US4460563A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing microcapsules in a liquid vehicle
Assignee: Adare Pharmaceuticals SRL
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Filing: 1981-04-02
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Granted: 1984-07-17
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Expires: 2001-04-02
Abstract
Abstract The invention relates to a process for preparing microcapsules in a liquid vehicle, allowing to microencapsulate both water soluble and water insoluble substances, using either ionic or non-ionic systems, in which the membrane enclosing the core of the microcapsules is formed by a polymer selected from the group of the phthalates, and more particularly by hydroxypropylmethylcellulose phthalate.
Inventors
- 👤 Massimo Calanchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5042; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
149 words
A process for preparing microcapsules in a liquid vehicle, comprising the following steps: (1) dissolution of a membrane-forming cellulosic polymer in a solvent which is the microencapsulation vehicle; (2) addition of cores of a substance to be microencapsulated to said solution; (3) formation of a coacervate by adding a substance adapted to cause phase separation; (4) deposition of the coacervate, forming a continuous coating of polymer around the cores of the substance; and (5) solidification of the polymer; the improvement comprising the fact that the membrane-forming cellulosic polymer is a cellulose phthalate having the following chemical structure: ##STR2## wherein R is hydrogen or a methyl, hydroxypropyl, carboxybenzoyl, 2-(2-carboxybenzoyl)propyl, or acetyl group, at least one R being always carboxybenzoyl, that the polymer is dissolved in aqueous or buffer solution, and that the phase separator is a substance causing phase separation of the cellulose phthalate from aqueous solution at a pH≧5.
Claim 2
Dependent Claim
149 words
A process for preparing microcapsules in a liquid vehicle, comprising the following steps: (1) dissolution of a membrane-forming cellulosic polymer in a solvent which is the microencapsulation vehicle; (2) addition of cores of a substance to be microencapsulated to said solution; (3) formation of a coacervate by adding a substance adapted to cause phase separation; (4) deposition of the coacervate, forming a continuous coating of polymer around the cores of the substance; and (5) solidification of the polymer; the improvement comprising the fact that the membrane-forming cellulosic polymer is a cellulose phthalate having the following chemical structure: ##STR2## wherein R is hydrogen or a methyl, hydroxypropyl, carboxybenzoyl, 2-(2-carboxybenzoyl)propyl, or acetyl group, at least one R being always carboxybenzoyl, that the polymer is dissolved in aqueous or buffer solution, and that the phase separator is a substance causing phase separation of the cellulose phthalate from aqueous solution at a pH≧5.
Claim 3
Dependent Claim
19 words
A process according to claim 1, wherein the polymer forming the membrane of the microcapsules is hydroxypropylmethylcellulose phthalate (HPMCP).
Claim 4
Dependent Claim
16 words
A process according to claims 1 or 2, wherein another polymer is present in the membrane.
Claim 5
Dependent Claim
16 words
A process according to claim 1 or 2, wherein a plasticizer is present in the membrane.
Claim 6
Dependent Claim
23 words
A process according to claim 1 or 2, wherein the microencapsulation vehicle is an aqueous solution or a buffer solution having a pH≧5.
Claim 7
Dependent Claim
24 words
A process according to claim 1 or 2, wherein the ratio between the substance to be microencapsulated and membrane is between 0.5:1 and 100:1.
Claim 8
Dependent Claim
17 words
A process according to claim 1 or 2, wherein the microencapsulation is fostered by adding a surfactant.
Claim 9
Dependent Claim
30 words
A process according to claim 1 or 2, wherein the membrane of the microcapsules is reacted with material adapted to harden the membrane at a pH value less than 5.
Claim 10
Dependent Claim
26 words
A process according to claim 1 or 2, wherein drying of microcapsules is fostered by adding a substance adapted to absorb water and dehydrate the membrane.
Claim 11
Dependent Claim
26 words
A process according to claim 1 or 2, wherein the membrane of the microcapsules is made impermeable by means of a post treatment with a wax.
Claim 12
Dependent Claim
15 words
A process of claim 9, wherein the added substance is a silicium dioxide or silicate.
Claim 13
Dependent Claim
11 words
A process of claim 8, wherein the material is an acid.
Claim 14
Dependent Claim
23 words
A pharmaceutical substance microencapsulated with a membrane-forming cellulose phthalate polymer by coacervation from an aqueous vehicle produced by the procedure of claim 1.
Claim 15
Dependent Claim
13 words
A process of claim 2, wherein gelatine is also present in the membrane.
Claim 16
Dependent Claim
18 words
A process of claim 12, wherein gelatine is also present in the membrane and wherein aldehyde is added.
Claim 17
Dependent Claim
25 words
A process according to claim 1 or 2, wherein the ratio between the substance to be microencapsulated and the membrane is between 1:1 and 20:1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-17 | 1988-01-16 | 1988-07-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-17 | 1992-01-16 | 1992-07-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-17 | 1996-01-16 | 1996-07-17 | $7700.00 | Window Closed / Lapsed |