GB2041942A
Expired / Lapsed
GB
⏱️ 0.0 years remaining
Tissue adhesive
Assignee: Oesterreichisches Institut fuer Haemoderivate
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Filing: 1980-02-05
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Granted: —
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Expires: 2000-02-05
Abstract
No abstract record available.
Inventors
No inventors recorded.
Bibliographic Details
Application Number
—
Jurisdiction
GB
Data Source
google_patents
Last Synchronized
2026-10-22 22:09
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61K38/00; A61K38/005; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
101 words
A tissue adhesive on the basis of human or animal proteins and containing fibrinogen and factor Xill, which tissue adhesive is characterized in that a) it contains at least 33% by weight of fibrinogen, b) the ratio of factor X111 to fibrinogen, expressed in units of factor X111 per gram of fibrinogen, amounts to at least 80, c) fibrinogen and albumin are contained in the 0 total protein at a ratio of 33 to 90:5 to 40, d) it contains plasminogen-activator-inhibitor or plasmin inhibitor in an amount of 250 to 25,000 KIU per g of fibrinogen, and e) it is Iyophilized.
Claim 2
Dependent Claim
101 words
A tissue adhesive on the basis of human or animal proteins and containing fibrinogen and factor Xill, which tissue adhesive is characterized in that a) it contains at least 33% by weight of fibrinogen, b) the ratio of factor X111 to fibrinogen, expressed in units of factor X111 per gram of fibrinogen, amounts to at least 80, c) fibrinogen and albumin are contained in the 0 total protein at a ratio of 33 to 90:5 to 40, d) it contains plasminogen-activator-inhibitor or plasmin inhibitor in an amount of 250 to 25,000 KIU per g of fibrinogen, and e) it is Iyophilized.
Claim 3
Dependent Claim
16 words
A tissue adhesive as set forth in claim 1, wherein the plasminogen-activator-inhibitor or plasmin-inhibitor is aprotinin.
Claim 4
Dependent Claim
12 words
A tissue adhesive as set forth in claim 1, further containing glycine.
Claim 5
Dependent Claim
12 words
A tissue adhesive as set forth in claim 1, further containing glucose.
Claim 6
Dependent Claim
12 words
A tissue adhesive as set forth in claim 1, further containing sucrose.
Claim 7
Dependent Claim
22 words
A tissue adhesive as set forth in claim 1, which contains 0.2 to 200 IU of heparin per g of fibrinogen. -
Claim 8
Dependent Claim
62 words
A tissue adhesive as set forth in claim 1 being capable, after dissolution of the Iyophilized 1 f 3 GB 2 041 942 A- 3 preparation, of complete cross-linking of the fibrin-T-chains after 3 to 5 minutes of incubation, 25 and of at least 35% cross-linking of the fibrin-achains after 2 hours of incubation, determined 5 according to the SDS-polyacrylamide-gel- electrophoresis method.
Claim 9
Dependent Claim
33 words
A tissue adhesive as set forth in claim 1, 30 wherein the ratio of fibrinogen to albumin to cold insoluble globulin in the total protein is 33 to 90:5 to 40:0.2 to 15.
Claim 10
Independent Claim
67 words
A method of producing a tissue adhesive as set forth in cilaim 1 from plasma cryoprecipitate, 35 which method comprises removing from the cryoprecipitate plasma- protein that is soluble in the cold, by treating the cryoprecipitate with a buffer solution containing sodium citrate, sodium chloride, glycine, glucose, 40 a plasminogen-activator-inhibitor or plasmininhibitor, and heparin, 20 dissolving the purified precipitate, adding human albumin, and lyophilizing the resulting solution.
Claim 11
Independent Claim
67 words
A method of producing a tissue adhesive as set forth in cilaim 1 from plasma cryoprecipitate, 35 which method comprises removing from the cryoprecipitate plasma- protein that is soluble in the cold, by treating the cryoprecipitate with a buffer solution containing sodium citrate, sodium chloride, glycine, glucose, 40 a plasminogen-activator-inhibitor or plasmininhibitor, and heparin, 20 dissolving the purified precipitate, adding human albumin, and lyophilizing the resulting solution.
Claim 12
Dependent Claim
18 words
A method as set forth in claim 9, wherein the cryoprecipitate is treated once with said buffer solution.
Claim 13
Dependent Claim
19 words
A method as set forth in claim 9, wherein the cryoprecipitate is treated several times with said buffer solution.
Claim 14
Dependent Claim
31 words
A method of using the tissue adhesive set forth in claim 1 for seamlessly connecting human or animal tissue or organ parts, for sealing wounds, stopping bleedings and stimulating wound healing.
Claim 15
Dependent Claim
25 words
A method as set forth in claim 12, wherein the tissue adhesive and a mixture of thrombin and calcium chloride are applied onto the tissue.
Claim 16
Dependent Claim
33 words
A method as set forth in claim 12, wherein, prior to applying the tissue adhesivQ onto the tissue to be connected, a mixture of thrombirn and calcium chloride is added to the adhesive.
Claim 17
Dependent Claim
13 words
A tissue adhesive substantially as hereinbefore described with reference to the accompanying example.
Claim 18
Dependent Claim
13 words
A tissue adhesive substantially as hereinbefore described with reference to the accompanying example.
Claim 19
Independent Claim
43 words
A method substantially as hereinbefore described with reference to the accompanying example. Printed for Her Majesty's Stationery Office by the Courier Press, Leamington Spa, 1980. Published by the Patent Office, 25 Southampton Buildings, London, WC2A 1 AY, from which copies may be obtained.
Claim 20
Independent Claim
43 words
A method substantially as hereinbefore described with reference to the accompanying example. Printed for Her Majesty's Stationery Office by the Courier Press, Leamington Spa, 1980. Published by the Patent Office, 25 Southampton Buildings, London, WC2A 1 AY, from which copies may be obtained.
References Cited (Backward Citations)
No citation records indexed.
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