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US4532134A
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Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
Assignee: TRITON CHITO
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Filing: 1982-11-08
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Granted: 1985-07-30
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Expires: 2002-11-08
Abstract
Abstract The method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration is described wherein a chitosan solution, or water-soluble chitosan in various solid forms is placed in contact with the tissue wound. The chitosan forms a coagulum which prevents bleeding and negates the formation of a blood clot thereby preventing the formation of fibrin strands. The prevention of the formation of fibrin strands prevents the proliferation of fibroblasts and the synthesis of collagen thereby allowing the promotion of normal tissue regeneration. The process described hereinabove results in wound healing with minimal scar formation. The use of chitosan in grafts is contemplated as well as the use of polyglucosamine in wound healing.
Inventors
- 👤 William G. Malette
- 👤 Herbert J. Quigley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/28; A61P; A61P43/00; A61P7/00; A61P7/04; A61L2430/00; A61L2430/36
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
84 words
The method of inhibiting fibroplasia and promoting tissue regeneration in vascular grafts which comprises placing, an effective amount of chitosan in contact with the graft, said chitosan being between 42 to 100 percent deacetylated; said chitosan having a molecular weight range of 10,000 to 2,055,00; said chitosan being soluble in distilled water and an acid selected from the group of hydrochloric, sulphuric, phosphoric and organic acid having an acid concentration of 0.02 to 1.0N; said chitosan solution having a pH of 1 to 8.
Claim 2
Independent Claim
84 words
The method of inhibiting fibroplasia and promoting tissue regeneration in vascular grafts which comprises placing, an effective amount of chitosan in contact with the graft, said chitosan being between 42 to 100 percent deacetylated; said chitosan having a molecular weight range of 10,000 to 2,055,00; said chitosan being soluble in distilled water and an acid selected from the group of hydrochloric, sulphuric, phosphoric and organic acid having an acid concentration of 0.02 to 1.0N; said chitosan solution having a pH of 1 to 8.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the chitosan is incorporated in the graft material.
Claim 4
Independent Claim
84 words
The method of inhibiting fibroplasia and promoting tissue regeneration in a wound which comprises placing in contact with said wound an effective amount of chitosan, said chitosan being between 42 to 100 percent deacetylated; said chitosan having a molecular weight range of 10,000 to 2,055,00; said chitosan being soluble in distilled water and an acid selected from the group of hydrochloric, sulphuric, phosphoric and organic acid having an acid concentration of 0.02 to 1.0N; said chitosan solution having a pH of 1 to 8.
Claim 5
Independent Claim
84 words
The method of inhibiting fibroplasia and promoting tissue regeneration in a wound which comprises placing in contact with said wound an effective amount of chitosan, said chitosan being between 42 to 100 percent deacetylated; said chitosan having a molecular weight range of 10,000 to 2,055,00; said chitosan being soluble in distilled water and an acid selected from the group of hydrochloric, sulphuric, phosphoric and organic acid having an acid concentration of 0.02 to 1.0N; said chitosan solution having a pH of 1 to 8.
Claim 6
Dependent Claim
13 words
The method of claim 3 wherein said chitosan is 78 to 92% deacetylated.
Claim 7
Dependent Claim
24 words
The method of claim 3 wherein the chitosan is in solution with distilled water and acetic acid and has a pH of approximately 4.
Claim 8
Dependent Claim
12 words
The method of claim 3 wherein said chitosan is in solid form.
Claim 9
Dependent Claim
19 words
The method of claim 6 wherein said chitosan is a salt prepared by dehydrating an acid solution of chitosan.
Claim 10
Dependent Claim
11 words
The method of claim 7 wherein said chitosan comprises a powder.
Claim 11
Dependent Claim
11 words
The method of claim 7 wherein said chitosan is a film.
Claim 12
Dependent Claim
11 words
The method of claim 7 wherein said chitosan is a sheet.
Claim 13
Dependent Claim
12 words
The method of claim 7 wherein said chitosan is in fiber form.
Claim 14
Dependent Claim
13 words
The method of claim 11 wherein said chitosan fibers are formed into mats.
Claim 15
Dependent Claim
13 words
The method of claim 11 wherein said chitosan fibers are formed into plugs.
Claim 16
Dependent Claim
14 words
The method of claim 3 wherein the blood of the wounded subject is anticoagulated.
Claim 17
Dependent Claim
11 words
The method of claim 3 wherein the wound is locally anticoagulated.
Claim 18
Independent Claim
28 words
The method of achieving hemostasis, inhibiting fibroplasia and for promoting tissue regeneration in a wound which comprises placing an effective amount of polyglucosamine in contact with the wound.
Claim 19
Independent Claim
28 words
The method of achieving hemostasis, inhibiting fibroplasia and for promoting tissue regeneration in a wound which comprises placing an effective amount of polyglucosamine in contact with the wound.
References Cited (Backward Citations)
US3632754A
Cited
US3911116A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-29 | 1989-01-28 | 1989-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-29 | 1993-01-28 | 1993-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-29 | 1997-01-28 | 1997-07-30 | $7700.00 | Window Closed / Lapsed |