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US4474851A
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Elastomeric composite material comprising a polypeptide
Assignee: UAB RESEARCH FOUNDATION NON-PROFIT CORP
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Filing: 1981-10-02
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Granted: 1984-10-02
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Expires: 2001-10-02
Abstract
Abstract An elastomeric composite material formed from an artificial core fiber and an elastomeric polypeptide chemically bonded to the surface of the core fiber, where the polypeptide comprises tetrapeptide or pentapeptide repeating units or mixtures thereof, the repeating units comprise hydrophobic amino acid or glycine residues, and the amino acid residues of a given repeating unit exist in a conformation having a β-turn. Also disclosed are elastomeric fabrics formed from the elastomeric composite and the use of such fabrics in vascular prosthesis, as well as a method of forming such elastomeric composite materials.
Inventors
- 👤 Dan W. Urry
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:59
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2929; Y10T428/2931; Y10T428/2933; Y10T428/2964; Y10T428/2967; Y10T428/2969
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
82 words
An elastomeric composite material comprising: an artificial core fiber, and an elastomeric polypeptide chemically bonded to the surface of said core fiber, wherein said polypeptide comprises tetrapeptide or pentapeptide repeating units or mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine resisues and wherein said repeating units exist in a conformation having a β-turn, and the molecules of said elastomeric polypeptide are cross-linked by irradiating said polypeptide with ionizing radiation.
Claim 2
Dependent Claim
82 words
An elastomeric composite material comprising: an artificial core fiber, and an elastomeric polypeptide chemically bonded to the surface of said core fiber, wherein said polypeptide comprises tetrapeptide or pentapeptide repeating units or mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine resisues and wherein said repeating units exist in a conformation having a β-turn, and the molecules of said elastomeric polypeptide are cross-linked by irradiating said polypeptide with ionizing radiation.
Claim 3
Dependent Claim
23 words
The elastomeric composite material of claim 1, wherein said hydrophobic amino acid residues are selected from the group consisting of hydrophobic α-amino acids.
Claim 4
Dependent Claim
29 words
The elastomeric composite material of claim 2 wherein said hydrophobic amino acid residues are selected from the group consisting of alanine, valine, leucine, isoleucine, proline, phenylalanine, tryptophan, and methionine.
Claim 5
Dependent Claim
25 words
The elastomeric composite material of claim 3, wherein the first amino acid residue of said repeating units is a residue of valine, leucine, or isoleucine.
Claim 6
Dependent Claim
22 words
The elastomeric composite material of claim 3 wherein the second amino acid residue of said repeating units is a residue of proline.
Claim 7
Dependent Claim
22 words
The elastomeric composite material of claim 3 wherein the third amino acid residue of said repeating units is a residue of glycine.
Claim 8
Dependent Claim
24 words
The elastomeric composite material of claim 3 wherein the fourth amino acid residue of said repeating units is a residue of tryptophan or glycine.
Claim 9
Dependent Claim
12 words
The elastomeric composite material of claim 1 wherein said tetrapeptide is Val-Pro-Gly-Gly.
Claim 10
Dependent Claim
12 words
The elastomeric composite material of claim 1 wherein said pentapeptide is Val-Pro-Gly-Val-Gly.
Claim 11
Dependent Claim
21 words
The elastomeric material of claim 1, wherein said core fiber has a tensile strength of at least 10 kg/mm 2 .
Claim 12
Dependent Claim
19 words
The elastomeric composite material of claim 1, wherein the molecular weight of said polypeptide is at least 10,000 daltons.
Claim 13
Dependent Claim
23 words
The elastomeric composite fiber of claim 1, wherein the weight ratio of said core fiber to said polypeptide is from 10:1 to 1:10.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-02 | 1988-04-02 | 1988-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-02 | 1992-04-02 | 1992-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-02 | 1996-04-02 | 1996-10-02 | $7700.00 | Window Closed / Lapsed |