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US4450841A
Expired / Lapsed
US
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Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
Assignee: Thomas Jefferson University
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Filing: 1982-09-30
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Granted: 1984-05-29
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Expires: 2002-09-30
Abstract
Abstract A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
Inventors
- 👤 Jewell L. Osterholm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:54
CPC Classifications
A; A61; A61M; A61M3/00; A61M3/02; A61B; A61B5/00; A61B5/145; A61B5/14507; A61B5/14542; A61B5/40; A61B5/4058; A61M3/0204; A61M3/0212; A61B5/03; A61B5/031; A61B5/1455; A61B5/14551; A61B5/14553; A61M2202/00; A61M2202/04; A61M2202/0464; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3653; A61M2210/00; A61M2210/06; A61M2210/0693
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
158 words
A method of diagnosing the condition of suspected hypoxic-ischemic central nervous system tissue of a mammal, comprising: (a) providing a synthetic spinal fluid comprising at least one oxygenated oxygen-carrying component and essential electrolytes to compatibilize the oxygen-carrying component for use with central nervous system tissue; (b) injecting said synthetic spinal fluid into at least a first portion of the cerebrospinal pathway of said mammal to contact said tissue to become a diagnostic fluid; (c) withdrawing said diagnostic fluid from a second portion of said pathway to create a circulation of said fluid through at least a portion of said pathway; (d) monitoring the composition of said diagnostic fluid; and (e) comparing constituents of said fluid for at least a selected difference in the compositions of said synthetic spinal and diagnostic fluids; whereby said selected differences in said compositions are at least diagnostic of the condition of said suspected hypoxic-ischemic tissue disposed along said portion of said cerebrospinal pathway.
Claim 2
Independent Claim
158 words
A method of diagnosing the condition of suspected hypoxic-ischemic central nervous system tissue of a mammal, comprising: (a) providing a synthetic spinal fluid comprising at least one oxygenated oxygen-carrying component and essential electrolytes to compatibilize the oxygen-carrying component for use with central nervous system tissue; (b) injecting said synthetic spinal fluid into at least a first portion of the cerebrospinal pathway of said mammal to contact said tissue to become a diagnostic fluid; (c) withdrawing said diagnostic fluid from a second portion of said pathway to create a circulation of said fluid through at least a portion of said pathway; (d) monitoring the composition of said diagnostic fluid; and (e) comparing constituents of said fluid for at least a selected difference in the compositions of said synthetic spinal and diagnostic fluids; whereby said selected differences in said compositions are at least diagnostic of the condition of said suspected hypoxic-ischemic tissue disposed along said portion of said cerebrospinal pathway.
Claim 3
Dependent Claim
15 words
The invention of claim 1 wherein said selected difference is a difference in oxygen content.
Claim 4
Dependent Claim
16 words
The invention of claim 1 wherein said selected difference is a difference in lactic acid concentration.
Claim 5
Dependent Claim
16 words
The invention of claim 1 wherein said selected difference is a difference in carbon dioxide concentration.
Claim 6
Dependent Claim
15 words
The invention of claim 1 wherein said selected difference is a difference in ammonia concentration.
Claim 7
Dependent Claim
15 words
The invention of claim 1 wherein said selected difference is a difference in enzyme content.
Claim 8
Dependent Claim
13 words
The invention of claim 1 wherein said difference is a difference in pH.
Claim 9
Dependent Claim
13 words
The invention of claim 1 wherein said difference is a difference in GABA.
Claim 10
Dependent Claim
14 words
The invention of claim 1 wherein said difference is a difference in microorganism content.
Claim 11
Dependent Claim
13 words
The invention of claim 9 wherein said microorganism content is a bacterial content.
Claim 12
Dependent Claim
14 words
The invention of claim 1 wherein said difference is a difference in ion concentration.
Claim 13
Dependent Claim
16 words
The invention of claim 11 wherein said ion concentration difference is a sodium ion concentration difference.
Claim 14
Dependent Claim
17 words
The invention of claim 11 wherein said difference is the difference in the concentration of potassium ions.
Claim 15
Dependent Claim
15 words
The invention of claim 1 wherein said difference is a difference in amino acid concentration.
Claim 16
Dependent Claim
16 words
The invention of claim 1 wherein said difference is a difference in concentration of malignant cells.
Claim 17
Dependent Claim
16 words
The invention of claim 1 wherein said difference is a difference in concentration of myelin fragments.
Claim 18
Dependent Claim
15 words
The invention of claim 1 wherein said difference is a difference in identifiable cellular materials.
Claim 19
Dependent Claim
17 words
The invention of claim 1 wherein said difference is a difference in concentration of identifiable cellular organelles.
Claim 20
Dependent Claim
13 words
The invention of claim 1 wherein said difference is a difference in protein.
Claim 21
Dependent Claim
13 words
The invention of claim 1 wherein said difference is a difference in fats.
Claim 22
Dependent Claim
14 words
The invention of claim 1 wherein said difference is a difference in fat content.
Claim 23
Dependent Claim
14 words
The invention of claim 1 wherein said difference is a difference in RNA content.
Claim 24
Dependent Claim
14 words
The invention of claim 1 wherein said difference is a difference in DNA content.
Claim 25
Dependent Claim
15 words
The invention of claim 1 wherein said difference is a difference in cellular metabolic products.
Claim 26
Dependent Claim
14 words
The invention of claim 1 wherein said difference is a difference in metabolite content.
Claim 27
Dependent Claim
14 words
The invention of claim 1 wherein said difference is a difference in neurotransmitter content.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-29 | 1987-11-28 | 1988-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-29 | 1991-11-28 | 1992-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-29 | 1995-11-28 | 1996-05-29 | $7700.00 | Window Closed / Lapsed |