Patent US4512762A successfully refreshed from Google Patents.
US4512762A
Expired / Lapsed
US
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Method of treatment of atherosclerosis and a balloon catheter for same
Assignee: Beth Israel Deaconess Medical Center
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Filing: 1982-11-23
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Granted: 1985-04-23
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Expires: 2002-11-23
Abstract
Abstract A method for the treatment of atherosclerosis in a mammal by destruction of atheromatous plaque is disclosed. The disclosed method includes injecting a hematoporphyrin into the mammal for selective uptake into the atheromatous plaque, and delivering light to the diseased vessel so that the light activates the hematoporphyrin for lysis of the plaque. The preferred method utilizes a balloon catheter equipped with flexible optical fibers for transmission of light from an external source for illumination of the interior of the inflated balloon. By inflation of the balloon, the opaque blood between the balloon and the atheromatous plaque is displaced to facilitate activation of the hematoporphyrin. The balloon may be illuminated and inflated and deflated in a cycle responsive to the patient's pulse so as to minimize interference with blood flow.
Inventors
- 👤 James R. Spears
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:48
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/104; A61B; A61B17/00; A61B17/22; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; A61B18/245; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61B2017/00681; A61B2017/00694; A61B2017/22038; A61B2017/22051; A61B2017/22057; A61B2017/22059; A61B2017/22082; A61B2017/22085; A61B2017/22087; A61B2018/2255; A61B2018/2261; A61B90/00; A61B90/30; A61B2090/306; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
82 words
A method for the treatment of atherosclerosis in a mammal by destruction of atheromatous plaque in a diseased blood vessel, said process comprising: injecting a hematoporphyrin into the mammal to be treated for selective uptake into the atheromatous plaque; inserting a light-emitting catheter into the diseased vessel so that the light-emitting portion of the catheter is adjacent the atheromatous plaque to be lysed; and exposing the hematoporphyrin within said atheromatous plaque to light transmitted through the catheter for lysis of the plaque.
Claim 2
Independent Claim
82 words
A method for the treatment of atherosclerosis in a mammal by destruction of atheromatous plaque in a diseased blood vessel, said process comprising: injecting a hematoporphyrin into the mammal to be treated for selective uptake into the atheromatous plaque; inserting a light-emitting catheter into the diseased vessel so that the light-emitting portion of the catheter is adjacent the atheromatous plaque to be lysed; and exposing the hematoporphyrin within said atheromatous plaque to light transmitted through the catheter for lysis of the plaque.
Claim 3
Dependent Claim
40 words
The method of claim 1 wherein the catheter is a balloon catheter and wherein said method further comprises illuminating the balloon and inflating the balloon to displace the blood between the illuminated balloon and the atheromatous plaque to be lysed.
Claim 4
Dependent Claim
10 words
The method of claim 1 wherein said injection is intravenous.
Claim 5
Dependent Claim
15 words
The method of claim 1 wherein said source of said illumination is a dye laser.
Claim 6
Dependent Claim
16 words
The method of claim 1 wherein said hematoporphyrin is an acetic acid-sulfuric acid derivative of hematoporphyrin.
Claim 7
Dependent Claim
11 words
The method of claim 2 wherein said balloon inflation is intermittent.
Claim 8
Dependent Claim
22 words
The method of claim 6 wherein the balloon is intermittently inflated responsive to ECG-gating so as to minimize interference with blood flow.
Claim 9
Dependent Claim
13 words
The method of claim 7 wherein the balloon is illuminated only when inflated.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-22 | 1988-10-22 | 1989-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-22 | 1992-10-22 | 1993-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-22 | 1996-10-22 | 1997-04-23 | $7700.00 | Window Closed / Lapsed |