not take part in the cross-linking reaction and are substituted or unsubstituted and are the same or different radicals and are selected from the group consisting of alkyl, aryl, alkaryl and aralkyl, said siloxane of formula (IV) being linear or cyclic, but when linear ##STR20## wherein R is as defined above and E is chloro, methoxy, ethoxy, acetoxy or hydroxy; and p is from 1 to 200; and when cyclic, A and B are chemical bonds joined together; and p is from 3 to 8; ##STR21## wherein, A,B,R and p are as defined above, and R 1 is H or alkenyl.
Claim 11
Dependent Claim
95 words
A composition as claimed in claim 1, wherein said trifunctional units T are derived from polymerization of at least one silicon compound of the formula: ##STR22## wherein R 2 is R or R 1 and R does not take part in the cross-linking reaction and is substituted or unsubstituted and selected from the group consisting of alkyl, aryl, alkaryl, and aralkyl, and R 1 is H or alkenyl; and W,Y and Z are the same of different substituents which in the formation of said crosslinkable polymer are converted to volatile or otherwise easily removable by-products.
Claim 12
Dependent Claim
24 words
A composition as claimed in claim 10, wherein W, Y and z are selected from C 1 -C 6 alkoxy, acetoxy, chloro and hydroxy.
Claim 13
Dependent Claim
55 words
A composition as claimed in claim 1, wherein said tetrafunctional residues Q are derived from polymerization of at least one silicon compound of the formula: ##STR23## wherein W, X, Y and Z are the same or different substituents which in the formation of said crosslinkable polymer are converted to volatile or otherwise easily removable by-products.
Claim 14
Dependent Claim
25 words
A composition as claimed in claim 12, wherein W, X, Y and Z are selected from, C 1 -C 6 alkoxy, acetoxy, chloro and hydroxy.
Claim 15
Dependent Claim
16 words
A composition as claimed in claim 1, wherein said catalyst component (c) comprises a platinum compound.
Claim 16
Dependent Claim
14 words
A composition as claimed in claim 14, wherein said platinum compound comprises chloroplatinic acid.
Claim 17
Dependent Claim
20 words
A composition as claimed in claim 1, wherein components (a) and (b) are substantially free of polar or ionic groups.
Claim 18
Dependent Claim
24 words
A composition as claimed in claim 16 wherein said components (a) and (b) are prepared by polymerization in the presence of an acid catalyst.
Claim 19
Dependent Claim
18 words
A composition as claimed in claim 1, wherein polymer (a) is prepared from octamethylcyclotetrasiloxane; polydimethylsiloxane; tetravinyltetramethylcyclotetrasiloxane; and methyltriacetoxy-silane.
Claim 20
Dependent Claim
18 words
A composition as claimed in claim 1, wherein polymer (a) is prepared from octamethylcyclotetrasiloxane; polydimethylsiloxane; 1,1,2,2,-tetramethyl-1,2-divinyldisiloxane; and methyltriacetoxy-silane.
Claim 21
Dependent Claim
18 words
A composition as claimed in claim 1, wherein polymer (a) is prepared from dimethyldichlorosilane; octamethylcyclotetrasiloxane; trimethylchlorosilane; and vinyltri-chlorosilane.
Claim 22
Dependent Claim
19 words
A composition as claimed in claim 1, wherein polymer (a) is prepared from dimethyldichlorosilane; octamethylcyclotetrasiloxane; trimethylchlorosilane; vinyltrichlorosilane; and methyltrichlorosilane.
Claim 23
Dependent Claim
18 words
A composition as claimed in claim 1, wherein polymer (a) is prepared from octamethylcyclotetrasiloxane; polydimethylsiloxane; vinyldiacetoxysilane; and methyltriacetoxysilane.
Claim 24
Dependent Claim
18 words
A composition as claimed in claim 1, wherein polymer (a) is prepared from octamethylcyclotetrasiloxane; polydimethylsiloxane; vinyltriacetoxysilane; and tetracetoxysilane.
Claim 25
Dependent Claim
23 words
A composition as claimed in claims 1, 18, 19, 20, 21, 22 or 23, wherein polymer (b) is prepared from polymethylhydrogensiloxane and octamethylcyclotetrasiloxane.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-26 | 1989-02-25 | 1989-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-26 | 1993-02-25 | 1993-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-26 | 1997-02-25 | 1997-08-27 | $7700.00 | Window Closed / Lapsed |