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US4448718A
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Method for the preparation of collagen-glycosaminoglycan composite materials
Assignee: Massachusetts Institute of Technology
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Filing: 1983-09-13
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Granted: 1984-05-15
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Expires: 2003-09-13
Abstract
Abstract A process for preparing a crosslinked collagen-glycosaminoglycan composite material which comprises forming an uncrosslinked composite material from collagen and a glycosaminoglycan and contacting the uncrosslinked composite with a gaseous aldehyde until a crosslinked product having an M c of from about 800 to about 60,000 is disclosed along with composite materials prepared by this process. Artificial skin produced by this process is more stable toward long-term storage than similar materials prepared using other methods of crosslinking.
Inventors
- 👤 Ioannis V. Yannas
- 👤 James F. Kirk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:25
CPC Classifications
C; C08; C08H; C08H1/00; C08H1/06; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L27/00; A61L27/14; A61L27/26; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/924
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
47 words
A process for preparing a crosslinked collagen-glycosaminoglycan composite material, which comprises: forming an uncrosslinked composite material from collagen and a glycosaminoglycan; and contacting said uncrosslinked composite with a gaseous aldehyde until a crosslinked product having an M c of from about 800 to about 60,000 is formed.
Claim 2
Dependent Claim
47 words
A process for preparing a crosslinked collagen-glycosaminoglycan composite material, which comprises: forming an uncrosslinked composite material from collagen and a glycosaminoglycan; and contacting said uncrosslinked composite with a gaseous aldehyde until a crosslinked product having an M c of from about 800 to about 60,000 is formed.
Claim 3
Dependent Claim
32 words
The process of claim 1, wherein said contacting is with air containing vapor from a liquid or solid aldehyde or from a solution of an aldehyde in water or an organic solvent.
Claim 4
Dependent Claim
31 words
The process of claim 1, wherein said contacting is with the vapor of an aldehyde selected from the group consisting of aliphatic mono- and dialdehydes containing up to 8 carbon atoms.
Claim 5
Dependent Claim
14 words
The process of claim 3, wherein said aldehyde is formaldehyde, acetaldehyde, glyoxal, or glutaraldehyde.
Claim 6
Dependent Claim
10 words
The process of claim 4, wherein said aldehyde is glutaraldehyde.
Claim 7
Dependent Claim
27 words
The process of claim 1, wherein said contacting takes place until a crosslinked product having an M c of from about 8,000 to about 25,000 is formed.
Claim 8
Dependent Claim
15 words
The process of claim 1, wherein said uncrosslinked composite material contains less than 1.0% water.
Claim 9
Dependent Claim
15 words
The process of claim 7, wherein said uncrosslinked composite material contains less than 0.2% water.
Claim 10
Dependent Claim
14 words
The process of claim 8, wherein said contacting is with air containing glutaraldehyde vapor.
Claim 11
Dependent Claim
12 words
A crosslinked collagen-glycosaminoglycan composite material prepared by the process of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-15 | 1987-11-14 | 1988-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-15 | 1991-11-14 | 1992-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-15 | 1995-11-14 | 1996-05-15 | $7700.00 | Window Closed / Lapsed |