US4511713A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
Assignee: Johns Hopkins University
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Filing: 1982-03-29
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Granted: 1985-04-16
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Expires: 2002-03-29
Abstract
Abstract A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for the nucleic acid and binding the nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.
Inventors
- 👤 Paul S. Miller
- 👤 Paul O. P. Ts'o
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:33
CPC Classifications
C; C07; C07H; C07H21/00; Y; Y10; Y10S; Y10S530/00; Y10S530/808; Y10S530/809
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
62 words
A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for said nucleic acid and binding the said nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.
Claim 2
Dependent Claim
62 words
A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for said nucleic acid and binding the said nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.
Claim 3
Dependent Claim
13 words
The process of claim 1 wherein the phosphonate analogue is an oligonucleoside methylphosphonate.
Claim 4
Dependent Claim
14 words
The process of claim 2 wherein the phosphonate analogue is introduced into the cells.
Claim 5
Dependent Claim
30 words
The process of claim 3 wherein the analogue is used to control protein synthesis caused by the foreign nucleic acid, or the replication and expression of the foreign nucleic acids.
Claim 6
Dependent Claim
20 words
The process of claim 1 wherein the analogue is complementary to a 3-20 base sequence of the foreign nucleic acid.
References Cited (Backward Citations)
US3560478A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-15 | 1988-10-15 | 1989-04-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-15 | 1992-10-15 | 1993-04-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-15 | 1996-10-15 | 1997-04-16 | $7700.00 | Window Closed / Lapsed |