Analogues of nucleoside phosphates

Abstract

Abstract BASE-SUGAR-R-P(=O)(-OH)-O-P(=O)(-OH)-R-P(=O)(-R'')2 PHOSPHONATE DERIVATIVES OF BASE-SUGAR PHOSPHATES HAVING THE FORMULAE: MONOPHOSPHONATES: MONOPHOSPHONATES: BASE-SUGAR-P(=O)(-R'')2 BASE-SUGAR-O-P(=O)(-R'')2 DIPHOSPHONATES: BASE-SUGAR-P(=O)(-OH)-O-P(=O)(-R'')2 BASE-SUGAR-R-P(=O)(-OH)-O-P(=O)(-R'')2 BASE-SUGAR-P(=O)(-OH)-R-P(=O)(-R'')2 BASE-SUGAR-R-P(=O)(-OH)-R-P(=O)(-R'')2 BASE-SUGAR-O-P(=O)(-OH)-R-P(=O)(-R'')2 TRIPHOSPHONATES: BASE-SUGAR-P(=O)(-OH)-O-P(=O)(-OH)-R-P(=O)(-R'')2 BASE-SUGAR-P(=O)(-OH)-O-P(=O)(-OH)-O-P(=O)(-R'')2 BASE-SUGAR-P(=O)(-OH)-R-P(=O)(-OH)-O-P(=O)(-R'')2 BASE-SUGAR-P(=O)(-OH)-R-P(=O)(-OH)-R-P(=O)(-R'')2 BASE-SUGAR-O-P(=O)(-OH)-O-P(=O)(-OH)-R-P(=O)(-R'')2 BASE-SUGAR-O-P(=O)(-OH)-R-P(=O)(-OH)-O-P(=O)(-R'')2 BASE-SUGAR-O-P(=O)(-OH)-R-P(=O)(-OH)-R-P(=O)(-R'')2 BASE-SUGAR-R-P(=O)(-OH)-O-P(=O)(-OH)-O-P(=O)(-R'')2 IN WHICH AT LEAST ONE OF THE R'' GROUPS IS SELECTED FROM THE GROUP CONSISTING OF R" AND OR" IN WHICH R" IS A MONOVALENT ORGANIC GROUP SELECTED FROM THE GROUP CONSISTING OF A LOWER ALIPHATIC GROUP AND HALOGEN DERIVATIVES THEREOF, A FATTY ACID GROUP AND HALOGENATED DERIVATIVES THEREOF, AN ARYL GROUP AND HALOGENATED DERIVATIVES THEREOF, AN ALKARYL GROUP AND HALOGENATED DERIVATIVES THEREOF, A HETEROCYCLIC GROUP AND A BASE SUGAR GROUP AND IN WHICH THE BASE IS SELECTED FROM THE GROUP CONSISTING OF A PURINE BASE AND A PYRIMIDINE BASE. BASE-SUGAR-R-P(=O)(-OH)-R-P(=O)(-OH)-O-P(=O)(-R'')2 BASE-SUGAR-R-P(=O)(-OH)-R-P(=O)(-OH)-R-P(=O)(-R'')2

Inventors

• 👤 Terrell C Myers

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