Patent US4510125A successfully refreshed from Google Patents.
US4510125A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for making lyophilized radiographic imaging kit
Assignee: Mallinckrodt Inc
•
Filing: 1982-12-08
•
Granted: 1985-04-09
•
Expires: 2002-12-08
Abstract
Abstract A process for making a lyophilized composition useful for skeletal imaging whereby an aqueous solution containing an ascorbate, gentisate, or reductate stabilizer is contacted with tin metal or an alloy containing tin and, thereafter, lyophilized. Preferably, such compositions also comprise a tissue-specific carrier and a stannous compound. It is particularly preferred to incorporate stannous oxide as a coating on the tin metal.
Inventors
- 👤 Terry W. Grogg
- 👤 Joseph E. Bugaj
- 👤 Paul E. Bates
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:55
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1241; A61K2123/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
59 words
A process, for producing a dry-powder composition, useful for skeletal imaging, comprising the steps of: (a) preparing a solution which comprises a stabilizer selected from the group consisting of gentisate, ascorbate, and reductate compounds, and mixtures thereof; (b) contacting said solution with a metal selected from the group consisting of tin and tin-containing alloys; and (c) lyophilizing said solution.
Claim 2
Dependent Claim
59 words
A process, for producing a dry-powder composition, useful for skeletal imaging, comprising the steps of: (a) preparing a solution which comprises a stabilizer selected from the group consisting of gentisate, ascorbate, and reductate compounds, and mixtures thereof; (b) contacting said solution with a metal selected from the group consisting of tin and tin-containing alloys; and (c) lyophilizing said solution.
Claim 3
Dependent Claim
14 words
A process, as in claim 1, wherein said solution further comprises a tissue-specific carrier.
Claim 4
Dependent Claim
13 words
A process, as in claim 2, wherein said tissue-specific carrier is an organodiphosphonate.
Claim 5
Dependent Claim
43 words
A process, as in claim 3, wherein said organodiphosphonate is selected from the group consisting of methane diphosphonic acid, hydroxymethane diphosphonic acid, ethane-1-hydroxy-1,1-diphosphonic acid, methaneamino diphosphonic acid, methane-N-methylamino diphosphonic acid, methane-N,N-dimethylaminodiphosphonic acid, propane-1-hydroxy-3-amino-1,1-diphosphonic acid, ethane-1-hydroxy-2-amino-1,1-diphosphonic acid, and the pharmaceutically-acceptable salts and mixtures thereof.
Claim 6
Dependent Claim
22 words
A process, as in claim 1, wherein said stabilizer is selected from the group consisting of gentisic acid and pharmaceutically-acceptable salts thereof.
Claim 7
Dependent Claim
28 words
A process, as in claim 1, wherein said stabilizer is selected from the group consisting of ascorbic acid, erythorbic acid, and the pharmaceutically-acceptable salts, esters and mixtures thereof.
Claim 8
Dependent Claim
14 words
A process, as in claim 1, wherein said solution further comprises a stannous compound.
Claim 9
Dependent Claim
30 words
A process, as in claim 7, wherein said stannous compound is selected from the group consisting of stannous chloride, stannous fluoride, stannous tartrate, stannous citrate, stannous oxide and mixtures thereof.
Claim 10
Dependent Claim
14 words
A process, as in claim 7, wherein said stannous compound is an organo phosphonate.
Claim 11
Dependent Claim
14 words
A process, as in claim 1, wherein said metal is coated with stannous oxide.
Claim 12
Dependent Claim
33 words
A process, as in claim 1, wherein said solution is adjusted so as to have a pH in the range from about 1.0 to about 6.0 while in said contact with said metal.
Claim 13
Dependent Claim
17 words
A dry-powder composition, useful for skeletal imaging comprising the product of the process recited in claim 1.
Claim 14
Dependent Claim
17 words
A dry-powder composition, useful for skeletal imaging comprising the product of the process recited in claim 2.
References Cited (Backward Citations)
US3749556A
Cited
US3902849A
Cited
DE2618337A1
Cited
US4311689A
Cited
US4233284A
Cited
US4229427A
Cited
US4232000A
Cited
US4247534A
Cited
US4314986A
Cited
EP0046067A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-08 | 1988-10-08 | 1989-04-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-08 | 1992-10-08 | 1993-04-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-08 | 1996-10-08 | 1997-04-09 | $7700.00 | Window Closed / Lapsed |