Patent US4444787A successfully refreshed from Google Patents.
US4444787A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ophthalmic topical use of collagen cross-linking inhibitors
Assignee: The University of Texas System
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Filing: 1981-07-06
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Granted: 1984-04-24
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Expires: 2001-07-06
Abstract
Abstract This invention relates to the treatment of wounded ocular tissue by the topical application of collagen cross-linking inhibitors to the tissue in order to reduce the cross-linking of collagen fibrils in the wounded tissue.
Inventors
- 👤 Louise C. Moorhead
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/275
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
42 words
A method for treating wounded mammalian ocular tissue to reduce the cross-linking of collagen fibrils in said tissue, comprising: the topical application of a pharmacologically suitable composition comprising an admixture of a therapeutically effective amount of BAPN with a suitable topical vehicle.
Claim 2
Independent Claim
42 words
A method for treating wounded mammalian ocular tissue to reduce the cross-linking of collagen fibrils in said tissue, comprising: the topical application of a pharmacologically suitable composition comprising an admixture of a therapeutically effective amount of BAPN with a suitable topical vehicle.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein the concentration of BAPN ranges from about 25 to about 50 percent by weight of said composition.
Claim 4
Dependent Claim
18 words
The method of claim 2 wherein said composition comprises BAPN admixed with a physiologically stable buffered saline solution.
Claim 5
Dependent Claim
17 words
The method of claim 1 wherein said pharmacologically suitable composition comprises BAPN admixed with a suitable ointment.
Claim 6
Dependent Claim
32 words
The method of claim 1 wherein said pharmacologically suitable composition comprises BAPN admixed with a suitable ointment and the concentration by weight of BAPN is not greater than 50% of said composition.
References Cited (Backward Citations)
US2742491A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-24 | 1987-10-24 | 1988-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-24 | 1991-10-24 | 1992-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-24 | 1995-10-24 | 1996-04-24 | $7700.00 | Window Closed / Lapsed |