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US4462941A
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Dynorphin amide analogs
Assignee: DYNORPHIN PARTNERSHIP A PARTNERSHIP OF CALIFORNIA
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Filing: 1982-06-10
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Granted: 1984-07-31
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Expires: 2002-06-10
Abstract
Abstract Dynorphin(1-13) has been previously reported to antagonize the analgesia induced by narcotics in naive hosts. Novel compounds are provided which differ from dynorphin(1-13) by neither potentiating nor antagonizing narcotics, such as morphine, in naive animals. In tolerant hosts the new compounds potentiate narcotic or peptide induced analgesia, and in addition are less susceptible to degradation than dynorphin(1-13). Particularly preferred of the new compounds are polypeptides having ten amino acids with nitrogen containing moieties at both termini.
Inventors
- 👤 Nancy M. Lee
- 👤 Horace H. Loh
- 👤 Jaw-Kang Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:01
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/665; A; A61; A61P; A61P25/00; A61P25/04; A61K; A61K38/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
41 words
A dynorphin analog having the sequence TYR-GLY-GLY-PHE-LEU-ARG-ARG-AA 8 -AA 9 -AA 10 wherein AA 8 is isoleucine, leucine or lysine, AA 9 is arginine or proline, AA 10 is proline and a carbonyl carbon at the AA 10 terminus is amidated.
Claim 2
Dependent Claim
41 words
A dynorphin analog having the sequence TYR-GLY-GLY-PHE-LEU-ARG-ARG-AA 8 -AA 9 -AA 10 wherein AA 8 is isoleucine, leucine or lysine, AA 9 is arginine or proline, AA 10 is proline and a carbonyl carbon at the AA 10 terminus is amidated.
Claim 3
Dependent Claim
22 words
A polypeptide having the sequence TYR-GLY-GLY-PHE-LEU-ARG-ARG-AA 8 -ARG-PRO wherein the proline thereof is amidated and AA 8 is tyrosine, isoleucine or lysine.
Claim 4
Dependent Claim
22 words
A polypeptide having the sequence TYR-GLY-GLY-PHE-LEU-ARG-ARG-AA 8 -ARG-PRO wherein the proline thereof is amidated and AA 8 is tyrosine, isoleucine or lysine.
Claim 5
Dependent Claim
11 words
The polypeptide as in claim 2 wherein AA 8 is isoleucine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-31 | 1988-01-30 | 1988-07-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-31 | 1992-01-30 | 1992-07-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-31 | 1996-01-30 | 1996-07-31 | $7700.00 | Window Closed / Lapsed |